Antinociceptive local activity of 4-allyl-1-hydroxy2-methoxybenzene (eugenol) by the formalin test: an anti-inflammatory effect

• Autor(a) principal: Lugo-Lugo, Daniela Elizabeth
• Data de Publicação: 2019
• Outros Autores: Pozos-Guillén, Amaury de Jesús, Zapata-Morales, Juan Ramón, Rodríguez-Chong, Antonio, Rangel-López, Azahel de Jesús, Saavedra-Leos, María Zenaida, Vértiz-Hernández, Angel Antonio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Pharmaceutical Sciences
• Texto Completo: https://www.revistas.usp.br/bjps/article/view/164741
• topic: Eugenol/analgesic/anti-inflammatory effect; Diclofenac effect; Antinociception; Formalin test; Pain

Eugenol has been employed for decades as a condiment, an antimycotic, an antibacterial, an antiviral, and an antioxidant, and it is one of the natural analgesics most frequently utilized for pain and inflammation. Our objective was to determine the analgesic/anti-inflammatory effect of eugenol compared with diclofenac, naproxen, and tramadol using the formalin test. The formalin method was used in 6- to 10-week-old Wistar rats (weighing 250 g each) divided into six groups: saline (0.9%); formalin (5%); diclofenac (250 µg/kg); naproxen (400 µg/kg); tramadol (500 µg/kg), and eugenol (1,400 µg/kg), in the intraplantar part of the hind-end trunk of the rats, with n = 5 per group. Eugenol diminished 44.4% of nociceptive behavior in phase 1 and 48% in phase 2 (p ≤0.05 vs formalin). Eugenol was shown to be 1.14 times more effective than diclofenac, but 1.62 and 1.75 times less effective than naproxen and tramadol, respectively, in phase 1 and 1.45 times less effective than diclofenac and naproxen and 1.66 less effective than tramadol in phase 2 (p ≤0.05). These data suggest that eugenol possesses moderate activity in the acute pain phase and greater activity in inflammatory-type pain, and both effects are comparable to those produced by diclofenac and are less than the effects produced by naproxen and tramadol in the formalin test.