PAK6: a potential anti-cancer target

Detalhes bibliográficos
Autor(a) principal: Gong, Chan-Chan
Data de Publicação: 2020
Outros Autores: Li, Tong-Tong, Pei, Dong-Sheng
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/182720
Resumo: p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interacting partner of the androgen receptor (AR), is associated with an array of cellular processes implicated in tumor progression. However, the full biological implications of PAK6 activity during cancer remain poorly understood. In this review, we assess our current understanding of the physiological roles of classical PAK6 functionality in mammals, in addition to its emerging role in tumorigenesis.
id USP-31_963dbdb4ef3f6fd0a18015064988f4de
oai_identifier_str oai:revistas.usp.br:article/182720
network_acronym_str USP-31
network_name_str Brazilian Journal of Pharmaceutical Sciences
repository_id_str
spelling PAK6: a potential anti-cancer targetPAK6androgen Receptor (AR)cancer therapymiRNAsp21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interacting partner of the androgen receptor (AR), is associated with an array of cellular processes implicated in tumor progression. However, the full biological implications of PAK6 activity during cancer remain poorly understood. In this review, we assess our current understanding of the physiological roles of classical PAK6 functionality in mammals, in addition to its emerging role in tumorigenesis.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18272010.1590/s2175-97902019000318315Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18315Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18315Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e183152175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/182720/169583Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGong, Chan-Chan Li, Tong-Tong Pei, Dong-Sheng 2021-06-12T19:46:54Zoai:revistas.usp.br:article/182720Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv PAK6: a potential anti-cancer target
title PAK6: a potential anti-cancer target
spellingShingle PAK6: a potential anti-cancer target
Gong, Chan-Chan
PAK6
androgen Receptor (AR)
cancer therapy
miRNAs
title_short PAK6: a potential anti-cancer target
title_full PAK6: a potential anti-cancer target
title_fullStr PAK6: a potential anti-cancer target
title_full_unstemmed PAK6: a potential anti-cancer target
title_sort PAK6: a potential anti-cancer target
author Gong, Chan-Chan
author_facet Gong, Chan-Chan
Li, Tong-Tong
Pei, Dong-Sheng
author_role author
author2 Li, Tong-Tong
Pei, Dong-Sheng
author2_role author
author
dc.contributor.author.fl_str_mv Gong, Chan-Chan
Li, Tong-Tong
Pei, Dong-Sheng
dc.subject.por.fl_str_mv PAK6
androgen Receptor (AR)
cancer therapy
miRNAs
topic PAK6
androgen Receptor (AR)
cancer therapy
miRNAs
description p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interacting partner of the androgen receptor (AR), is associated with an array of cellular processes implicated in tumor progression. However, the full biological implications of PAK6 activity during cancer remain poorly understood. In this review, we assess our current understanding of the physiological roles of classical PAK6 functionality in mammals, in addition to its emerging role in tumorigenesis.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/182720
10.1590/s2175-97902019000318315
url https://www.revistas.usp.br/bjps/article/view/182720
identifier_str_mv 10.1590/s2175-97902019000318315
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/182720/169583
dc.rights.driver.fl_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18315
Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18315
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18315
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
_version_ 1800222915572006912

Registros relacionados