Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives

Detalhes bibliográficos
Autor(a) principal: Jin, Qing-Hao
Data de Publicação: 2020
Outros Autores: Fu, Zhi-Yang, Xia, Ya-Nan, Liu, Bing-Yu, Jiang, Hai-Ying
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/181570
Resumo: In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 μM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 μM.
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spelling Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivativesFlavonoidsSynthesisIsoprenyloxyflavonesAntibacterial activityIn the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 μM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 μM.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18157010.1590/s2175-97901919000417721Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e17721 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e17721 Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e17721 2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181570/168562Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessJin, Qing-Hao Fu, Zhi-Yang Xia, Ya-Nan Liu, Bing-Yu Jiang, Hai-Ying 2021-06-12T19:46:54Zoai:revistas.usp.br:article/181570Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
title Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
spellingShingle Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
Jin, Qing-Hao
Flavonoids
Synthesis
Isoprenyloxyflavones
Antibacterial activity
title_short Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
title_full Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
title_fullStr Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
title_full_unstemmed Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
title_sort Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
author Jin, Qing-Hao
author_facet Jin, Qing-Hao
Fu, Zhi-Yang
Xia, Ya-Nan
Liu, Bing-Yu
Jiang, Hai-Ying
author_role author
author2 Fu, Zhi-Yang
Xia, Ya-Nan
Liu, Bing-Yu
Jiang, Hai-Ying
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Jin, Qing-Hao
Fu, Zhi-Yang
Xia, Ya-Nan
Liu, Bing-Yu
Jiang, Hai-Ying
dc.subject.por.fl_str_mv Flavonoids
Synthesis
Isoprenyloxyflavones
Antibacterial activity
topic Flavonoids
Synthesis
Isoprenyloxyflavones
Antibacterial activity
description In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 μM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 μM.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/181570
10.1590/s2175-97901919000417721
url https://www.revistas.usp.br/bjps/article/view/181570
identifier_str_mv 10.1590/s2175-97901919000417721
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/181570/168562
dc.rights.driver.fl_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e17721
Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e17721
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e17721
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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