Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice

Detalhes bibliográficos
Autor(a) principal: Guo, Ying
Data de Publicação: 2022
Outros Autores: Dai, Rongji, Deng, Yulin, Sun, Lili, Meng, Shiying, Xin, Nian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/205077
Resumo: The extract of Belamcanda chinensis leaves (BCLE) is a traditional Chinese herbal medicine for the treatment of diabetes-related hyperlipidemia in Hainan province, South China. In this study, the lipid-decreasing effects of BCLE on obese diabetes were investigated on KK-Ay mice. The component F2 ameliorated lipid disorder, as indicated by decreased levels of body weight, liver index, levels of TC, TG and LDL-c in the serum and liver. The enhancement effect of F2 on liver SOD and the inhibitory effect of F2 on MDA demonstrated that F2 exhibited significant antioxidant activity on liver injury. F2 also prevented vacuolar degeneration and reduced pathological tissue injury in liver. In addition, the component F1 decreased the levels of TG, LDL-c and MDA in the liver. These findings suggest that F2 may have therapeutic potential in the prevention and therapy of hyperlipemia and liver disease associated with obesity-related diabetes.
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spelling Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay miceBelamcanda chinensis leavesType 2 diabetesHypolipidemic effectSODMDAThe extract of Belamcanda chinensis leaves (BCLE) is a traditional Chinese herbal medicine for the treatment of diabetes-related hyperlipidemia in Hainan province, South China. In this study, the lipid-decreasing effects of BCLE on obese diabetes were investigated on KK-Ay mice. The component F2 ameliorated lipid disorder, as indicated by decreased levels of body weight, liver index, levels of TC, TG and LDL-c in the serum and liver. The enhancement effect of F2 on liver SOD and the inhibitory effect of F2 on MDA demonstrated that F2 exhibited significant antioxidant activity on liver injury. F2 also prevented vacuolar degeneration and reduced pathological tissue injury in liver. In addition, the component F1 decreased the levels of TG, LDL-c and MDA in the liver. These findings suggest that F2 may have therapeutic potential in the prevention and therapy of hyperlipemia and liver disease associated with obesity-related diabetes.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20507710.1590/s2175-97902020000118957 Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/205077/194483https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGuo, Ying Dai, RongjiDeng, YulinSun, LiliMeng, ShiyingXin, Nian2023-05-25T14:26:44Zoai:revistas.usp.br:article/205077Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-25T14:26:44Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice
title Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice
spellingShingle Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice
Guo, Ying
Belamcanda chinensis leaves
Type 2 diabetes
Hypolipidemic effect
SOD
MDA
title_short Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice
title_full Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice
title_fullStr Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice
title_full_unstemmed Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice
title_sort Hypolipidemic properties of the extracts of Belamcanda chinensis leaves (BCLE) in KK-Ay mice
author Guo, Ying
author_facet Guo, Ying
Dai, Rongji
Deng, Yulin
Sun, Lili
Meng, Shiying
Xin, Nian
author_role author
author2 Dai, Rongji
Deng, Yulin
Sun, Lili
Meng, Shiying
Xin, Nian
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Guo, Ying
Dai, Rongji
Deng, Yulin
Sun, Lili
Meng, Shiying
Xin, Nian
dc.subject.por.fl_str_mv Belamcanda chinensis leaves
Type 2 diabetes
Hypolipidemic effect
SOD
MDA
topic Belamcanda chinensis leaves
Type 2 diabetes
Hypolipidemic effect
SOD
MDA
description The extract of Belamcanda chinensis leaves (BCLE) is a traditional Chinese herbal medicine for the treatment of diabetes-related hyperlipidemia in Hainan province, South China. In this study, the lipid-decreasing effects of BCLE on obese diabetes were investigated on KK-Ay mice. The component F2 ameliorated lipid disorder, as indicated by decreased levels of body weight, liver index, levels of TC, TG and LDL-c in the serum and liver. The enhancement effect of F2 on liver SOD and the inhibitory effect of F2 on MDA demonstrated that F2 exhibited significant antioxidant activity on liver injury. F2 also prevented vacuolar degeneration and reduced pathological tissue injury in liver. In addition, the component F1 decreased the levels of TG, LDL-c and MDA in the liver. These findings suggest that F2 may have therapeutic potential in the prevention and therapy of hyperlipemia and liver disease associated with obesity-related diabetes.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/205077
10.1590/s2175-97902020000118957
url https://www.revistas.usp.br/bjps/article/view/205077
identifier_str_mv 10.1590/s2175-97902020000118957
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/205077/194483
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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