Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/181103 |
Resumo: | The high exposure to acrylamide (AA) due to smoking and increased consumption of processed and fast foods in recent years, has become one of the health threatening problems. This study examined the effect of lemon juice on inflammation and adipokines in acrylamide-induced oxidative stress in rats. Forty animals were divided into five groups. Toxicity was induced by AA (35mg/kg) for two weeks in all groups except normal control group. After that, lemon juice in three doses was administrated to treatment groups for 4 weeks. Serum levels of adipokines and inflammatory parameters and both serum and liver levels of oxidative stress parameters were measured. The results showed groups were received AA had significant higher levels of malondialdehyde, tumor necrosis factor alpha, leptin and C-reactive protein and lower levels of total antioxidant capacity compared to the negative control group. Lemon juice in all three doses significantly improved serum levels of TAC, MDA, TNFα and hs-CRP in treated groups. Also, 7.5 ml/kg lemon juice significantly decreased leptin levels. However, lemon juice had no significant effect on adiponectin levels. This study suggests lemon juice as a potential dietary alternative could attenuate leptin levels and manage oxidative and inflammatory damages in acrylamide- induced toxicity in rats. |
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Brazilian Journal of Pharmaceutical Sciences |
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Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in ratsCitrus lemonAcrylamideInflammationLeptinAdiponectinThe high exposure to acrylamide (AA) due to smoking and increased consumption of processed and fast foods in recent years, has become one of the health threatening problems. This study examined the effect of lemon juice on inflammation and adipokines in acrylamide-induced oxidative stress in rats. Forty animals were divided into five groups. Toxicity was induced by AA (35mg/kg) for two weeks in all groups except normal control group. After that, lemon juice in three doses was administrated to treatment groups for 4 weeks. Serum levels of adipokines and inflammatory parameters and both serum and liver levels of oxidative stress parameters were measured. The results showed groups were received AA had significant higher levels of malondialdehyde, tumor necrosis factor alpha, leptin and C-reactive protein and lower levels of total antioxidant capacity compared to the negative control group. Lemon juice in all three doses significantly improved serum levels of TAC, MDA, TNFα and hs-CRP in treated groups. Also, 7.5 ml/kg lemon juice significantly decreased leptin levels. However, lemon juice had no significant effect on adiponectin levels. This study suggests lemon juice as a potential dietary alternative could attenuate leptin levels and manage oxidative and inflammatory damages in acrylamide- induced toxicity in rats.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18110310.1590/s2175-97902019000218285Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18285Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18285Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e182852175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181103/168041Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessHaidari, Fatemeh Mohammadshahi, Majid Zarei, Mehdi Fathi, Mojdeh 2021-01-19T16:47:30Zoai:revistas.usp.br:article/181103Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-19T16:47:30Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats |
title |
Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats |
spellingShingle |
Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats Haidari, Fatemeh Citrus lemon Acrylamide Inflammation Leptin Adiponectin |
title_short |
Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats |
title_full |
Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats |
title_fullStr |
Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats |
title_full_unstemmed |
Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats |
title_sort |
Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats |
author |
Haidari, Fatemeh |
author_facet |
Haidari, Fatemeh Mohammadshahi, Majid Zarei, Mehdi Fathi, Mojdeh |
author_role |
author |
author2 |
Mohammadshahi, Majid Zarei, Mehdi Fathi, Mojdeh |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Haidari, Fatemeh Mohammadshahi, Majid Zarei, Mehdi Fathi, Mojdeh |
dc.subject.por.fl_str_mv |
Citrus lemon Acrylamide Inflammation Leptin Adiponectin |
topic |
Citrus lemon Acrylamide Inflammation Leptin Adiponectin |
description |
The high exposure to acrylamide (AA) due to smoking and increased consumption of processed and fast foods in recent years, has become one of the health threatening problems. This study examined the effect of lemon juice on inflammation and adipokines in acrylamide-induced oxidative stress in rats. Forty animals were divided into five groups. Toxicity was induced by AA (35mg/kg) for two weeks in all groups except normal control group. After that, lemon juice in three doses was administrated to treatment groups for 4 weeks. Serum levels of adipokines and inflammatory parameters and both serum and liver levels of oxidative stress parameters were measured. The results showed groups were received AA had significant higher levels of malondialdehyde, tumor necrosis factor alpha, leptin and C-reactive protein and lower levels of total antioxidant capacity compared to the negative control group. Lemon juice in all three doses significantly improved serum levels of TAC, MDA, TNFα and hs-CRP in treated groups. Also, 7.5 ml/kg lemon juice significantly decreased leptin levels. However, lemon juice had no significant effect on adiponectin levels. This study suggests lemon juice as a potential dietary alternative could attenuate leptin levels and manage oxidative and inflammatory damages in acrylamide- induced toxicity in rats. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181103 10.1590/s2175-97902019000218285 |
url |
https://www.revistas.usp.br/bjps/article/view/181103 |
identifier_str_mv |
10.1590/s2175-97902019000218285 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181103/168041 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18285 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18285 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18285 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222915019407360 |