Radiolabeling of cidofovir with technetium-99m and biodistribution studies

Detalhes bibliográficos
Autor(a) principal: Arribada, Raquel Gregorio
Data de Publicação: 2020
Outros Autores: Pereira, Nara Caroline, Cardoso, Valbert Nascimento, Cunha Júnior, Armando da Silva, Barros, André Luís Branco de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/181834
Resumo: Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug.
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spelling Radiolabeling of cidofovir with technetium-99m and biodistribution studiesCidofovirRadiotracerTechnetium-99mBiodistributionScintigraphic imagingRadiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18183410.1590/s2175-97902019000418511Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18511 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18511 Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18511 2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181834/168735Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessArribada, Raquel Gregorio Pereira, Nara Caroline Cardoso, Valbert Nascimento Cunha Júnior, Armando da Silva Barros, André Luís Branco de 2021-06-12T19:46:54Zoai:revistas.usp.br:article/181834Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Radiolabeling of cidofovir with technetium-99m and biodistribution studies
title Radiolabeling of cidofovir with technetium-99m and biodistribution studies
spellingShingle Radiolabeling of cidofovir with technetium-99m and biodistribution studies
Arribada, Raquel Gregorio
Cidofovir
Radiotracer
Technetium-99m
Biodistribution
Scintigraphic imaging
title_short Radiolabeling of cidofovir with technetium-99m and biodistribution studies
title_full Radiolabeling of cidofovir with technetium-99m and biodistribution studies
title_fullStr Radiolabeling of cidofovir with technetium-99m and biodistribution studies
title_full_unstemmed Radiolabeling of cidofovir with technetium-99m and biodistribution studies
title_sort Radiolabeling of cidofovir with technetium-99m and biodistribution studies
author Arribada, Raquel Gregorio
author_facet Arribada, Raquel Gregorio
Pereira, Nara Caroline
Cardoso, Valbert Nascimento
Cunha Júnior, Armando da Silva
Barros, André Luís Branco de
author_role author
author2 Pereira, Nara Caroline
Cardoso, Valbert Nascimento
Cunha Júnior, Armando da Silva
Barros, André Luís Branco de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Arribada, Raquel Gregorio
Pereira, Nara Caroline
Cardoso, Valbert Nascimento
Cunha Júnior, Armando da Silva
Barros, André Luís Branco de
dc.subject.por.fl_str_mv Cidofovir
Radiotracer
Technetium-99m
Biodistribution
Scintigraphic imaging
topic Cidofovir
Radiotracer
Technetium-99m
Biodistribution
Scintigraphic imaging
description Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/181834
10.1590/s2175-97902019000418511
url https://www.revistas.usp.br/bjps/article/view/181834
identifier_str_mv 10.1590/s2175-97902019000418511
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/181834/168735
dc.rights.driver.fl_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18511
Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18511
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18511
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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