Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/181515 |
Resumo: | Radiotherapy is often used for the treatment of cancer. However, it causes some side effects in patients. This study aimed to determine the hepatoprotective effects of Urtica dioica L. seed-extract (UDSE) in radiation-induced liver injury. Thirty-two male rats were randomly divided into 4 groups (n=8): control(C) group: no action was taken; radiation (R) group: irradiation was administrated at 5Gy singlefraction, radiation with UDSE(R+UDSE) group: irradiation was administrated at 5 Gy single-fraction and animals were fed pellets with 30 mL UDSE/kg; UDSE group: animals were fed pellets with 30 mL UDSE/kg. All of the experiments were performed in all of the groups over 10 days. Malondialdehyde (MDA) and reduced-glutathione (GSH) levels and superoxide-dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), aspartate-transaminase (AST), and alanine-aminotransferase (ALT) activities were determined. Histopathological findings were also evaluated in liver tissues. SOD, CAT and GSH-Px activities and GSH levels in the serum and liver were significantly increased, while MDA levels decreased in the R+UDSE group compared with the R group (P<0.05). Moreover, AST and ALT serum activities in the R+UDSE group were lower than those in the R group (P<0.05). In addition, radiation induced degenerative/necrotic changes in the R group were significantly compensated in the R+UDSE group. The results showed that radiation increased oxidative stress and decreased antioxidant capacity, as well as degeneration in the liver. However, UDSE attenuated these degenerative changes. |
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oai:revistas.usp.br:article/181515 |
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Brazilian Journal of Pharmaceutical Sciences |
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Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated ratsRadiationUrtica dioica Lseed extractOxidative stressAntioxidantTissue injuryRadiotherapy is often used for the treatment of cancer. However, it causes some side effects in patients. This study aimed to determine the hepatoprotective effects of Urtica dioica L. seed-extract (UDSE) in radiation-induced liver injury. Thirty-two male rats were randomly divided into 4 groups (n=8): control(C) group: no action was taken; radiation (R) group: irradiation was administrated at 5Gy singlefraction, radiation with UDSE(R+UDSE) group: irradiation was administrated at 5 Gy single-fraction and animals were fed pellets with 30 mL UDSE/kg; UDSE group: animals were fed pellets with 30 mL UDSE/kg. All of the experiments were performed in all of the groups over 10 days. Malondialdehyde (MDA) and reduced-glutathione (GSH) levels and superoxide-dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), aspartate-transaminase (AST), and alanine-aminotransferase (ALT) activities were determined. Histopathological findings were also evaluated in liver tissues. SOD, CAT and GSH-Px activities and GSH levels in the serum and liver were significantly increased, while MDA levels decreased in the R+UDSE group compared with the R group (P<0.05). Moreover, AST and ALT serum activities in the R+UDSE group were lower than those in the R group (P<0.05). In addition, radiation induced degenerative/necrotic changes in the R group were significantly compensated in the R+UDSE group. The results showed that radiation increased oxidative stress and decreased antioxidant capacity, as well as degeneration in the liver. However, UDSE attenuated these degenerative changes.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2021-03-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18151510.1590/s2175-97902019000318354Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18354Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18354Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e183542175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181515/168537Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessYıldızhan, Kenan Demirtaş, Ömer Can Uyar, Ahmet Huyut, Zübeyir Çakir, Tahir Keleş, Ömer Faruk Yener, Zabit 2021-06-12T19:46:54Zoai:revistas.usp.br:article/181515Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats |
title |
Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats |
spellingShingle |
Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats Yıldızhan, Kenan Radiation Urtica dioica L seed extract Oxidative stress Antioxidant Tissue injury |
title_short |
Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats |
title_full |
Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats |
title_fullStr |
Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats |
title_full_unstemmed |
Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats |
title_sort |
Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats |
author |
Yıldızhan, Kenan |
author_facet |
Yıldızhan, Kenan Demirtaş, Ömer Can Uyar, Ahmet Huyut, Zübeyir Çakir, Tahir Keleş, Ömer Faruk Yener, Zabit |
author_role |
author |
author2 |
Demirtaş, Ömer Can Uyar, Ahmet Huyut, Zübeyir Çakir, Tahir Keleş, Ömer Faruk Yener, Zabit |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Yıldızhan, Kenan Demirtaş, Ömer Can Uyar, Ahmet Huyut, Zübeyir Çakir, Tahir Keleş, Ömer Faruk Yener, Zabit |
dc.subject.por.fl_str_mv |
Radiation Urtica dioica L seed extract Oxidative stress Antioxidant Tissue injury |
topic |
Radiation Urtica dioica L seed extract Oxidative stress Antioxidant Tissue injury |
description |
Radiotherapy is often used for the treatment of cancer. However, it causes some side effects in patients. This study aimed to determine the hepatoprotective effects of Urtica dioica L. seed-extract (UDSE) in radiation-induced liver injury. Thirty-two male rats were randomly divided into 4 groups (n=8): control(C) group: no action was taken; radiation (R) group: irradiation was administrated at 5Gy singlefraction, radiation with UDSE(R+UDSE) group: irradiation was administrated at 5 Gy single-fraction and animals were fed pellets with 30 mL UDSE/kg; UDSE group: animals were fed pellets with 30 mL UDSE/kg. All of the experiments were performed in all of the groups over 10 days. Malondialdehyde (MDA) and reduced-glutathione (GSH) levels and superoxide-dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), aspartate-transaminase (AST), and alanine-aminotransferase (ALT) activities were determined. Histopathological findings were also evaluated in liver tissues. SOD, CAT and GSH-Px activities and GSH levels in the serum and liver were significantly increased, while MDA levels decreased in the R+UDSE group compared with the R group (P<0.05). Moreover, AST and ALT serum activities in the R+UDSE group were lower than those in the R group (P<0.05). In addition, radiation induced degenerative/necrotic changes in the R group were significantly compensated in the R+UDSE group. The results showed that radiation increased oxidative stress and decreased antioxidant capacity, as well as degeneration in the liver. However, UDSE attenuated these degenerative changes. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181515 10.1590/s2175-97902019000318354 |
url |
https://www.revistas.usp.br/bjps/article/view/181515 |
identifier_str_mv |
10.1590/s2175-97902019000318354 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181515/168537 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18354 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18354 Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18354 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222915090710528 |