Resveratrol inhibits nicotine-induced conditioned place preference in mice
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/210597 |
Resumo: | Nicotine addiction leads to in a huge burden on public health and the economy worldwide. Resveratrol (3,5,4’-tetrahydroxystilbene) is the most well-known polyphenolic stilbenoid. Resveratrol was shown to exhibit positive effects on numerous mechanisms that are important for drug and substance addiction. Thus, this study aimed to examine the effect of resveratrol on nicotine addiction. Intraperitoneal (i.p.) treatment with nicotine (0.5 mg/kg) significantly enhanced time spent in the nicotine-paired compartment. Resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) co-administered with nicotine during the 3-day conditioning period effectively diminished the acquisition of nicotine-induced conditioned place preference (CPP). On the other hand, the administration of resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) decreased the low dose (0.1 mg/kg, i.p.) nicotine-induced reinstatement. The results suggest that resveratrol and varenicline inhibit the acquisition and reinstatement of nicotine’s reward properties. Resveratrol displayed similar results in the CPP phases as obtained with the reference drug varenicline. In conclusion, resveratrol could be beneficial as an adjuvant pharmacotherapy for nicotine addiction; however, more investigation is needed to completely explain this property. |
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Resveratrol inhibits nicotine-induced conditioned place preference in miceNicotine; Resveratrol; Acquisition; Reinstatement; Conditioned place preferenceNicotine addiction leads to in a huge burden on public health and the economy worldwide. Resveratrol (3,5,4’-tetrahydroxystilbene) is the most well-known polyphenolic stilbenoid. Resveratrol was shown to exhibit positive effects on numerous mechanisms that are important for drug and substance addiction. Thus, this study aimed to examine the effect of resveratrol on nicotine addiction. Intraperitoneal (i.p.) treatment with nicotine (0.5 mg/kg) significantly enhanced time spent in the nicotine-paired compartment. Resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) co-administered with nicotine during the 3-day conditioning period effectively diminished the acquisition of nicotine-induced conditioned place preference (CPP). On the other hand, the administration of resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) decreased the low dose (0.1 mg/kg, i.p.) nicotine-induced reinstatement. The results suggest that resveratrol and varenicline inhibit the acquisition and reinstatement of nicotine’s reward properties. Resveratrol displayed similar results in the CPP phases as obtained with the reference drug varenicline. In conclusion, resveratrol could be beneficial as an adjuvant pharmacotherapy for nicotine addiction; however, more investigation is needed to completely explain this property.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-04-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/21059710.1590/s2175-97902023e20883Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20883Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e20883Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e208832175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/210597/194610https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessYunusoğlu, Oruç2023-05-31T17:06:27Zoai:revistas.usp.br:article/210597Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-31T17:06:27Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Resveratrol inhibits nicotine-induced conditioned place preference in mice |
title |
Resveratrol inhibits nicotine-induced conditioned place preference in mice |
spellingShingle |
Resveratrol inhibits nicotine-induced conditioned place preference in mice Yunusoğlu, Oruç Nicotine; Resveratrol; Acquisition; Reinstatement; Conditioned place preference |
title_short |
Resveratrol inhibits nicotine-induced conditioned place preference in mice |
title_full |
Resveratrol inhibits nicotine-induced conditioned place preference in mice |
title_fullStr |
Resveratrol inhibits nicotine-induced conditioned place preference in mice |
title_full_unstemmed |
Resveratrol inhibits nicotine-induced conditioned place preference in mice |
title_sort |
Resveratrol inhibits nicotine-induced conditioned place preference in mice |
author |
Yunusoğlu, Oruç |
author_facet |
Yunusoğlu, Oruç |
author_role |
author |
dc.contributor.author.fl_str_mv |
Yunusoğlu, Oruç |
dc.subject.por.fl_str_mv |
Nicotine; Resveratrol; Acquisition; Reinstatement; Conditioned place preference |
topic |
Nicotine; Resveratrol; Acquisition; Reinstatement; Conditioned place preference |
description |
Nicotine addiction leads to in a huge burden on public health and the economy worldwide. Resveratrol (3,5,4’-tetrahydroxystilbene) is the most well-known polyphenolic stilbenoid. Resveratrol was shown to exhibit positive effects on numerous mechanisms that are important for drug and substance addiction. Thus, this study aimed to examine the effect of resveratrol on nicotine addiction. Intraperitoneal (i.p.) treatment with nicotine (0.5 mg/kg) significantly enhanced time spent in the nicotine-paired compartment. Resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) co-administered with nicotine during the 3-day conditioning period effectively diminished the acquisition of nicotine-induced conditioned place preference (CPP). On the other hand, the administration of resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) decreased the low dose (0.1 mg/kg, i.p.) nicotine-induced reinstatement. The results suggest that resveratrol and varenicline inhibit the acquisition and reinstatement of nicotine’s reward properties. Resveratrol displayed similar results in the CPP phases as obtained with the reference drug varenicline. In conclusion, resveratrol could be beneficial as an adjuvant pharmacotherapy for nicotine addiction; however, more investigation is needed to completely explain this property. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/210597 10.1590/s2175-97902023e20883 |
url |
https://www.revistas.usp.br/bjps/article/view/210597 |
identifier_str_mv |
10.1590/s2175-97902023e20883 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/210597/194610 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20883 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e20883 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20883 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222917655527424 |