Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/153890 |
Resumo: | Caper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant are used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and antifungal. The aim of this study is to evaluate potential hypoglycemic effect of C. ovata var. palaestina extracts in alloxan-induced diabetic mice. For this purpose; diabetic mice were administered with 100, 300, 500 mg/kg (i.p.) doses of methanol extract of bud and fruit. Blood glucose levels were screened 60, 120, 240 and 360 min. after treatment. Furthermore, high resolution mass spectrometry (HRMS) analysis, ABTS and DPPH free radical scavenging activity test, and phenolic and flavonoid compounds analysis of extracts were carried out. The data obtained from in vivo study revealed that fruit-methanol 500 mg/kg (FM3), bud-methanol 300 mg/kg (BM2), bud-methanol 500 mg/kg (BM3) extracts showed significant hypoglycemic activity. All extracts indicated significant antioxidant activity, however bud-methanol (BM) extract demonstrated the most potent antioxidant activity. Moreover high levels of phenolic substances and flavonoids were involved in all extracts, but the highest levels were found in FM extract. HRMS study showed that rutin, quercetin 3-O-glucoside (isoquercitrin) and stachydrine substances had seen in BM extract. The results of this study showed that the C. ovata var. palaestina extracts which, indicate hypoglycemic, antioxidant activities, might provide additional support in diabetes. |
id |
USP-31_cb2912b688ea36a02c527ce695e78a04 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/153890 |
network_acronym_str |
USP-31 |
network_name_str |
Brazilian Journal of Pharmaceutical Sciences |
repository_id_str |
|
spelling |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extractC. ovata var. palaestina/extractC. ovata var. palaestina/hypoglycemic effect/antioxidant effectsDiabetes mellitusMiceCaper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant are used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and antifungal. The aim of this study is to evaluate potential hypoglycemic effect of C. ovata var. palaestina extracts in alloxan-induced diabetic mice. For this purpose; diabetic mice were administered with 100, 300, 500 mg/kg (i.p.) doses of methanol extract of bud and fruit. Blood glucose levels were screened 60, 120, 240 and 360 min. after treatment. Furthermore, high resolution mass spectrometry (HRMS) analysis, ABTS and DPPH free radical scavenging activity test, and phenolic and flavonoid compounds analysis of extracts were carried out. The data obtained from in vivo study revealed that fruit-methanol 500 mg/kg (FM3), bud-methanol 300 mg/kg (BM2), bud-methanol 500 mg/kg (BM3) extracts showed significant hypoglycemic activity. All extracts indicated significant antioxidant activity, however bud-methanol (BM) extract demonstrated the most potent antioxidant activity. Moreover high levels of phenolic substances and flavonoids were involved in all extracts, but the highest levels were found in FM extract. HRMS study showed that rutin, quercetin 3-O-glucoside (isoquercitrin) and stachydrine substances had seen in BM extract. The results of this study showed that the C. ovata var. palaestina extracts which, indicate hypoglycemic, antioxidant activities, might provide additional support in diabetes.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/15389010.1590/s2175-97902018000318031Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 3 (2018); e18031Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 3 (2018); e18031Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 3 (2018); e180312175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/153890/150227Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessOkur, Mehmet EvrenÖzbek, HanefiPolat, Derya ÇiçekYılmaz, SezenArslan, Rana2019-03-17T13:19:45Zoai:revistas.usp.br:article/153890Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-03-17T13:19:45Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract |
title |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract |
spellingShingle |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract Okur, Mehmet Evren C. ovata var. palaestina/extract C. ovata var. palaestina/hypoglycemic effect/antioxidant effects Diabetes mellitus Mice |
title_short |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract |
title_full |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract |
title_fullStr |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract |
title_full_unstemmed |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract |
title_sort |
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract |
author |
Okur, Mehmet Evren |
author_facet |
Okur, Mehmet Evren Özbek, Hanefi Polat, Derya Çiçek Yılmaz, Sezen Arslan, Rana |
author_role |
author |
author2 |
Özbek, Hanefi Polat, Derya Çiçek Yılmaz, Sezen Arslan, Rana |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Okur, Mehmet Evren Özbek, Hanefi Polat, Derya Çiçek Yılmaz, Sezen Arslan, Rana |
dc.subject.por.fl_str_mv |
C. ovata var. palaestina/extract C. ovata var. palaestina/hypoglycemic effect/antioxidant effects Diabetes mellitus Mice |
topic |
C. ovata var. palaestina/extract C. ovata var. palaestina/hypoglycemic effect/antioxidant effects Diabetes mellitus Mice |
description |
Caper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant are used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and antifungal. The aim of this study is to evaluate potential hypoglycemic effect of C. ovata var. palaestina extracts in alloxan-induced diabetic mice. For this purpose; diabetic mice were administered with 100, 300, 500 mg/kg (i.p.) doses of methanol extract of bud and fruit. Blood glucose levels were screened 60, 120, 240 and 360 min. after treatment. Furthermore, high resolution mass spectrometry (HRMS) analysis, ABTS and DPPH free radical scavenging activity test, and phenolic and flavonoid compounds analysis of extracts were carried out. The data obtained from in vivo study revealed that fruit-methanol 500 mg/kg (FM3), bud-methanol 300 mg/kg (BM2), bud-methanol 500 mg/kg (BM3) extracts showed significant hypoglycemic activity. All extracts indicated significant antioxidant activity, however bud-methanol (BM) extract demonstrated the most potent antioxidant activity. Moreover high levels of phenolic substances and flavonoids were involved in all extracts, but the highest levels were found in FM extract. HRMS study showed that rutin, quercetin 3-O-glucoside (isoquercitrin) and stachydrine substances had seen in BM extract. The results of this study showed that the C. ovata var. palaestina extracts which, indicate hypoglycemic, antioxidant activities, might provide additional support in diabetes. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/153890 10.1590/s2175-97902018000318031 |
url |
https://www.revistas.usp.br/bjps/article/view/153890 |
identifier_str_mv |
10.1590/s2175-97902018000318031 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/153890/150227 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 3 (2018); e18031 Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 3 (2018); e18031 Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 3 (2018); e18031 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222913825079296 |