Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/182452 |
Resumo: | Objectives. This study sought to compare the estimated glomerular filtration rate and the indication of dose adjustment of antimicrobials when using Cockcroft-Gault or Modification of Diet in Renal Disease. Methods. A cross-sectional study was performed with patients admitted to the intensive care unit of a Brazilian general hospital. The glomerular filtration rate was calculated for patients on all days using the Cockcroft-Gault and Modification of Diet in Renal Disease equations. The difference in estimated glomerular filtration and the dose adjustment indication of antimicrobials were assessed. Results. A total of 631 patients were included in this study. The median estimated glomerular filtration was significantly higher when estimated using Modification of Diet in Renal Disease (100.3 mL/ min/1.73 m²) than the estimation by Cockcroft-Gault (83.2 mL/min) [p<0.001]. Greater differences in estimations produced by the two formulae were observed in patients at extremes of weight and age, and a different dose adjustment was indicated for all antimicrobials assessed. Conclusions. These results demonstrate a significant difference in estimated glomerular filtration rate values when calculated using either Cockcroft-Gault or Modification of Diet in Renal Disease as well as in the indication of dose adjustment in an intensive care unit. |
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Brazilian Journal of Pharmaceutical Sciences |
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Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in BrazilIntensive Care UnitsGlomerular Filtration RateAnti-infective AgentsRenal InsufficiencyObjectives. This study sought to compare the estimated glomerular filtration rate and the indication of dose adjustment of antimicrobials when using Cockcroft-Gault or Modification of Diet in Renal Disease. Methods. A cross-sectional study was performed with patients admitted to the intensive care unit of a Brazilian general hospital. The glomerular filtration rate was calculated for patients on all days using the Cockcroft-Gault and Modification of Diet in Renal Disease equations. The difference in estimated glomerular filtration and the dose adjustment indication of antimicrobials were assessed. Results. A total of 631 patients were included in this study. The median estimated glomerular filtration was significantly higher when estimated using Modification of Diet in Renal Disease (100.3 mL/ min/1.73 m²) than the estimation by Cockcroft-Gault (83.2 mL/min) [p<0.001]. Greater differences in estimations produced by the two formulae were observed in patients at extremes of weight and age, and a different dose adjustment was indicated for all antimicrobials assessed. Conclusions. These results demonstrate a significant difference in estimated glomerular filtration rate values when calculated using either Cockcroft-Gault or Modification of Diet in Renal Disease as well as in the indication of dose adjustment in an intensive care unit.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18245210.1590/s2175-97902020000117837Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e17837Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e17837Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e178372175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/182452/169289Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCamargo, Marianne Silveira Oliveira, Márcio Galvão Mistro, Sostenes Rocha, Izabel Cristina Pereira Santos, Camila NetoCastro, Caroline Tianeze de Passos, Luiz Carlos Santana 2021-06-12T19:46:54Zoai:revistas.usp.br:article/182452Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil |
title |
Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil |
spellingShingle |
Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil Camargo, Marianne Silveira Intensive Care Units Glomerular Filtration Rate Anti-infective Agents Renal Insufficiency |
title_short |
Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil |
title_full |
Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil |
title_fullStr |
Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil |
title_full_unstemmed |
Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil |
title_sort |
Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil |
author |
Camargo, Marianne Silveira |
author_facet |
Camargo, Marianne Silveira Oliveira, Márcio Galvão Mistro, Sostenes Rocha, Izabel Cristina Pereira Santos, Camila Neto Castro, Caroline Tianeze de Passos, Luiz Carlos Santana |
author_role |
author |
author2 |
Oliveira, Márcio Galvão Mistro, Sostenes Rocha, Izabel Cristina Pereira Santos, Camila Neto Castro, Caroline Tianeze de Passos, Luiz Carlos Santana |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Camargo, Marianne Silveira Oliveira, Márcio Galvão Mistro, Sostenes Rocha, Izabel Cristina Pereira Santos, Camila Neto Castro, Caroline Tianeze de Passos, Luiz Carlos Santana |
dc.subject.por.fl_str_mv |
Intensive Care Units Glomerular Filtration Rate Anti-infective Agents Renal Insufficiency |
topic |
Intensive Care Units Glomerular Filtration Rate Anti-infective Agents Renal Insufficiency |
description |
Objectives. This study sought to compare the estimated glomerular filtration rate and the indication of dose adjustment of antimicrobials when using Cockcroft-Gault or Modification of Diet in Renal Disease. Methods. A cross-sectional study was performed with patients admitted to the intensive care unit of a Brazilian general hospital. The glomerular filtration rate was calculated for patients on all days using the Cockcroft-Gault and Modification of Diet in Renal Disease equations. The difference in estimated glomerular filtration and the dose adjustment indication of antimicrobials were assessed. Results. A total of 631 patients were included in this study. The median estimated glomerular filtration was significantly higher when estimated using Modification of Diet in Renal Disease (100.3 mL/ min/1.73 m²) than the estimation by Cockcroft-Gault (83.2 mL/min) [p<0.001]. Greater differences in estimations produced by the two formulae were observed in patients at extremes of weight and age, and a different dose adjustment was indicated for all antimicrobials assessed. Conclusions. These results demonstrate a significant difference in estimated glomerular filtration rate values when calculated using either Cockcroft-Gault or Modification of Diet in Renal Disease as well as in the indication of dose adjustment in an intensive care unit. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/182452 10.1590/s2175-97902020000117837 |
url |
https://www.revistas.usp.br/bjps/article/view/182452 |
identifier_str_mv |
10.1590/s2175-97902020000117837 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/182452/169289 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e17837 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e17837 Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e17837 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222915560472576 |