Cell phenotypes as activity biomarkers in patients with Systemic Lupus Erythematosus

• Autor(a) principal: Cristina de Mello Gomide Loures
• Data de Publicação: 2023
• Outros Autores: Tânia Mara Pinto Dabés Guimarães, Karine Silveste Ferreira, Marcos Vinicius Ferreira Silva, Luan Carlos Vieira Alves, Fernanda Freire Campos Nunes, Renato Vargas Consoli, Cláudia Lopes Santoro Neiva, Paulo Madureira de Pádua, Luara Isabela dos Santos, Josimar Dornelas Moreira, Vicente de Paulo Coelho Peixoto de Toledo, Maria das Graças Carvalho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Pharmaceutical Sciences
• Texto Completo: https://www.revistas.usp.br/bjps/article/view/211560
• topic: Systemic Lupus Erythematosus; Lupus nephritis; T cells; B cells; NK cells

The pathogenesis of systemic lupus erythematosus (SLE) is complex. Few studies in Brazilian population have addressed cell phenotypes associated with immunological responses and their associations with SLE activity. The aim of this study is to investigate cell phenotypes associated to SLE diagnosis, treatment and activity. Twenty-eight SLE female patients (17 inactive, 11 active) and 10 healthy women were included in this study. Markers of natural killer (Nk), T and B cells in peripheral blood were evaluated by flow cytometry. Nkt cells were decreased only in SLE active patients. Activated CD4+, regulatory T FoxP3+ and B cells were decreased in both active and inactive SLE patients, compared to control group. The data corroborate the disruption of immune regulatory response in SLE patients and suggest phenotipic changes as possible biomarkers of SLE activity.