Development and characterization of photoprotective formulations containing keratin particles
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/181064 |
Resumo: | This work deals with development and evaluation of MFQ protective formulation, which contains two organic filters, namely: octyl-p-methoxycinnamate (OMC) and benzophenone-3 (BP-3); a photostabilizing agent called ethylhexylmethoxycrylene (EHMCR) and keratin particles. The MFQ formulation was evaluated in order to measure its pH, spin-spin lattice relaxation time (T2H), occlusivity factor, formulation efficacy, photostability and skin permeation, as well as keratin particle properties. Keratin particle size increased when incorporated to formulation, however, it did not affect pH. The MFQ formulation was found to be photostable and photoprotective, as evidenced by sunlight photostability test, sun protection factor (SPF), UVA/UVB ratio and critical wavelength. Interaction between keratin particles and active substances (OMC, BP-3 and EHMCR) was evidenced by T2H measurements. Evidences suggest that keratin reduces the permeation of both UV filters employed along this study, therefore, it can be stated that keratin has a promising potential for use in sunscreen formulations. |
id |
USP-31_dd97c8dde3bc3b648b8cc836cbd98675 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/181064 |
network_acronym_str |
USP-31 |
network_name_str |
Brazilian Journal of Pharmaceutical Sciences |
repository_id_str |
|
spelling |
Development and characterization of photoprotective formulations containing keratin particlesSunscreenKeratinOctylmethoxycinnamateBenzophenone-3EthylhexylmethoxycryleneThis work deals with development and evaluation of MFQ protective formulation, which contains two organic filters, namely: octyl-p-methoxycinnamate (OMC) and benzophenone-3 (BP-3); a photostabilizing agent called ethylhexylmethoxycrylene (EHMCR) and keratin particles. The MFQ formulation was evaluated in order to measure its pH, spin-spin lattice relaxation time (T2H), occlusivity factor, formulation efficacy, photostability and skin permeation, as well as keratin particle properties. Keratin particle size increased when incorporated to formulation, however, it did not affect pH. The MFQ formulation was found to be photostable and photoprotective, as evidenced by sunlight photostability test, sun protection factor (SPF), UVA/UVB ratio and critical wavelength. Interaction between keratin particles and active substances (OMC, BP-3 and EHMCR) was evidenced by T2H measurements. Evidences suggest that keratin reduces the permeation of both UV filters employed along this study, therefore, it can be stated that keratin has a promising potential for use in sunscreen formulations.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18106410.1590/s2175-97902019000217649Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17649Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17649Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e176492175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181064/168014Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTeixeira, Jessica Freitas, Zaida Maria Farias de Monteiro, Mariana Sato de Souza Bustamante Vermelho, Alane Beatriz Ricci Junior, Eduardo Santos, Elisabete Pereira dos 2021-01-19T16:47:29Zoai:revistas.usp.br:article/181064Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-19T16:47:29Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Development and characterization of photoprotective formulations containing keratin particles |
title |
Development and characterization of photoprotective formulations containing keratin particles |
spellingShingle |
Development and characterization of photoprotective formulations containing keratin particles Teixeira, Jessica Sunscreen Keratin Octylmethoxycinnamate Benzophenone-3 Ethylhexylmethoxycrylene |
title_short |
Development and characterization of photoprotective formulations containing keratin particles |
title_full |
Development and characterization of photoprotective formulations containing keratin particles |
title_fullStr |
Development and characterization of photoprotective formulations containing keratin particles |
title_full_unstemmed |
Development and characterization of photoprotective formulations containing keratin particles |
title_sort |
Development and characterization of photoprotective formulations containing keratin particles |
author |
Teixeira, Jessica |
author_facet |
Teixeira, Jessica Freitas, Zaida Maria Farias de Monteiro, Mariana Sato de Souza Bustamante Vermelho, Alane Beatriz Ricci Junior, Eduardo Santos, Elisabete Pereira dos |
author_role |
author |
author2 |
Freitas, Zaida Maria Farias de Monteiro, Mariana Sato de Souza Bustamante Vermelho, Alane Beatriz Ricci Junior, Eduardo Santos, Elisabete Pereira dos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Jessica Freitas, Zaida Maria Farias de Monteiro, Mariana Sato de Souza Bustamante Vermelho, Alane Beatriz Ricci Junior, Eduardo Santos, Elisabete Pereira dos |
dc.subject.por.fl_str_mv |
Sunscreen Keratin Octylmethoxycinnamate Benzophenone-3 Ethylhexylmethoxycrylene |
topic |
Sunscreen Keratin Octylmethoxycinnamate Benzophenone-3 Ethylhexylmethoxycrylene |
description |
This work deals with development and evaluation of MFQ protective formulation, which contains two organic filters, namely: octyl-p-methoxycinnamate (OMC) and benzophenone-3 (BP-3); a photostabilizing agent called ethylhexylmethoxycrylene (EHMCR) and keratin particles. The MFQ formulation was evaluated in order to measure its pH, spin-spin lattice relaxation time (T2H), occlusivity factor, formulation efficacy, photostability and skin permeation, as well as keratin particle properties. Keratin particle size increased when incorporated to formulation, however, it did not affect pH. The MFQ formulation was found to be photostable and photoprotective, as evidenced by sunlight photostability test, sun protection factor (SPF), UVA/UVB ratio and critical wavelength. Interaction between keratin particles and active substances (OMC, BP-3 and EHMCR) was evidenced by T2H measurements. Evidences suggest that keratin reduces the permeation of both UV filters employed along this study, therefore, it can be stated that keratin has a promising potential for use in sunscreen formulations. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181064 10.1590/s2175-97902019000217649 |
url |
https://www.revistas.usp.br/bjps/article/view/181064 |
identifier_str_mv |
10.1590/s2175-97902019000217649 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181064/168014 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17649 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17649 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17649 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222915004727296 |