Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/164717 |
Resumo: | The essential oil of the leaves of Eugenia sulcata, in the Myrtaceae family, has a demonstrated antihypertensive effect, but its effects on heart muscle and its toxicity have not yet been elucidated. Little chemical or biological data are available for E. sulcata, whether emphasizing the beneficial effects or the pharmacological security of this species. This study aims to evaluate myocardial contractility and to analyze angiotensin converting enzyme (ACE) and myosin ATPase activities associated with use of this essential oil. In addition, we evaluated the immunotoxicity of E. sulcata essential oil. Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were treated daily for 30 days (10 mg/kg of oil) to evaluate the isometric force of the papillary muscle, ACE measured by fluorimetry, and myosin ATPase activities by inorganic phosphate. Lymphocyte cultures were used to evaluate cytotoxicity, DNA damage, and mutagenicity of the essential oil. The results demonstrate that the treatment did not change the cardiac contraction force and did not alter the functioning of the sarcoplasmic reticulum, extrusion of the membrane calcium, or modify the membrane calcium channels or β-adrenergic receptor activity. Tetanic contractions were potentiated in the SHR animals. Myosin ATPase activity was also increased in the SHR animals. Cardiac ACE activity was reduced in both animal strains, and the serum ACE was reduced only in the SHR animals. The essential oil did not cause cytotoxicity or mutagenicity and presented low DNA damage. Our results demonstrated that the essential oil does not change myocardial contractility and does not present relevant immunotoxicity. |
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oai:revistas.usp.br:article/164717 |
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Brazilian Journal of Pharmaceutical Sciences |
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Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicityMyrtaceae/adverse effectsAngiotensin-Converting Enzyme Inhibitors/immunologyThe essential oil of the leaves of Eugenia sulcata, in the Myrtaceae family, has a demonstrated antihypertensive effect, but its effects on heart muscle and its toxicity have not yet been elucidated. Little chemical or biological data are available for E. sulcata, whether emphasizing the beneficial effects or the pharmacological security of this species. This study aims to evaluate myocardial contractility and to analyze angiotensin converting enzyme (ACE) and myosin ATPase activities associated with use of this essential oil. In addition, we evaluated the immunotoxicity of E. sulcata essential oil. Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were treated daily for 30 days (10 mg/kg of oil) to evaluate the isometric force of the papillary muscle, ACE measured by fluorimetry, and myosin ATPase activities by inorganic phosphate. Lymphocyte cultures were used to evaluate cytotoxicity, DNA damage, and mutagenicity of the essential oil. The results demonstrate that the treatment did not change the cardiac contraction force and did not alter the functioning of the sarcoplasmic reticulum, extrusion of the membrane calcium, or modify the membrane calcium channels or β-adrenergic receptor activity. Tetanic contractions were potentiated in the SHR animals. Myosin ATPase activity was also increased in the SHR animals. Cardiac ACE activity was reduced in both animal strains, and the serum ACE was reduced only in the SHR animals. The essential oil did not cause cytotoxicity or mutagenicity and presented low DNA damage. Our results demonstrated that the essential oil does not change myocardial contractility and does not present relevant immunotoxicity.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-12-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/16471710.1590/s2175-97902019000117742Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17742Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17742Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e177422175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/164717/157928Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Karolina TorresSilva, Fabricio Ocampo da Luz eSchneider, Leandro AlvesSantos, Carlos Eduardo Rangel dosSilva, Sue Elle Berro daFernandes, Maquelen BlancoRocha, LeandroOliveira, Luís Flávio Souza deMachado, Michel MansurMoreira, Cleci Menezes2021-01-11T18:07:52Zoai:revistas.usp.br:article/164717Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-11T18:07:52Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity |
title |
Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity |
spellingShingle |
Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity Santos, Karolina Torres Myrtaceae/adverse effects Angiotensin-Converting Enzyme Inhibitors/immunology |
title_short |
Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity |
title_full |
Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity |
title_fullStr |
Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity |
title_full_unstemmed |
Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity |
title_sort |
Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity |
author |
Santos, Karolina Torres |
author_facet |
Santos, Karolina Torres Silva, Fabricio Ocampo da Luz e Schneider, Leandro Alves Santos, Carlos Eduardo Rangel dos Silva, Sue Elle Berro da Fernandes, Maquelen Blanco Rocha, Leandro Oliveira, Luís Flávio Souza de Machado, Michel Mansur Moreira, Cleci Menezes |
author_role |
author |
author2 |
Silva, Fabricio Ocampo da Luz e Schneider, Leandro Alves Santos, Carlos Eduardo Rangel dos Silva, Sue Elle Berro da Fernandes, Maquelen Blanco Rocha, Leandro Oliveira, Luís Flávio Souza de Machado, Michel Mansur Moreira, Cleci Menezes |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Karolina Torres Silva, Fabricio Ocampo da Luz e Schneider, Leandro Alves Santos, Carlos Eduardo Rangel dos Silva, Sue Elle Berro da Fernandes, Maquelen Blanco Rocha, Leandro Oliveira, Luís Flávio Souza de Machado, Michel Mansur Moreira, Cleci Menezes |
dc.subject.por.fl_str_mv |
Myrtaceae/adverse effects Angiotensin-Converting Enzyme Inhibitors/immunology |
topic |
Myrtaceae/adverse effects Angiotensin-Converting Enzyme Inhibitors/immunology |
description |
The essential oil of the leaves of Eugenia sulcata, in the Myrtaceae family, has a demonstrated antihypertensive effect, but its effects on heart muscle and its toxicity have not yet been elucidated. Little chemical or biological data are available for E. sulcata, whether emphasizing the beneficial effects or the pharmacological security of this species. This study aims to evaluate myocardial contractility and to analyze angiotensin converting enzyme (ACE) and myosin ATPase activities associated with use of this essential oil. In addition, we evaluated the immunotoxicity of E. sulcata essential oil. Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were treated daily for 30 days (10 mg/kg of oil) to evaluate the isometric force of the papillary muscle, ACE measured by fluorimetry, and myosin ATPase activities by inorganic phosphate. Lymphocyte cultures were used to evaluate cytotoxicity, DNA damage, and mutagenicity of the essential oil. The results demonstrate that the treatment did not change the cardiac contraction force and did not alter the functioning of the sarcoplasmic reticulum, extrusion of the membrane calcium, or modify the membrane calcium channels or β-adrenergic receptor activity. Tetanic contractions were potentiated in the SHR animals. Myosin ATPase activity was also increased in the SHR animals. Cardiac ACE activity was reduced in both animal strains, and the serum ACE was reduced only in the SHR animals. The essential oil did not cause cytotoxicity or mutagenicity and presented low DNA damage. Our results demonstrated that the essential oil does not change myocardial contractility and does not present relevant immunotoxicity. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164717 10.1590/s2175-97902019000117742 |
url |
https://www.revistas.usp.br/bjps/article/view/164717 |
identifier_str_mv |
10.1590/s2175-97902019000117742 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164717/157928 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17742 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17742 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17742 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222914467856384 |