In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L.
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/181718 |
Resumo: | Tanacetum balsamita locally called Shahesparam is an aromatic plant that grows widely in Azerbaijan Province, Iran. Due to the widespread use of T. balsamita as a pain killer and relief of inflammatory based disorders in Iranian folk medicine and considering the high content of essential oil in T. balsamita aerial parts, we were prompted to investigate the anti-nociceptive and anti-inflammatory properties of T. balsamita essential oil (TBEO) for the first time. The carrageenan-induced Paw Edema was used for inflammation evaluation in rat, and hot-plate method was used for pain assessment in mice. Different doses of TBEO were administered. Morphine and Mefenamic acid were used as the standard drugs in antinociceptive and anti-inflammatory evaluation tests, respectively. TBEO (100 mg/kg) showed significantly anti-nociceptive activity in hot-plate test. The anti-inflammatory activity of TBEO was found to be more than mefenamic acid. The studied oil was analyzed by GC and GC–MS. The major component of the oil was characterized as carvone (39.8%) which might be responsible for the observed activities. The results suggested that TBEO possessed biologically active constituents that had significant analgesic and anti-inflammatory effects which support the ethno-medicinal claims of the plant application in the management of pain and inflammation. |
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Brazilian Journal of Pharmaceutical Sciences |
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In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L.Tanacetum balsamitaEssential oilAnalgesicAntiinflammatoryTanacetum balsamita locally called Shahesparam is an aromatic plant that grows widely in Azerbaijan Province, Iran. Due to the widespread use of T. balsamita as a pain killer and relief of inflammatory based disorders in Iranian folk medicine and considering the high content of essential oil in T. balsamita aerial parts, we were prompted to investigate the anti-nociceptive and anti-inflammatory properties of T. balsamita essential oil (TBEO) for the first time. The carrageenan-induced Paw Edema was used for inflammation evaluation in rat, and hot-plate method was used for pain assessment in mice. Different doses of TBEO were administered. Morphine and Mefenamic acid were used as the standard drugs in antinociceptive and anti-inflammatory evaluation tests, respectively. TBEO (100 mg/kg) showed significantly anti-nociceptive activity in hot-plate test. The anti-inflammatory activity of TBEO was found to be more than mefenamic acid. The studied oil was analyzed by GC and GC–MS. The major component of the oil was characterized as carvone (39.8%) which might be responsible for the observed activities. The results suggested that TBEO possessed biologically active constituents that had significant analgesic and anti-inflammatory effects which support the ethno-medicinal claims of the plant application in the management of pain and inflammation.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18171810.1590/s2175-97902019000418357Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18357Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18357Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e183572175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181718/168676Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSharif, Maryam Najafizadeh, Parvaneh Asgarpanah, Jinous Mousavi, Zahra 2021-06-12T19:46:54Zoai:revistas.usp.br:article/181718Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L. |
title |
In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L. |
spellingShingle |
In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L. Sharif, Maryam Tanacetum balsamita Essential oil Analgesic Antiinflammatory |
title_short |
In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L. |
title_full |
In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L. |
title_fullStr |
In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L. |
title_full_unstemmed |
In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L. |
title_sort |
In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L. |
author |
Sharif, Maryam |
author_facet |
Sharif, Maryam Najafizadeh, Parvaneh Asgarpanah, Jinous Mousavi, Zahra |
author_role |
author |
author2 |
Najafizadeh, Parvaneh Asgarpanah, Jinous Mousavi, Zahra |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Sharif, Maryam Najafizadeh, Parvaneh Asgarpanah, Jinous Mousavi, Zahra |
dc.subject.por.fl_str_mv |
Tanacetum balsamita Essential oil Analgesic Antiinflammatory |
topic |
Tanacetum balsamita Essential oil Analgesic Antiinflammatory |
description |
Tanacetum balsamita locally called Shahesparam is an aromatic plant that grows widely in Azerbaijan Province, Iran. Due to the widespread use of T. balsamita as a pain killer and relief of inflammatory based disorders in Iranian folk medicine and considering the high content of essential oil in T. balsamita aerial parts, we were prompted to investigate the anti-nociceptive and anti-inflammatory properties of T. balsamita essential oil (TBEO) for the first time. The carrageenan-induced Paw Edema was used for inflammation evaluation in rat, and hot-plate method was used for pain assessment in mice. Different doses of TBEO were administered. Morphine and Mefenamic acid were used as the standard drugs in antinociceptive and anti-inflammatory evaluation tests, respectively. TBEO (100 mg/kg) showed significantly anti-nociceptive activity in hot-plate test. The anti-inflammatory activity of TBEO was found to be more than mefenamic acid. The studied oil was analyzed by GC and GC–MS. The major component of the oil was characterized as carvone (39.8%) which might be responsible for the observed activities. The results suggested that TBEO possessed biologically active constituents that had significant analgesic and anti-inflammatory effects which support the ethno-medicinal claims of the plant application in the management of pain and inflammation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181718 10.1590/s2175-97902019000418357 |
url |
https://www.revistas.usp.br/bjps/article/view/181718 |
identifier_str_mv |
10.1590/s2175-97902019000418357 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181718/168676 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18357 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18357 Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18357 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222915125313536 |