Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives

Detalhes bibliográficos
Autor(a) principal: Tay, Naime Funda
Data de Publicação: 2022
Outros Autores: Duran, Murat, Kayagil, İsmail, YURTTAŞ, Leyla, Göger, Gamze, Göger, Fatih, Demirci, Fatih, Demirayak, Şeref
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/204288
Resumo: In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.
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spelling Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivativesTriazoleThiazolePyridineAntimicrobial activityAntioxidant activityDPPH radical scavengingIn this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-11-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20428810.1590/s2175-97902022e191026Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/204288/194774Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTay, Naime FundaDuran, MuratKayagil, İsmailYURTTAŞ, LeylaGöger, GamzeGöger, FatihDemirci, FatihDemirayak, Şeref2023-06-05T13:26:04Zoai:revistas.usp.br:article/204288Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-06-05T13:26:04Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
title Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
spellingShingle Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
Tay, Naime Funda
Triazole
Thiazole
Pyridine
Antimicrobial activity
Antioxidant activity
DPPH radical scavenging
title_short Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
title_full Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
title_fullStr Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
title_full_unstemmed Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
title_sort Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
author Tay, Naime Funda
author_facet Tay, Naime Funda
Duran, Murat
Kayagil, İsmail
YURTTAŞ, Leyla
Göger, Gamze
Göger, Fatih
Demirci, Fatih
Demirayak, Şeref
author_role author
author2 Duran, Murat
Kayagil, İsmail
YURTTAŞ, Leyla
Göger, Gamze
Göger, Fatih
Demirci, Fatih
Demirayak, Şeref
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tay, Naime Funda
Duran, Murat
Kayagil, İsmail
YURTTAŞ, Leyla
Göger, Gamze
Göger, Fatih
Demirci, Fatih
Demirayak, Şeref
dc.subject.por.fl_str_mv Triazole
Thiazole
Pyridine
Antimicrobial activity
Antioxidant activity
DPPH radical scavenging
topic Triazole
Thiazole
Pyridine
Antimicrobial activity
Antioxidant activity
DPPH radical scavenging
description In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/204288
10.1590/s2175-97902022e191026
url https://www.revistas.usp.br/bjps/article/view/204288
identifier_str_mv 10.1590/s2175-97902022e191026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/204288/194774
dc.rights.driver.fl_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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