Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/204288 |
Resumo: | In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity. |
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Brazilian Journal of Pharmaceutical Sciences |
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Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivativesTriazoleThiazolePyridineAntimicrobial activityAntioxidant activityDPPH radical scavengingIn this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-11-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20428810.1590/s2175-97902022e191026Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/204288/194774Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTay, Naime FundaDuran, MuratKayagil, İsmailYURTTAŞ, LeylaGöger, GamzeGöger, FatihDemirci, FatihDemirayak, Şeref2023-06-05T13:26:04Zoai:revistas.usp.br:article/204288Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-06-05T13:26:04Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives |
title |
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives |
spellingShingle |
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives Tay, Naime Funda Triazole Thiazole Pyridine Antimicrobial activity Antioxidant activity DPPH radical scavenging |
title_short |
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives |
title_full |
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives |
title_fullStr |
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives |
title_full_unstemmed |
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives |
title_sort |
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives |
author |
Tay, Naime Funda |
author_facet |
Tay, Naime Funda Duran, Murat Kayagil, İsmail YURTTAŞ, Leyla Göger, Gamze Göger, Fatih Demirci, Fatih Demirayak, Şeref |
author_role |
author |
author2 |
Duran, Murat Kayagil, İsmail YURTTAŞ, Leyla Göger, Gamze Göger, Fatih Demirci, Fatih Demirayak, Şeref |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Tay, Naime Funda Duran, Murat Kayagil, İsmail YURTTAŞ, Leyla Göger, Gamze Göger, Fatih Demirci, Fatih Demirayak, Şeref |
dc.subject.por.fl_str_mv |
Triazole Thiazole Pyridine Antimicrobial activity Antioxidant activity DPPH radical scavenging |
topic |
Triazole Thiazole Pyridine Antimicrobial activity Antioxidant activity DPPH radical scavenging |
description |
In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/204288 10.1590/s2175-97902022e191026 |
url |
https://www.revistas.usp.br/bjps/article/view/204288 |
identifier_str_mv |
10.1590/s2175-97902022e191026 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/204288/194774 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1819596928358285312 |