Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats

Detalhes bibliográficos
Autor(a) principal: Oliani, Andrea Lucia Natali
Data de Publicação: 2015
Outros Autores: Dias, Lilian Mara Kirsch, Naves, Jeanete Lopes, Bernardi, Maria Martha, Oliveira, Claudio Alvarenga
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian Journal of Veterinary Research and Animal Science
Texto Completo: https://www.revistas.usp.br/bjvras/article/view/83354
Resumo: The effects of prenatal exposure to clomiphene citrate in sexual behavior, organ weight and hormone concentrations of male and female rats was evaluated. The animals received four doses of clomiphene citrate 2 mg/mL each during the prenatal period (21 days of gestation – DG21) on days 1 (DN1), 2 (DN2) and 3 (DN3) after the birth of the puppies. The treatment led to the development of polycystic ovaries in 70% of the females, masculinization of female sexual behavior and changes in sexual behavior of males evidenced by the reduction in the number of ejaculations. In regards to hormone levels, a decrease in the FSH levels in male offspring was observed. It was concluded that clomiphene citrate interferes with the reproductive capacity of male and female rats and female sexual orientation when prenatally administered.
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spelling Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female ratsEfeito da administração do citrato de clomifeno durante o período perinatal no comportamento sexual, peso dos órgãos e concentração hormonal de ratos Wistar machos e fêmeasDesruptores endócrinosAntiestrogênioComportamento homossexualEjaculaçãoEndocrine disruptorsAntiestrogenHomosexual behaviorEjaculationThe effects of prenatal exposure to clomiphene citrate in sexual behavior, organ weight and hormone concentrations of male and female rats was evaluated. The animals received four doses of clomiphene citrate 2 mg/mL each during the prenatal period (21 days of gestation – DG21) on days 1 (DN1), 2 (DN2) and 3 (DN3) after the birth of the puppies. The treatment led to the development of polycystic ovaries in 70% of the females, masculinization of female sexual behavior and changes in sexual behavior of males evidenced by the reduction in the number of ejaculations. In regards to hormone levels, a decrease in the FSH levels in male offspring was observed. It was concluded that clomiphene citrate interferes with the reproductive capacity of male and female rats and female sexual orientation when prenatally administered.Foram investigados os efeitos da exposição perinatal ao citrato de clomifeno no comportamento sexual, peso dos órgãos e concentração hormonal de ratos machos e fêmeas. Os animais receberam quatro doses de 2 mg/mL de citrato de clomifeno, no período perinatal (21 dias de gestação – DG21), nos dias 1 (DN1), 2 (DN2) e 3 (DN3) após o nascimento dos filhotes. O tratamento causou desenvolvimento de ovário policístico em 70% das fêmeas, masculinização do comportamento sexual das fêmeas e alteração do comportamento sexual dos machos evidenciado pela redução no número de ejaculações. Em relação aos níveis hormonais, observou-se diminuição de FSH na prole masculina. Concluiu-se que o citrato de clomifeno interfere na capacidade reprodutiva de ratos machos e fêmeas, e na orientação sexual de fêmeas, quando administrado perinatalmente.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2015-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/8335410.11606/issn.1678-4456.v52i2p141-150Brazilian Journal of Veterinary Research and Animal Science; Vol. 52 Núm. 2 (2015); 141-150Brazilian Journal of Veterinary Research and Animal Science; Vol. 52 No. 2 (2015); 141-150Brazilian Journal of Veterinary Research and Animal Science; v. 52 n. 2 (2015); 141-150Brazilian Journal of Veterinary Research and Animal Science; V. 52 N. 2 (2015); 141-1501678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPporhttps://www.revistas.usp.br/bjvras/article/view/83354/98295Copyright (c) 2015 Brazilian Journal of Veterinary Research and Animal Scienceinfo:eu-repo/semantics/openAccessOliani, Andrea Lucia NataliDias, Lilian Mara KirschNaves, Jeanete LopesBernardi, Maria MarthaOliveira, Claudio Alvarenga2020-06-23T04:05:35Zoai:revistas.usp.br:article/83354Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:52.886019Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false
dc.title.none.fl_str_mv Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats
Efeito da administração do citrato de clomifeno durante o período perinatal no comportamento sexual, peso dos órgãos e concentração hormonal de ratos Wistar machos e fêmeas
title Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats
spellingShingle Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats
Oliani, Andrea Lucia Natali
Desruptores endócrinos
Antiestrogênio
Comportamento homossexual
Ejaculação
Endocrine disruptors
Antiestrogen
Homosexual behavior
Ejaculation
title_short Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats
title_full Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats
title_fullStr Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats
title_full_unstemmed Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats
title_sort Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats
author Oliani, Andrea Lucia Natali
author_facet Oliani, Andrea Lucia Natali
Dias, Lilian Mara Kirsch
Naves, Jeanete Lopes
Bernardi, Maria Martha
Oliveira, Claudio Alvarenga
author_role author
author2 Dias, Lilian Mara Kirsch
Naves, Jeanete Lopes
Bernardi, Maria Martha
Oliveira, Claudio Alvarenga
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliani, Andrea Lucia Natali
Dias, Lilian Mara Kirsch
Naves, Jeanete Lopes
Bernardi, Maria Martha
Oliveira, Claudio Alvarenga
dc.subject.por.fl_str_mv Desruptores endócrinos
Antiestrogênio
Comportamento homossexual
Ejaculação
Endocrine disruptors
Antiestrogen
Homosexual behavior
Ejaculation
topic Desruptores endócrinos
Antiestrogênio
Comportamento homossexual
Ejaculação
Endocrine disruptors
Antiestrogen
Homosexual behavior
Ejaculation
description The effects of prenatal exposure to clomiphene citrate in sexual behavior, organ weight and hormone concentrations of male and female rats was evaluated. The animals received four doses of clomiphene citrate 2 mg/mL each during the prenatal period (21 days of gestation – DG21) on days 1 (DN1), 2 (DN2) and 3 (DN3) after the birth of the puppies. The treatment led to the development of polycystic ovaries in 70% of the females, masculinization of female sexual behavior and changes in sexual behavior of males evidenced by the reduction in the number of ejaculations. In regards to hormone levels, a decrease in the FSH levels in male offspring was observed. It was concluded that clomiphene citrate interferes with the reproductive capacity of male and female rats and female sexual orientation when prenatally administered.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/83354
10.11606/issn.1678-4456.v52i2p141-150
url https://www.revistas.usp.br/bjvras/article/view/83354
identifier_str_mv 10.11606/issn.1678-4456.v52i2p141-150
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/83354/98295
dc.rights.driver.fl_str_mv Copyright (c) 2015 Brazilian Journal of Veterinary Research and Animal Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2015 Brazilian Journal of Veterinary Research and Animal Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science; Vol. 52 Núm. 2 (2015); 141-150
Brazilian Journal of Veterinary Research and Animal Science; Vol. 52 No. 2 (2015); 141-150
Brazilian Journal of Veterinary Research and Animal Science; v. 52 n. 2 (2015); 141-150
Brazilian Journal of Veterinary Research and Animal Science; V. 52 N. 2 (2015); 141-150
1678-4456
1413-9596
reponame:Brazilian Journal of Veterinary Research and Animal Science
instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron:USP
instname_str Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Veterinary Research and Animal Science
collection Brazilian Journal of Veterinary Research and Animal Science
repository.name.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
repository.mail.fl_str_mv bjvras@usp.br
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