Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/26835 |
Resumo: | This work has evaluated the hematological and biochemical profile by the use of sodium diclofenac, meloxicam and firocoxib in Wistar rats. The rats were distributed in groups: G1 (control), G2 (diclofenac sodium: 15 mg/kg), G3 (meloxicam: 2.0 mg/ kg), G4 (meloxicam: 10.0 mg/ kg), G5 (firocoxib: 5.0 mg/ kg) e G6 (firocoxib: 25.0 mg/ kg). The drugs were administered intragastrically (gavage) once a day, during five days and evaluated in three moments: M1 (48 hours after the beginning of the treatment), M2 (96 hours after the beginning of the treatment) and M3 (72 hours after the ending of the treatment). In each moment of each group, five to seven animals were evaluated and laboratory exams were performed. There were no significant changes observed in the biochemical and hematological parameters by the use of meloxicam and firocoxib. One of the effects of the sodium diclofenac was eritrogram variation as hematocrit, erythrocytes, hemoglobin decrease during the treatment. In addition, the platelets and total white blood cells counts did not change except for basophil. There was no changes in AST, ALP, GGT, urea, creatinine, sodium, potassium values. However, the values of protein, globulin and albumin decreased. It was concluded that diclofenac sodium does not provide large variations in the hemogram and biochemical profile than the meloxicam and firocoxib do not provide delletery effects in laboratories tests. |
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Brazilian Journal of Veterinary Research and Animal Science |
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Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in ratsAvaliações hematológicas e bioquímicas do uso de diclofenaco de sódio, meloxicam e firocoxibe em ratosDiclofenaco de sódioMeloxicamFirocoxibeExames laboratoriaisRatosSodium diclofenacMeloxicamFirocoxibLaboratories parametersRatsThis work has evaluated the hematological and biochemical profile by the use of sodium diclofenac, meloxicam and firocoxib in Wistar rats. The rats were distributed in groups: G1 (control), G2 (diclofenac sodium: 15 mg/kg), G3 (meloxicam: 2.0 mg/ kg), G4 (meloxicam: 10.0 mg/ kg), G5 (firocoxib: 5.0 mg/ kg) e G6 (firocoxib: 25.0 mg/ kg). The drugs were administered intragastrically (gavage) once a day, during five days and evaluated in three moments: M1 (48 hours after the beginning of the treatment), M2 (96 hours after the beginning of the treatment) and M3 (72 hours after the ending of the treatment). In each moment of each group, five to seven animals were evaluated and laboratory exams were performed. There were no significant changes observed in the biochemical and hematological parameters by the use of meloxicam and firocoxib. One of the effects of the sodium diclofenac was eritrogram variation as hematocrit, erythrocytes, hemoglobin decrease during the treatment. In addition, the platelets and total white blood cells counts did not change except for basophil. There was no changes in AST, ALP, GGT, urea, creatinine, sodium, potassium values. However, the values of protein, globulin and albumin decreased. It was concluded that diclofenac sodium does not provide large variations in the hemogram and biochemical profile than the meloxicam and firocoxib do not provide delletery effects in laboratories tests.O presente trabalho avaliou os parâmetros hematológicos e bioquímicos do uso de diclofenaco de sódio, meloxicam e firocoxibe em ratos Wistar. Os ratos foram distribuídos em grupos: G1 (controle), G2 (diclofenaco de sódio: 15 mg/kg), G3 (meloxicam: 2,0 mg/ kg), G4 (meloxicam: 10,0 mg/ kg), G5 (firocoxibe: 5,0 mg/ kg) e G6 (firocoxibe: 25,0 mg/ kg). Os fármacos foram administrados por via intragástrica (gavage) a cada 24 horas, durante cinco dias e avaliados em três momentos: M1 (48 horas após o início do tratamento), M2 (96 horas após o início do tratamento) e M3 (72 horas após o término do tratamento). Em cada momento de cada grupo, foram avaliados de cinco a sete animais e realizados os exames laboratoriais. Não foram observadas alterações significativas nos parâmetros bioquímicos e hematológicos com o uso de meloxicam e firocoxibe. O diclofenaco de sódio produziu alterações no eritrograma (redução de hemácias, hematócrito e na taxa de hemoglobina) durante o tratamento e não alterou a contagem das plaquetas e leucometria, com exceção dos basófilos. Não produziu alterações nas atividades de AST, FA, GGT, ureia, creatinina, sódio e potássio. Entretanto, causou diminuições das proteínas plasmática e total sérica, albumina e globulina. Conclui-se que o diclofenaco de sódio não produz grandes alterações no hemograma e exames bioquímicos, enquanto que, o meloxicam e o firocoxibe não produzem alterações e efeitos deletérios dose-dependentes nestes exames laboratoriais.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/2683510.11606/issn.1678-4456.bjvras.2010.26835Brazilian Journal of Veterinary Research and Animal Science; Vol. 47 Núm. 2 (2010); 117-124Brazilian Journal of Veterinary Research and Animal Science; Vol. 47 No. 2 (2010); 117-124Brazilian Journal of Veterinary Research and Animal Science; v. 47 n. 2 (2010); 117-124Brazilian Journal of Veterinary Research and Animal Science; V. 47 N. 2 (2010); 117-1241678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPporhttps://www.revistas.usp.br/bjvras/article/view/26835/28618Barbosa, Cristiane MoraesSakate, MichikoCamplesi, Annelise CarlaVailati, Maria do Carmo FernandezMoraes, Lívia FagundesTakahira, Regina Kiomiinfo:eu-repo/semantics/openAccess2020-06-23T04:10:53Zoai:revistas.usp.br:article/26835Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:06.794642Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats Avaliações hematológicas e bioquímicas do uso de diclofenaco de sódio, meloxicam e firocoxibe em ratos |
title |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
spellingShingle |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats Barbosa, Cristiane Moraes Diclofenaco de sódio Meloxicam Firocoxibe Exames laboratoriais Ratos Sodium diclofenac Meloxicam Firocoxib Laboratories parameters Rats |
title_short |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_full |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_fullStr |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_full_unstemmed |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_sort |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
author |
Barbosa, Cristiane Moraes |
author_facet |
Barbosa, Cristiane Moraes Sakate, Michiko Camplesi, Annelise Carla Vailati, Maria do Carmo Fernandez Moraes, Lívia Fagundes Takahira, Regina Kiomi |
author_role |
author |
author2 |
Sakate, Michiko Camplesi, Annelise Carla Vailati, Maria do Carmo Fernandez Moraes, Lívia Fagundes Takahira, Regina Kiomi |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Barbosa, Cristiane Moraes Sakate, Michiko Camplesi, Annelise Carla Vailati, Maria do Carmo Fernandez Moraes, Lívia Fagundes Takahira, Regina Kiomi |
dc.subject.por.fl_str_mv |
Diclofenaco de sódio Meloxicam Firocoxibe Exames laboratoriais Ratos Sodium diclofenac Meloxicam Firocoxib Laboratories parameters Rats |
topic |
Diclofenaco de sódio Meloxicam Firocoxibe Exames laboratoriais Ratos Sodium diclofenac Meloxicam Firocoxib Laboratories parameters Rats |
description |
This work has evaluated the hematological and biochemical profile by the use of sodium diclofenac, meloxicam and firocoxib in Wistar rats. The rats were distributed in groups: G1 (control), G2 (diclofenac sodium: 15 mg/kg), G3 (meloxicam: 2.0 mg/ kg), G4 (meloxicam: 10.0 mg/ kg), G5 (firocoxib: 5.0 mg/ kg) e G6 (firocoxib: 25.0 mg/ kg). The drugs were administered intragastrically (gavage) once a day, during five days and evaluated in three moments: M1 (48 hours after the beginning of the treatment), M2 (96 hours after the beginning of the treatment) and M3 (72 hours after the ending of the treatment). In each moment of each group, five to seven animals were evaluated and laboratory exams were performed. There were no significant changes observed in the biochemical and hematological parameters by the use of meloxicam and firocoxib. One of the effects of the sodium diclofenac was eritrogram variation as hematocrit, erythrocytes, hemoglobin decrease during the treatment. In addition, the platelets and total white blood cells counts did not change except for basophil. There was no changes in AST, ALP, GGT, urea, creatinine, sodium, potassium values. However, the values of protein, globulin and albumin decreased. It was concluded that diclofenac sodium does not provide large variations in the hemogram and biochemical profile than the meloxicam and firocoxib do not provide delletery effects in laboratories tests. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/26835 10.11606/issn.1678-4456.bjvras.2010.26835 |
url |
https://www.revistas.usp.br/bjvras/article/view/26835 |
identifier_str_mv |
10.11606/issn.1678-4456.bjvras.2010.26835 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/26835/28618 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 47 Núm. 2 (2010); 117-124 Brazilian Journal of Veterinary Research and Animal Science; Vol. 47 No. 2 (2010); 117-124 Brazilian Journal of Veterinary Research and Animal Science; v. 47 n. 2 (2010); 117-124 Brazilian Journal of Veterinary Research and Animal Science; V. 47 N. 2 (2010); 117-124 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
_version_ |
1797051559537803264 |