Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/26722 |
Resumo: | The embryotoxic effects of prenatal daily exposure to 0.0, 0.7, 3.0 or 15.0 mg/kg of the aqueous extract (AQE) from Ipomoea carnea (I. carnea) dried leaves on gestational days 521 were studied in rats. Maternal reproductive performance, skeletal and visceral abnormalities, and malformations were evaluated. Moreover, anatomopathological findings in dams following the treatment were recorded. Regarding the dams, our results show that body weight, weight gain, food and water consumption, and reproductive performance were all unaffected by exposure to the different doses of the AQE. Nonetheless, dams treated with AQE presented a dose-dependent cytoplasmic vacuolation in the liver, kidneys, thyroid and adrenal glands. Fetal examination did not show external abnormalities or malformations. Evidences of several skeletal and visceral abnormalities were found, particularly after the higher dose of AQE. A reduced ossification centers were also detected. The present data show that prenatal ingestion of the I. carnea AQE in rats induces embryotoxicity. These effects are attributed to an active principle from I. carnea acting on maternal homeostasis, or directly in the conception. |
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Brazilian Journal of Veterinary Research and Animal Science |
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Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in ratsEfeitos embriotóxicos do tratamento pré-natal com extrato aquoso de Ipomoea carnea em ratosIpomoeaTeratogensPrenatal careIpomeaTeratogênicosCuidado pré-natalThe embryotoxic effects of prenatal daily exposure to 0.0, 0.7, 3.0 or 15.0 mg/kg of the aqueous extract (AQE) from Ipomoea carnea (I. carnea) dried leaves on gestational days 521 were studied in rats. Maternal reproductive performance, skeletal and visceral abnormalities, and malformations were evaluated. Moreover, anatomopathological findings in dams following the treatment were recorded. Regarding the dams, our results show that body weight, weight gain, food and water consumption, and reproductive performance were all unaffected by exposure to the different doses of the AQE. Nonetheless, dams treated with AQE presented a dose-dependent cytoplasmic vacuolation in the liver, kidneys, thyroid and adrenal glands. Fetal examination did not show external abnormalities or malformations. Evidences of several skeletal and visceral abnormalities were found, particularly after the higher dose of AQE. A reduced ossification centers were also detected. The present data show that prenatal ingestion of the I. carnea AQE in rats induces embryotoxicity. These effects are attributed to an active principle from I. carnea acting on maternal homeostasis, or directly in the conception.Os efeitos embriotóxicos da exposição diária pré-natal a 0,0, 0,7, 3,0 ou 15,0mg/kg do extrato aquoso da I. carnea nos dias 5 a 21 de gestação foram estudados. Foram avaliados a performance reprodutiva materna, anormalidades esqueléticas e viscerais e malformações. Além disso, após o tratamento foram encontrados achados anatomopatológicos. Em relação às ratas mães, nossos resultados mostraram que a exposição às diferentes doses não afetou o peso corporal, ganho de peso, consumos de água e ração e performance reprodutiva. Apesar disso, apresentaram vacuolização citoplasmática de forma dose-dependente em fígado, rins, tireóide e glândula adrenal. Exames fetais não mostraram anormalidades externas ou malformações, sendo somente encontradas evidências de anormalidades esqueléticas e viscerais após altas doses do extrato. Foi observada redução dos centros de ossificação. Os presentes dados mostram que a ingestão prenatal do extrato de I. carnea induz embriotoxicidade. Estes efeitos são atribuídos à ação na homeostase maternal ou diretamente na concepção.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2008-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/2672210.11606/issn.1678-4456.bjvras.2008.26722Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 Núm. 1 (2008); 67-75Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 No. 1 (2008); 67-75Brazilian Journal of Veterinary Research and Animal Science; v. 45 n. 1 (2008); 67-75Brazilian Journal of Veterinary Research and Animal Science; V. 45 N. 1 (2008); 67-751678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPenghttps://www.revistas.usp.br/bjvras/article/view/26722/28505Hosomi, Rosana ZorikiSpinosa, Helenice de SouzaGórniak, Silvana LimaHabr, Soraya FerreiraPenteado, Sandra WitakerVaroli, Franci Mary FantinatoBernardi, Maria Marthainfo:eu-repo/semantics/openAccess2020-06-23T04:13:49Zoai:revistas.usp.br:article/26722Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:00.042470Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats Efeitos embriotóxicos do tratamento pré-natal com extrato aquoso de Ipomoea carnea em ratos |
title |
Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats |
spellingShingle |
Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats Hosomi, Rosana Zoriki Ipomoea Teratogens Prenatal care Ipomea Teratogênicos Cuidado pré-natal |
title_short |
Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats |
title_full |
Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats |
title_fullStr |
Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats |
title_full_unstemmed |
Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats |
title_sort |
Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats |
author |
Hosomi, Rosana Zoriki |
author_facet |
Hosomi, Rosana Zoriki Spinosa, Helenice de Souza Górniak, Silvana Lima Habr, Soraya Ferreira Penteado, Sandra Witaker Varoli, Franci Mary Fantinato Bernardi, Maria Martha |
author_role |
author |
author2 |
Spinosa, Helenice de Souza Górniak, Silvana Lima Habr, Soraya Ferreira Penteado, Sandra Witaker Varoli, Franci Mary Fantinato Bernardi, Maria Martha |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Hosomi, Rosana Zoriki Spinosa, Helenice de Souza Górniak, Silvana Lima Habr, Soraya Ferreira Penteado, Sandra Witaker Varoli, Franci Mary Fantinato Bernardi, Maria Martha |
dc.subject.por.fl_str_mv |
Ipomoea Teratogens Prenatal care Ipomea Teratogênicos Cuidado pré-natal |
topic |
Ipomoea Teratogens Prenatal care Ipomea Teratogênicos Cuidado pré-natal |
description |
The embryotoxic effects of prenatal daily exposure to 0.0, 0.7, 3.0 or 15.0 mg/kg of the aqueous extract (AQE) from Ipomoea carnea (I. carnea) dried leaves on gestational days 521 were studied in rats. Maternal reproductive performance, skeletal and visceral abnormalities, and malformations were evaluated. Moreover, anatomopathological findings in dams following the treatment were recorded. Regarding the dams, our results show that body weight, weight gain, food and water consumption, and reproductive performance were all unaffected by exposure to the different doses of the AQE. Nonetheless, dams treated with AQE presented a dose-dependent cytoplasmic vacuolation in the liver, kidneys, thyroid and adrenal glands. Fetal examination did not show external abnormalities or malformations. Evidences of several skeletal and visceral abnormalities were found, particularly after the higher dose of AQE. A reduced ossification centers were also detected. The present data show that prenatal ingestion of the I. carnea AQE in rats induces embryotoxicity. These effects are attributed to an active principle from I. carnea acting on maternal homeostasis, or directly in the conception. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/26722 10.11606/issn.1678-4456.bjvras.2008.26722 |
url |
https://www.revistas.usp.br/bjvras/article/view/26722 |
identifier_str_mv |
10.11606/issn.1678-4456.bjvras.2008.26722 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/26722/28505 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 Núm. 1 (2008); 67-75 Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 No. 1 (2008); 67-75 Brazilian Journal of Veterinary Research and Animal Science; v. 45 n. 1 (2008); 67-75 Brazilian Journal of Veterinary Research and Animal Science; V. 45 N. 1 (2008); 67-75 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
_version_ |
1797051558912851968 |