Participation of the pathway alfa-2

Detalhes bibliográficos
Autor(a) principal: Batista, Emiliana de Oliveira Santana
Data de Publicação: 2011
Outros Autores: Cardoso, Daniel, Nogueira, Guilherme de Paula
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian Journal of Veterinary Research and Animal Science
Texto Completo: https://www.revistas.usp.br/bjvras/article/view/34397
Resumo: This study investigated GH secretion after clonidine (alpha-2 adrenergic agonist) treatmentin pre-pubertal Nelore heifers. Clonidine (10mg/kg, IV, 15 min samples for 4h) was administrated in the same Nelore heifers at eight (n = 4), 12 (n = 5) and 15 (n = 4) months of age. The GH concentration was measured by radioimmunoassay (sensivity = 0.25 ng/mL, CV = 16%). At eight months, clonidine increased GH average concentration, total area of peaks, the total area of GH secretion and increased peak amplitude and reduced time to onset of peak (P < 0.05). At 15 months, the administration of clonidine increased the GH average concentration and at 12 months the increased occurred only in restricted intervals (P
id USP-49_dd264f2d76cdcd16e9c82724f119fa3f
oai_identifier_str oai:revistas.usp.br:article/34397
network_acronym_str USP-49
network_name_str Brazilian Journal of Veterinary Research and Animal Science
repository_id_str https://www.revistas.usp.br/bjvras/index
spelling Participation of the pathway alfa-2Participação da via alfa-2 adrenérgica no controle da secreção do hormônio do crescimento no período pré-púbere em novilhas da raça Nelore: adrenergic in the control of growth hormone secretion in the pre-puberty period of the Nellore heifersNelorePré-puberdadeGHClonidinaNelorePrepubertalGHClonidineThis study investigated GH secretion after clonidine (alpha-2 adrenergic agonist) treatmentin pre-pubertal Nelore heifers. Clonidine (10mg/kg, IV, 15 min samples for 4h) was administrated in the same Nelore heifers at eight (n = 4), 12 (n = 5) and 15 (n = 4) months of age. The GH concentration was measured by radioimmunoassay (sensivity = 0.25 ng/mL, CV = 16%). At eight months, clonidine increased GH average concentration, total area of peaks, the total area of GH secretion and increased peak amplitude and reduced time to onset of peak (P < 0.05). At 15 months, the administration of clonidine increased the GH average concentration and at 12 months the increased occurred only in restricted intervals (P O objetivo deste trabalho foi investigar a variação na secreção de GH em resposta ao tratamento com clonidina, agonista alfa-2 adrenérgico, no período pré-púbere de novilhas da raça Nelore, e desta forma obter informações neuroendócrinas envolvidas no processo de maturação sexual destes animais. A administração de clonidina (10 µg/kg, I.V., amostras 15 min por 4h) foi feita nas novilhas aos oito (n =4), 12(n = 5) e 15 meses de idade (n = 4). A concentração de GH foi quantificada por radioimunoensaio (sensibilidade = 0,25 ng/mL, CV = 16%). Aos oito meses, a administração do estimulador alfa-2 adrenérgico aumentou a concentração de GH, área total de picos, área total de secreção de GH e amplitude do maior pico e reduziu o tempo para aparecimento de pico (P &lt; 0,05). A administração de clonidina aumentou a concentração de GH aos 15 meses, e aos 12 meses, em intervalos restritos (P &lt; 0,05). O uso da clonidina estimulou a secreção de GH em novilhas Nelore pré-púberes. Este efeito foi mais evidente nas novilhas aos oito meses, comparado aos 12 e 15 meses de idade.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/3439710.11606/S1413-95962011000400008Brazilian Journal of Veterinary Research and Animal Science; Vol. 48 Núm. 4 (2011); 325-331Brazilian Journal of Veterinary Research and Animal Science; Vol. 48 No. 4 (2011); 325-331Brazilian Journal of Veterinary Research and Animal Science; v. 48 n. 4 (2011); 325-331Brazilian Journal of Veterinary Research and Animal Science; V. 48 N. 4 (2011); 325-3311678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPporhttps://www.revistas.usp.br/bjvras/article/view/34397/37135Batista, Emiliana de Oliveira SantanaCardoso, DanielNogueira, Guilherme de Paulainfo:eu-repo/semantics/openAccess2020-06-23T04:09:14Zoai:revistas.usp.br:article/34397Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:11.486427Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false
dc.title.none.fl_str_mv Participation of the pathway alfa-2
Participação da via alfa-2 adrenérgica no controle da secreção do hormônio do crescimento no período pré-púbere em novilhas da raça Nelore: adrenergic in the control of growth hormone secretion in the pre-puberty period of the Nellore heifers
title Participation of the pathway alfa-2
spellingShingle Participation of the pathway alfa-2
Batista, Emiliana de Oliveira Santana
Nelore
Pré-puberdade
GH
Clonidina
Nelore
Prepubertal
GH
Clonidine
title_short Participation of the pathway alfa-2
title_full Participation of the pathway alfa-2
title_fullStr Participation of the pathway alfa-2
title_full_unstemmed Participation of the pathway alfa-2
title_sort Participation of the pathway alfa-2
author Batista, Emiliana de Oliveira Santana
author_facet Batista, Emiliana de Oliveira Santana
Cardoso, Daniel
Nogueira, Guilherme de Paula
author_role author
author2 Cardoso, Daniel
Nogueira, Guilherme de Paula
author2_role author
author
dc.contributor.author.fl_str_mv Batista, Emiliana de Oliveira Santana
Cardoso, Daniel
Nogueira, Guilherme de Paula
dc.subject.por.fl_str_mv Nelore
Pré-puberdade
GH
Clonidina
Nelore
Prepubertal
GH
Clonidine
topic Nelore
Pré-puberdade
GH
Clonidina
Nelore
Prepubertal
GH
Clonidine
description This study investigated GH secretion after clonidine (alpha-2 adrenergic agonist) treatmentin pre-pubertal Nelore heifers. Clonidine (10mg/kg, IV, 15 min samples for 4h) was administrated in the same Nelore heifers at eight (n = 4), 12 (n = 5) and 15 (n = 4) months of age. The GH concentration was measured by radioimmunoassay (sensivity = 0.25 ng/mL, CV = 16%). At eight months, clonidine increased GH average concentration, total area of peaks, the total area of GH secretion and increased peak amplitude and reduced time to onset of peak (P < 0.05). At 15 months, the administration of clonidine increased the GH average concentration and at 12 months the increased occurred only in restricted intervals (P
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/34397
10.11606/S1413-95962011000400008
url https://www.revistas.usp.br/bjvras/article/view/34397
identifier_str_mv 10.11606/S1413-95962011000400008
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/34397/37135
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science; Vol. 48 Núm. 4 (2011); 325-331
Brazilian Journal of Veterinary Research and Animal Science; Vol. 48 No. 4 (2011); 325-331
Brazilian Journal of Veterinary Research and Animal Science; v. 48 n. 4 (2011); 325-331
Brazilian Journal of Veterinary Research and Animal Science; V. 48 N. 4 (2011); 325-331
1678-4456
1413-9596
reponame:Brazilian Journal of Veterinary Research and Animal Science
instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron:USP
instname_str Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Veterinary Research and Animal Science
collection Brazilian Journal of Veterinary Research and Animal Science
repository.name.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
repository.mail.fl_str_mv bjvras@usp.br
_version_ 1797051560066285568