Evaluation of the efficacy of hyperimmune bovine colostrum on Cryptosporidium parvum experimental infection of rodents

• Autor(a) principal: Abreu, Vicente José Salles de
• Data de Publicação: 2003
• Outros Autores: Cardoso, Ary Lopes, Pena, Hilda Fátima de Jesus, Gennari, Solange Maria, Sinhorini, Idércio, Damy, Sueli Blanes
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Veterinary Research and Animal Science
• Texto Completo: https://www.revistas.usp.br/bjvras/article/view/11413
• topic: Colostrum; Diseases animal models; Cryptosporidium parvum; Rodents; F344 endogamic rats; Colostro; Modelos animais de doenças; Cryptosporidium parvum; Roedores; Ratos endogâmicos F344

The hyperimmune bovine colostrum has a high concentration of antibodies anti-Cryptosporidium parvum. This product is considered one of the promising therapeutic strategies in the control of intestinal cryptosporidiosis in humans. With the purpose to evaluate the hyperimmune bovine colostrum efficacy in reducing the parasitism and preventing intestinal mucosa alterations, several strains of rats F344 and mice were experimentally infected with Cryptosporidium parvum oocysts. The results showed that the hyperimmune bovine colostrum had high levels of antibodies. The rats F344, treated either with hyperimmune or normal bovine colostrum, had reduction of the intestinal parasitism and presented little mucosa compromise. The mice C57BL/6 when treated either with hyperimmune or normal colostrum had slight reduction of the intestinal parasitism and evidenced no statistical significant differences in the histopathological mucosa changes. In conclusion, the use of hyperimmune bovine colostrum has a limited benefit in Cryptosporidium parvum infection.