Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Odontologia da Universidade de São Paulo |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-06631999000300003 |
Resumo: | The increasing number of oral infections due to opportunistic fungi in immunocompromised patients, needs a new evaluation of the drugs in use. The susceptibility in vitro of Candida albicans strains from the oral mucosa of cancer patients to amphotericin B, ketoconazole, miconazole, fluconazole and itraconazole were evaluated. A dilution technique in YNB agar or subculture on Sabouraud agar was utilised for MIC or MFC determinations. With this methodology, the best fungicidal drug for C.albicans collected from the oral mucosa of 40 cancer patients, divided in two groups: one treated by radiotherapy and the other not, the best results were obtained with amphotericin B, presenting low values of MIC compared to azoles and MFC values. However it is important to take into consideration the utilisation in vivo of this polyenic antibiotic and the possible toxic levels necessary to achieve good results. The coexistence of other fungi and the local conditions must also be pondered with these patients, who are mostly undergoing radiotherapy. In order to achieve better results without undesirable consequences, higher levels of MIC are expected with the daily clinical use of new drugs. |
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Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancerCandida albicansOpportunistic infectionsAntifungal agentsNeoplasmsThe increasing number of oral infections due to opportunistic fungi in immunocompromised patients, needs a new evaluation of the drugs in use. The susceptibility in vitro of Candida albicans strains from the oral mucosa of cancer patients to amphotericin B, ketoconazole, miconazole, fluconazole and itraconazole were evaluated. A dilution technique in YNB agar or subculture on Sabouraud agar was utilised for MIC or MFC determinations. With this methodology, the best fungicidal drug for C.albicans collected from the oral mucosa of 40 cancer patients, divided in two groups: one treated by radiotherapy and the other not, the best results were obtained with amphotericin B, presenting low values of MIC compared to azoles and MFC values. However it is important to take into consideration the utilisation in vivo of this polyenic antibiotic and the possible toxic levels necessary to achieve good results. The coexistence of other fungi and the local conditions must also be pondered with these patients, who are mostly undergoing radiotherapy. In order to achieve better results without undesirable consequences, higher levels of MIC are expected with the daily clinical use of new drugs.Universidade de São Paulo1999-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-06631999000300003Revista de Odontologia da Universidade de São Paulo v.13 n.3 1999reponame:Revista de Odontologia da Universidade de São Pauloinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0103-06631999000300003info:eu-repo/semantics/openAccessCOSTA,Lino João daBIRMAN,Esther GoldenbergALVES,Sidney HartzCURY,Arlete Emilyeng1999-12-08T00:00:00Zoai:scielo:S0103-06631999000300003Revistahttps://www.scielo.br/j/rousp/PUBhttps://old.scielo.br/oai/scielo-oai.php||pob@edu.usp.br0103-06630103-0663opendoar:1999-12-08T00:00Revista de Odontologia da Universidade de São Paulo - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer |
title |
Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer |
spellingShingle |
Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer COSTA,Lino João da Candida albicans Opportunistic infections Antifungal agents Neoplasms |
title_short |
Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer |
title_full |
Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer |
title_fullStr |
Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer |
title_full_unstemmed |
Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer |
title_sort |
Antifungal susceptibility of Candida albicans isolated from oral mucosa of patients with cancer |
author |
COSTA,Lino João da |
author_facet |
COSTA,Lino João da BIRMAN,Esther Goldenberg ALVES,Sidney Hartz CURY,Arlete Emily |
author_role |
author |
author2 |
BIRMAN,Esther Goldenberg ALVES,Sidney Hartz CURY,Arlete Emily |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
COSTA,Lino João da BIRMAN,Esther Goldenberg ALVES,Sidney Hartz CURY,Arlete Emily |
dc.subject.por.fl_str_mv |
Candida albicans Opportunistic infections Antifungal agents Neoplasms |
topic |
Candida albicans Opportunistic infections Antifungal agents Neoplasms |
description |
The increasing number of oral infections due to opportunistic fungi in immunocompromised patients, needs a new evaluation of the drugs in use. The susceptibility in vitro of Candida albicans strains from the oral mucosa of cancer patients to amphotericin B, ketoconazole, miconazole, fluconazole and itraconazole were evaluated. A dilution technique in YNB agar or subculture on Sabouraud agar was utilised for MIC or MFC determinations. With this methodology, the best fungicidal drug for C.albicans collected from the oral mucosa of 40 cancer patients, divided in two groups: one treated by radiotherapy and the other not, the best results were obtained with amphotericin B, presenting low values of MIC compared to azoles and MFC values. However it is important to take into consideration the utilisation in vivo of this polyenic antibiotic and the possible toxic levels necessary to achieve good results. The coexistence of other fungi and the local conditions must also be pondered with these patients, who are mostly undergoing radiotherapy. In order to achieve better results without undesirable consequences, higher levels of MIC are expected with the daily clinical use of new drugs. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-06631999000300003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-06631999000300003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-06631999000300003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo |
dc.source.none.fl_str_mv |
Revista de Odontologia da Universidade de São Paulo v.13 n.3 1999 reponame:Revista de Odontologia da Universidade de São Paulo instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Odontologia da Universidade de São Paulo |
collection |
Revista de Odontologia da Universidade de São Paulo |
repository.name.fl_str_mv |
Revista de Odontologia da Universidade de São Paulo - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||pob@edu.usp.br |
_version_ |
1754821051578056704 |