Necrolytic migratory erythema associated with glucagonoma syndrome: a case report

• Autor(a) principal: Dal Coleto,Cassio C.
• Data de Publicação: 2001
• Outros Autores: Mello,Ana Paula F. de, Piquero-Casals,Jaime, Lima,Fábio R., Vilela,Maria Aparecida Constantino, Festa-Neto,Cyro, Sanches Jr.,José Antonio
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Revista do Hospital das Clínicas
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812001000600005
• topic: Necrolytic migratory erythema; Glucagonoma syndrome; Glucagonoma

Necrolytic migratory erythema is a rare skin condition that consists of migrating areas of erythema with blisters that heal with hyperpigmentation. It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome. We describe a 52-year-old female patient with necrolytic migratory erythema associated with glucagonoma syndrome who had metastatic disease at presentation and passed away one week after her admission. The autopsy showed a tumor in the body of the pancreas, which was diagnosed as a neuroendocrine tumor and confirmed by immunohistochemistry. The diagnosis of necrolytic migratory erythema is a matter of great importance, since it might be an auxiliary tool for the early detection of glucagonoma.