Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation

Detalhes bibliográficos
Autor(a) principal: Coelho,Fabricio Ferreira
Data de Publicação: 2003
Outros Autores: Coelho,Rafael Ferreira, Massarollo,Paulo Celso Bosco, Mies,Sérgio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Hospital das Clínicas
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000300003
Resumo: PURPOSE: To study the indications and results of tacrolimus as rescue therapy for acute cellular or chronic rejection in liver transplantation. PATIENTS AND METHODS: Eighteen liver transplant recipients who underwent rescue therapy with tacrolimus between March 1995 and August 1999 were retrospectively studied. The treatment indication, patients, and graft situation were recorded as of October 31st, 1999. The response to tacrolimus was defined as patient survival with a functional graft and histological reversal of acute cellular, or for chronic rejection, bilirubin serum levels decreasing to up to twice the upper normal limit. RESULTS: Fourteen cases (77.8%) presented a good response. The response rate for the different indications was: (1) acute cellular + sepsis - 0/1 case; (2) recurrent acute cellular - 1/1 case; (3) OKT3-resistant acute cellular - 2/2 cases; (4) steroid-resistant acute cellular + active viral infection - 3/3 cases; (5) chronic rejection - 8/11 cases (72.7% response rate). The 4 patients who did not respond died. CONCLUSION: Tacrolimus rescue therapy was successful in most cases of acute cellular and chronic rejection in liver transplantation.
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spelling Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantationLiver transplantationAdverse effectsImmunosuppressionTacrolimusTherapeutic usePURPOSE: To study the indications and results of tacrolimus as rescue therapy for acute cellular or chronic rejection in liver transplantation. PATIENTS AND METHODS: Eighteen liver transplant recipients who underwent rescue therapy with tacrolimus between March 1995 and August 1999 were retrospectively studied. The treatment indication, patients, and graft situation were recorded as of October 31st, 1999. The response to tacrolimus was defined as patient survival with a functional graft and histological reversal of acute cellular, or for chronic rejection, bilirubin serum levels decreasing to up to twice the upper normal limit. RESULTS: Fourteen cases (77.8%) presented a good response. The response rate for the different indications was: (1) acute cellular + sepsis - 0/1 case; (2) recurrent acute cellular - 1/1 case; (3) OKT3-resistant acute cellular - 2/2 cases; (4) steroid-resistant acute cellular + active viral infection - 3/3 cases; (5) chronic rejection - 8/11 cases (72.7% response rate). The 4 patients who did not respond died. CONCLUSION: Tacrolimus rescue therapy was successful in most cases of acute cellular and chronic rejection in liver transplantation.Faculdade de Medicina / Universidade de São Paulo - FM/USP2003-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000300003Revista do Hospital das Clínicas v.58 n.3 2003reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812003000300003info:eu-repo/semantics/openAccessCoelho,Fabricio FerreiraCoelho,Rafael FerreiraMassarollo,Paulo Celso BoscoMies,Sérgioeng2003-07-22T00:00:00Zoai:scielo:S0041-87812003000300003Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2003-07-22T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
title Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
spellingShingle Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
Coelho,Fabricio Ferreira
Liver transplantation
Adverse effects
Immunosuppression
Tacrolimus
Therapeutic use
title_short Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
title_full Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
title_fullStr Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
title_full_unstemmed Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
title_sort Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
author Coelho,Fabricio Ferreira
author_facet Coelho,Fabricio Ferreira
Coelho,Rafael Ferreira
Massarollo,Paulo Celso Bosco
Mies,Sérgio
author_role author
author2 Coelho,Rafael Ferreira
Massarollo,Paulo Celso Bosco
Mies,Sérgio
author2_role author
author
author
dc.contributor.author.fl_str_mv Coelho,Fabricio Ferreira
Coelho,Rafael Ferreira
Massarollo,Paulo Celso Bosco
Mies,Sérgio
dc.subject.por.fl_str_mv Liver transplantation
Adverse effects
Immunosuppression
Tacrolimus
Therapeutic use
topic Liver transplantation
Adverse effects
Immunosuppression
Tacrolimus
Therapeutic use
description PURPOSE: To study the indications and results of tacrolimus as rescue therapy for acute cellular or chronic rejection in liver transplantation. PATIENTS AND METHODS: Eighteen liver transplant recipients who underwent rescue therapy with tacrolimus between March 1995 and August 1999 were retrospectively studied. The treatment indication, patients, and graft situation were recorded as of October 31st, 1999. The response to tacrolimus was defined as patient survival with a functional graft and histological reversal of acute cellular, or for chronic rejection, bilirubin serum levels decreasing to up to twice the upper normal limit. RESULTS: Fourteen cases (77.8%) presented a good response. The response rate for the different indications was: (1) acute cellular + sepsis - 0/1 case; (2) recurrent acute cellular - 1/1 case; (3) OKT3-resistant acute cellular - 2/2 cases; (4) steroid-resistant acute cellular + active viral infection - 3/3 cases; (5) chronic rejection - 8/11 cases (72.7% response rate). The 4 patients who did not respond died. CONCLUSION: Tacrolimus rescue therapy was successful in most cases of acute cellular and chronic rejection in liver transplantation.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000300003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000300003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0041-87812003000300003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
dc.source.none.fl_str_mv Revista do Hospital das Clínicas v.58 n.3 2003
reponame:Revista do Hospital das Clínicas
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista do Hospital das Clínicas
collection Revista do Hospital das Clínicas
repository.name.fl_str_mv Revista do Hospital das Clínicas - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||revista.hc@hcnet.usp.br
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