Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids

Detalhes bibliográficos
Autor(a) principal: Precioso,Alexander Roberto
Data de Publicação: 2002
Outros Autores: Proença,Renata Suman Mascaretti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Hospital das Clínicas
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000500009
Resumo: Necrotizing enterocolitis is the most frequently occurring gastrointestinal disorder in premature neonates. Animal models of necrotizing enterocolitis and prenatal administration of cortisone have demonstrated that cortisone may accelerate maturation of the mucosal barrier, therefore reducing the incidence of this gastrointestinal disorder. The authors present a review of the literature of the most important risk factors associated with necrotizing enterocolitis, such as inflammatory gastrointestinal mediators, enteral feeding and bacterial colonization, and immaturity of the gastrointestinal barrier, and we emphasize the necessity for additional studies to explore the prenatal administration of cortisone as a preventive strategy for necrotizing enterocolitis.
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spelling Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroidsNecrotizing enterocolitisNeonatePrematurityCortisone therapyPhysiopathologyNecrotizing enterocolitis is the most frequently occurring gastrointestinal disorder in premature neonates. Animal models of necrotizing enterocolitis and prenatal administration of cortisone have demonstrated that cortisone may accelerate maturation of the mucosal barrier, therefore reducing the incidence of this gastrointestinal disorder. The authors present a review of the literature of the most important risk factors associated with necrotizing enterocolitis, such as inflammatory gastrointestinal mediators, enteral feeding and bacterial colonization, and immaturity of the gastrointestinal barrier, and we emphasize the necessity for additional studies to explore the prenatal administration of cortisone as a preventive strategy for necrotizing enterocolitis.Faculdade de Medicina / Universidade de São Paulo - FM/USP2002-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000500009Revista do Hospital das Clínicas v.57 n.5 2002reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812002000500009info:eu-repo/semantics/openAccessPrecioso,Alexander RobertoProença,Renata Suman Mascarettieng2002-11-13T00:00:00Zoai:scielo:S0041-87812002000500009Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2002-11-13T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
title Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
spellingShingle Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
Precioso,Alexander Roberto
Necrotizing enterocolitis
Neonate
Prematurity
Cortisone therapy
Physiopathology
title_short Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
title_full Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
title_fullStr Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
title_full_unstemmed Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
title_sort Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
author Precioso,Alexander Roberto
author_facet Precioso,Alexander Roberto
Proença,Renata Suman Mascaretti
author_role author
author2 Proença,Renata Suman Mascaretti
author2_role author
dc.contributor.author.fl_str_mv Precioso,Alexander Roberto
Proença,Renata Suman Mascaretti
dc.subject.por.fl_str_mv Necrotizing enterocolitis
Neonate
Prematurity
Cortisone therapy
Physiopathology
topic Necrotizing enterocolitis
Neonate
Prematurity
Cortisone therapy
Physiopathology
description Necrotizing enterocolitis is the most frequently occurring gastrointestinal disorder in premature neonates. Animal models of necrotizing enterocolitis and prenatal administration of cortisone have demonstrated that cortisone may accelerate maturation of the mucosal barrier, therefore reducing the incidence of this gastrointestinal disorder. The authors present a review of the literature of the most important risk factors associated with necrotizing enterocolitis, such as inflammatory gastrointestinal mediators, enteral feeding and bacterial colonization, and immaturity of the gastrointestinal barrier, and we emphasize the necessity for additional studies to explore the prenatal administration of cortisone as a preventive strategy for necrotizing enterocolitis.
publishDate 2002
dc.date.none.fl_str_mv 2002-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000500009
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0041-87812002000500009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
dc.source.none.fl_str_mv Revista do Hospital das Clínicas v.57 n.5 2002
reponame:Revista do Hospital das Clínicas
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
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reponame_str Revista do Hospital das Clínicas
collection Revista do Hospital das Clínicas
repository.name.fl_str_mv Revista do Hospital das Clínicas - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||revista.hc@hcnet.usp.br
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