Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids
Autor(a) principal: | |
---|---|
Data de Publicação: | 2002 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Hospital das Clínicas |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000500009 |
Resumo: | Necrotizing enterocolitis is the most frequently occurring gastrointestinal disorder in premature neonates. Animal models of necrotizing enterocolitis and prenatal administration of cortisone have demonstrated that cortisone may accelerate maturation of the mucosal barrier, therefore reducing the incidence of this gastrointestinal disorder. The authors present a review of the literature of the most important risk factors associated with necrotizing enterocolitis, such as inflammatory gastrointestinal mediators, enteral feeding and bacterial colonization, and immaturity of the gastrointestinal barrier, and we emphasize the necessity for additional studies to explore the prenatal administration of cortisone as a preventive strategy for necrotizing enterocolitis. |
id |
USP-57_7ed943221d6ad6b622928fd71899d52c |
---|---|
oai_identifier_str |
oai:scielo:S0041-87812002000500009 |
network_acronym_str |
USP-57 |
network_name_str |
Revista do Hospital das Clínicas |
repository_id_str |
|
spelling |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroidsNecrotizing enterocolitisNeonatePrematurityCortisone therapyPhysiopathologyNecrotizing enterocolitis is the most frequently occurring gastrointestinal disorder in premature neonates. Animal models of necrotizing enterocolitis and prenatal administration of cortisone have demonstrated that cortisone may accelerate maturation of the mucosal barrier, therefore reducing the incidence of this gastrointestinal disorder. The authors present a review of the literature of the most important risk factors associated with necrotizing enterocolitis, such as inflammatory gastrointestinal mediators, enteral feeding and bacterial colonization, and immaturity of the gastrointestinal barrier, and we emphasize the necessity for additional studies to explore the prenatal administration of cortisone as a preventive strategy for necrotizing enterocolitis.Faculdade de Medicina / Universidade de São Paulo - FM/USP2002-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000500009Revista do Hospital das Clínicas v.57 n.5 2002reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812002000500009info:eu-repo/semantics/openAccessPrecioso,Alexander RobertoProença,Renata Suman Mascarettieng2002-11-13T00:00:00Zoai:scielo:S0041-87812002000500009Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2002-11-13T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids |
title |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids |
spellingShingle |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids Precioso,Alexander Roberto Necrotizing enterocolitis Neonate Prematurity Cortisone therapy Physiopathology |
title_short |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids |
title_full |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids |
title_fullStr |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids |
title_full_unstemmed |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids |
title_sort |
Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids |
author |
Precioso,Alexander Roberto |
author_facet |
Precioso,Alexander Roberto Proença,Renata Suman Mascaretti |
author_role |
author |
author2 |
Proença,Renata Suman Mascaretti |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Precioso,Alexander Roberto Proença,Renata Suman Mascaretti |
dc.subject.por.fl_str_mv |
Necrotizing enterocolitis Neonate Prematurity Cortisone therapy Physiopathology |
topic |
Necrotizing enterocolitis Neonate Prematurity Cortisone therapy Physiopathology |
description |
Necrotizing enterocolitis is the most frequently occurring gastrointestinal disorder in premature neonates. Animal models of necrotizing enterocolitis and prenatal administration of cortisone have demonstrated that cortisone may accelerate maturation of the mucosal barrier, therefore reducing the incidence of this gastrointestinal disorder. The authors present a review of the literature of the most important risk factors associated with necrotizing enterocolitis, such as inflammatory gastrointestinal mediators, enteral feeding and bacterial colonization, and immaturity of the gastrointestinal barrier, and we emphasize the necessity for additional studies to explore the prenatal administration of cortisone as a preventive strategy for necrotizing enterocolitis. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000500009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000500009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0041-87812002000500009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
dc.source.none.fl_str_mv |
Revista do Hospital das Clínicas v.57 n.5 2002 reponame:Revista do Hospital das Clínicas instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista do Hospital das Clínicas |
collection |
Revista do Hospital das Clínicas |
repository.name.fl_str_mv |
Revista do Hospital das Clínicas - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||revista.hc@hcnet.usp.br |
_version_ |
1754820894494031872 |