Age related changes in the elastic fiber system of the interfoveolar ligament
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Hospital das Clínicas |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812000000300003 |
Resumo: | In order to evaluate age related changes of the elastic fiber system in the interfoveolar ligament, we studied the deep inguinal ring from 33 male cadavers aged from stillborn to 76 years. Selective and alternated staining methods for elastic fibers were performed to differentiate oxytalan, elaunin, and mature elastic fibers. We confirmed quantitative changes of the elastic fiber system with aging. There was a significant and progressive reduction of the oxytalan fibers (responsible for tissue resistance) and a significant increment in the mature elastic and elaunin fibers (responsible for tissue elasticity). Furthermore, there were structural changes in the thickness, shortness and curling of these mature elastic fibers. These changes induced loss of the elastic fiber function and loss of the interfoveolar ligament compliance. These factors predispose individuals to the development of indirect inguinal hernias that frequently emerge in adults and aged individuals, especially above the fifth decade. |
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Age related changes in the elastic fiber system of the interfoveolar ligamentElastinInguinal herniaAgingExtracellular matrixTransversalis fasciaIn order to evaluate age related changes of the elastic fiber system in the interfoveolar ligament, we studied the deep inguinal ring from 33 male cadavers aged from stillborn to 76 years. Selective and alternated staining methods for elastic fibers were performed to differentiate oxytalan, elaunin, and mature elastic fibers. We confirmed quantitative changes of the elastic fiber system with aging. There was a significant and progressive reduction of the oxytalan fibers (responsible for tissue resistance) and a significant increment in the mature elastic and elaunin fibers (responsible for tissue elasticity). Furthermore, there were structural changes in the thickness, shortness and curling of these mature elastic fibers. These changes induced loss of the elastic fiber function and loss of the interfoveolar ligament compliance. These factors predispose individuals to the development of indirect inguinal hernias that frequently emerge in adults and aged individuals, especially above the fifth decade.Faculdade de Medicina / Universidade de São Paulo - FM/USP2000-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812000000300003Revista do Hospital das Clínicas v.55 n.3 2000reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812000000300003info:eu-repo/semantics/openAccessQuintas,Mario LuizRodrigues,Consuelo JunqueiraJin,Hwan YooRodrigues Junior,Aldo Junqueiraeng2000-09-06T00:00:00Zoai:scielo:S0041-87812000000300003Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2000-09-06T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Age related changes in the elastic fiber system of the interfoveolar ligament |
title |
Age related changes in the elastic fiber system of the interfoveolar ligament |
spellingShingle |
Age related changes in the elastic fiber system of the interfoveolar ligament Quintas,Mario Luiz Elastin Inguinal hernia Aging Extracellular matrix Transversalis fascia |
title_short |
Age related changes in the elastic fiber system of the interfoveolar ligament |
title_full |
Age related changes in the elastic fiber system of the interfoveolar ligament |
title_fullStr |
Age related changes in the elastic fiber system of the interfoveolar ligament |
title_full_unstemmed |
Age related changes in the elastic fiber system of the interfoveolar ligament |
title_sort |
Age related changes in the elastic fiber system of the interfoveolar ligament |
author |
Quintas,Mario Luiz |
author_facet |
Quintas,Mario Luiz Rodrigues,Consuelo Junqueira Jin,Hwan Yoo Rodrigues Junior,Aldo Junqueira |
author_role |
author |
author2 |
Rodrigues,Consuelo Junqueira Jin,Hwan Yoo Rodrigues Junior,Aldo Junqueira |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Quintas,Mario Luiz Rodrigues,Consuelo Junqueira Jin,Hwan Yoo Rodrigues Junior,Aldo Junqueira |
dc.subject.por.fl_str_mv |
Elastin Inguinal hernia Aging Extracellular matrix Transversalis fascia |
topic |
Elastin Inguinal hernia Aging Extracellular matrix Transversalis fascia |
description |
In order to evaluate age related changes of the elastic fiber system in the interfoveolar ligament, we studied the deep inguinal ring from 33 male cadavers aged from stillborn to 76 years. Selective and alternated staining methods for elastic fibers were performed to differentiate oxytalan, elaunin, and mature elastic fibers. We confirmed quantitative changes of the elastic fiber system with aging. There was a significant and progressive reduction of the oxytalan fibers (responsible for tissue resistance) and a significant increment in the mature elastic and elaunin fibers (responsible for tissue elasticity). Furthermore, there were structural changes in the thickness, shortness and curling of these mature elastic fibers. These changes induced loss of the elastic fiber function and loss of the interfoveolar ligament compliance. These factors predispose individuals to the development of indirect inguinal hernias that frequently emerge in adults and aged individuals, especially above the fifth decade. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812000000300003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812000000300003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0041-87812000000300003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
dc.source.none.fl_str_mv |
Revista do Hospital das Clínicas v.55 n.3 2000 reponame:Revista do Hospital das Clínicas instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista do Hospital das Clínicas |
collection |
Revista do Hospital das Clínicas |
repository.name.fl_str_mv |
Revista do Hospital das Clínicas - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||revista.hc@hcnet.usp.br |
_version_ |
1754820894036852736 |