Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency

Detalhes bibliográficos
Autor(a) principal: Costa,Elaine Maria Frade
Data de Publicação: 2001
Outros Autores: Arnhold,Ivo Jorge Prado, Inacio,Marlene, Mendonca,Berenice Bilharinho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Hospital das Clínicas
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812001000500002
Resumo: Bone is an androgen-dependent tissue, but it is not clear whether the androgen action in bone depends on testosterone or on dihydrotestosterone. Patients with 5alpha-reductase 2 deficiency present normal levels of testosterone and low levels of dihydrotestosterone, providing an in vivo human model for the analysis of the effect of testosterone on bone. OBJECTIVE: To analyze bone mineral density in 4 adult patients with male pseudohermaphroditism due to 5alpha-reductase 2 deficiency. RESULTS: Three patients presented normal bone mineral density of the lumbar column (L1-L4) and femur neck, and the other patient presented a slight osteopenia in the lumbar column. CONCLUSION: Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.
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spelling Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiencyBone mineral densityMale pseudohermaphroditism5alpha-reductase type 2 deficiencyBone is an androgen-dependent tissue, but it is not clear whether the androgen action in bone depends on testosterone or on dihydrotestosterone. Patients with 5alpha-reductase 2 deficiency present normal levels of testosterone and low levels of dihydrotestosterone, providing an in vivo human model for the analysis of the effect of testosterone on bone. OBJECTIVE: To analyze bone mineral density in 4 adult patients with male pseudohermaphroditism due to 5alpha-reductase 2 deficiency. RESULTS: Three patients presented normal bone mineral density of the lumbar column (L1-L4) and femur neck, and the other patient presented a slight osteopenia in the lumbar column. CONCLUSION: Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.Faculdade de Medicina / Universidade de São Paulo - FM/USP2001-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812001000500002Revista do Hospital das Clínicas v.56 n.5 2001reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812001000500002info:eu-repo/semantics/openAccessCosta,Elaine Maria FradeArnhold,Ivo Jorge PradoInacio,MarleneMendonca,Berenice Bilharinhoeng2001-12-21T00:00:00Zoai:scielo:S0041-87812001000500002Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2001-12-21T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
title Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
spellingShingle Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
Costa,Elaine Maria Frade
Bone mineral density
Male pseudohermaphroditism
5alpha-reductase type 2 deficiency
title_short Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
title_full Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
title_fullStr Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
title_full_unstemmed Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
title_sort Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
author Costa,Elaine Maria Frade
author_facet Costa,Elaine Maria Frade
Arnhold,Ivo Jorge Prado
Inacio,Marlene
Mendonca,Berenice Bilharinho
author_role author
author2 Arnhold,Ivo Jorge Prado
Inacio,Marlene
Mendonca,Berenice Bilharinho
author2_role author
author
author
dc.contributor.author.fl_str_mv Costa,Elaine Maria Frade
Arnhold,Ivo Jorge Prado
Inacio,Marlene
Mendonca,Berenice Bilharinho
dc.subject.por.fl_str_mv Bone mineral density
Male pseudohermaphroditism
5alpha-reductase type 2 deficiency
topic Bone mineral density
Male pseudohermaphroditism
5alpha-reductase type 2 deficiency
description Bone is an androgen-dependent tissue, but it is not clear whether the androgen action in bone depends on testosterone or on dihydrotestosterone. Patients with 5alpha-reductase 2 deficiency present normal levels of testosterone and low levels of dihydrotestosterone, providing an in vivo human model for the analysis of the effect of testosterone on bone. OBJECTIVE: To analyze bone mineral density in 4 adult patients with male pseudohermaphroditism due to 5alpha-reductase 2 deficiency. RESULTS: Three patients presented normal bone mineral density of the lumbar column (L1-L4) and femur neck, and the other patient presented a slight osteopenia in the lumbar column. CONCLUSION: Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.
publishDate 2001
dc.date.none.fl_str_mv 2001-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812001000500002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812001000500002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0041-87812001000500002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
dc.source.none.fl_str_mv Revista do Hospital das Clínicas v.56 n.5 2001
reponame:Revista do Hospital das Clínicas
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista do Hospital das Clínicas
collection Revista do Hospital das Clínicas
repository.name.fl_str_mv Revista do Hospital das Clínicas - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||revista.hc@hcnet.usp.br
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