Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Archives of Clinical Psychiatry |
DOI: | 10.1590/0101-60830000000184 |
Texto Completo: | https://www.revistas.usp.br/acp/article/view/162158 |
Resumo: | Objective: Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods: Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion: MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion: Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression. |
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Archives of Clinical Psychiatry |
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Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatmentMean platelet volumeneutrophil to lymphocyte ratiodepressiontreatmentinflammationObjective: Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods: Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion: MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion: Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression.Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria2019-09-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/acp/article/view/16215810.1590/0101-60830000000184Archives of Clinical Psychiatry; v. 46 n. 1 (2019); 9-13Archives of Clinical Psychiatry; Vol. 46 No. 1 (2019); 9-13Revista de Psiquiatria Clínica; Vol. 46 Núm. 1 (2019); 9-131806-938X0101-6083reponame:Archives of Clinical Psychiatryinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/acp/article/view/162158/155995Öztürk, AhmetŞahan, EbruMirçik, Ali BarlasDeveci, ErdemYilmaz, OnurKirpinar, İsmetinfo:eu-repo/semantics/openAccess2019-09-11T16:15:19Zoai:revistas.usp.br:article/162158Revistahttp://www.hcnet.usp.br/ipq/revista/index.htmlPUBhttps://old.scielo.br/oai/scielo-oai.php||archives@usp.br1806-938X0101-6083opendoar:2019-09-11T16:15:19Archives of Clinical Psychiatry - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment |
title |
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment |
spellingShingle |
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment Öztürk, Ahmet Mean platelet volume neutrophil to lymphocyte ratio depression treatment inflammation Öztürk, Ahmet Mean platelet volume neutrophil to lymphocyte ratio depression treatment inflammation |
title_short |
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment |
title_full |
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment |
title_fullStr |
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment |
title_full_unstemmed |
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment |
title_sort |
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment |
author |
Öztürk, Ahmet |
author_facet |
Öztürk, Ahmet Öztürk, Ahmet Şahan, Ebru Mirçik, Ali Barlas Deveci, Erdem Yilmaz, Onur Kirpinar, İsmet Şahan, Ebru Mirçik, Ali Barlas Deveci, Erdem Yilmaz, Onur Kirpinar, İsmet |
author_role |
author |
author2 |
Şahan, Ebru Mirçik, Ali Barlas Deveci, Erdem Yilmaz, Onur Kirpinar, İsmet |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Öztürk, Ahmet Şahan, Ebru Mirçik, Ali Barlas Deveci, Erdem Yilmaz, Onur Kirpinar, İsmet |
dc.subject.por.fl_str_mv |
Mean platelet volume neutrophil to lymphocyte ratio depression treatment inflammation |
topic |
Mean platelet volume neutrophil to lymphocyte ratio depression treatment inflammation |
description |
Objective: Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods: Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion: MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion: Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-11 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/acp/article/view/162158 10.1590/0101-60830000000184 |
url |
https://www.revistas.usp.br/acp/article/view/162158 |
identifier_str_mv |
10.1590/0101-60830000000184 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/acp/article/view/162158/155995 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria |
dc.source.none.fl_str_mv |
Archives of Clinical Psychiatry; v. 46 n. 1 (2019); 9-13 Archives of Clinical Psychiatry; Vol. 46 No. 1 (2019); 9-13 Revista de Psiquiatria Clínica; Vol. 46 Núm. 1 (2019); 9-13 1806-938X 0101-6083 reponame:Archives of Clinical Psychiatry instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Archives of Clinical Psychiatry |
collection |
Archives of Clinical Psychiatry |
repository.name.fl_str_mv |
Archives of Clinical Psychiatry - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||archives@usp.br |
_version_ |
1822183930831306752 |
dc.identifier.doi.none.fl_str_mv |
10.1590/0101-60830000000184 |