Toxoplasma gondii infection and chronic schizophrenia: is there any association?

Detalhes bibliográficos
Autor(a) principal: Campos-Carli, Salvina Maria de
Data de Publicação: 2017
Outros Autores: Vieira, Érica Leandro Marciano, Rocha, Natalia Pessoa, Oliveira, Keliane de, Guimarães, Fernanda Carneiro, Barbosa, Izabela Guimarães, Barros, João Luís Vieira Monteiro de, Okusaga, Olaoluwa, Martins-Filho, Olindo Assis, Salgado, João Vinícius, Teixeira, Antônio Lúcio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Archives of Clinical Psychiatry
Texto Completo: https://www.revistas.usp.br/acp/article/view/144874
Resumo: Background: Toxoplasma gondii (T. gondii) infection has been identified as a risk factor for schizophrenia. Objectives: Herein, we sought to evaluate the association between T. gondii infection and clinical symptoms and quality of life in patients with schizophrenia. Methods: We conducted a cross-sectional study with 48 patients with chronic schizophrenia and 40 controls. Peripheral blood was drawn, and IgM and IgG anti-T. gondii antibodies were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). Depressive, positive and negative symptoms were assessed, respectively, by the Calgary Depression Scale (CDS) and the Positive and Negative Syndrome Scale (PANSS). Cognitive performance was assessed in patients by the Brazilian version of the Schizophrenia Cognition Rating Scale (SCoRS-BR). Quality of life was assessed by the Brazilian version of the Quality of Life in Schizophrenia scale (QLS-BR). Results: The prevalence and titers of T. gondii IgM and IgG antibodies did not differ between patients and controls. The positive serology for T. gondii IgG antibodies was not associated with illness symptoms, cognitive performance, depressive symptoms or quality of life. Discussion: Our findings suggest that toxoplasmosis infection is not associated with severity of symptoms, quality of life, cognitive or depressive symptoms in schizophrenia patients.
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spelling Toxoplasma gondii infection and chronic schizophrenia: is there any association?Toxoplasma gondiischizophreniacognitiondepressionquality of life Background: Toxoplasma gondii (T. gondii) infection has been identified as a risk factor for schizophrenia. Objectives: Herein, we sought to evaluate the association between T. gondii infection and clinical symptoms and quality of life in patients with schizophrenia. Methods: We conducted a cross-sectional study with 48 patients with chronic schizophrenia and 40 controls. Peripheral blood was drawn, and IgM and IgG anti-T. gondii antibodies were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). Depressive, positive and negative symptoms were assessed, respectively, by the Calgary Depression Scale (CDS) and the Positive and Negative Syndrome Scale (PANSS). Cognitive performance was assessed in patients by the Brazilian version of the Schizophrenia Cognition Rating Scale (SCoRS-BR). Quality of life was assessed by the Brazilian version of the Quality of Life in Schizophrenia scale (QLS-BR). Results: The prevalence and titers of T. gondii IgM and IgG antibodies did not differ between patients and controls. The positive serology for T. gondii IgG antibodies was not associated with illness symptoms, cognitive performance, depressive symptoms or quality of life. Discussion: Our findings suggest that toxoplasmosis infection is not associated with severity of symptoms, quality of life, cognitive or depressive symptoms in schizophrenia patients.Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/acp/article/view/14487410.1590/0101-60830000000140Archives of Clinical Psychiatry; v. 44 n. 6 (2017); 145-148Archives of Clinical Psychiatry; Vol. 44 No. 6 (2017); 145-148Revista de Psiquiatria Clínica; Vol. 44 Núm. 6 (2017); 145-1481806-938X0101-6083reponame:Archives of Clinical Psychiatryinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/acp/article/view/144874/139101Copyright (c) 2018 Archives of Clinical Psychiatryinfo:eu-repo/semantics/openAccessCampos-Carli, Salvina Maria deVieira, Érica Leandro MarcianoRocha, Natalia PessoaOliveira, Keliane deGuimarães, Fernanda CarneiroBarbosa, Izabela GuimarãesBarros, João Luís Vieira Monteiro deOkusaga, OlaoluwaMartins-Filho, Olindo AssisSalgado, João ViníciusTeixeira, Antônio Lúcio2018-03-29T16:27:27Zoai:revistas.usp.br:article/144874Revistahttp://www.hcnet.usp.br/ipq/revista/index.htmlPUBhttps://old.scielo.br/oai/scielo-oai.php||archives@usp.br1806-938X0101-6083opendoar:2018-03-29T16:27:27Archives of Clinical Psychiatry - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Toxoplasma gondii infection and chronic schizophrenia: is there any association?
title Toxoplasma gondii infection and chronic schizophrenia: is there any association?
spellingShingle Toxoplasma gondii infection and chronic schizophrenia: is there any association?
Campos-Carli, Salvina Maria de
Toxoplasma gondii
schizophrenia
cognition
depression
quality of life
title_short Toxoplasma gondii infection and chronic schizophrenia: is there any association?
title_full Toxoplasma gondii infection and chronic schizophrenia: is there any association?
title_fullStr Toxoplasma gondii infection and chronic schizophrenia: is there any association?
title_full_unstemmed Toxoplasma gondii infection and chronic schizophrenia: is there any association?
title_sort Toxoplasma gondii infection and chronic schizophrenia: is there any association?
author Campos-Carli, Salvina Maria de
author_facet Campos-Carli, Salvina Maria de
Vieira, Érica Leandro Marciano
Rocha, Natalia Pessoa
Oliveira, Keliane de
Guimarães, Fernanda Carneiro
Barbosa, Izabela Guimarães
Barros, João Luís Vieira Monteiro de
Okusaga, Olaoluwa
Martins-Filho, Olindo Assis
Salgado, João Vinícius
Teixeira, Antônio Lúcio
author_role author
author2 Vieira, Érica Leandro Marciano
Rocha, Natalia Pessoa
Oliveira, Keliane de
Guimarães, Fernanda Carneiro
Barbosa, Izabela Guimarães
Barros, João Luís Vieira Monteiro de
Okusaga, Olaoluwa
Martins-Filho, Olindo Assis
Salgado, João Vinícius
Teixeira, Antônio Lúcio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Campos-Carli, Salvina Maria de
Vieira, Érica Leandro Marciano
Rocha, Natalia Pessoa
Oliveira, Keliane de
Guimarães, Fernanda Carneiro
Barbosa, Izabela Guimarães
Barros, João Luís Vieira Monteiro de
Okusaga, Olaoluwa
Martins-Filho, Olindo Assis
Salgado, João Vinícius
Teixeira, Antônio Lúcio
dc.subject.por.fl_str_mv Toxoplasma gondii
schizophrenia
cognition
depression
quality of life
topic Toxoplasma gondii
schizophrenia
cognition
depression
quality of life
description Background: Toxoplasma gondii (T. gondii) infection has been identified as a risk factor for schizophrenia. Objectives: Herein, we sought to evaluate the association between T. gondii infection and clinical symptoms and quality of life in patients with schizophrenia. Methods: We conducted a cross-sectional study with 48 patients with chronic schizophrenia and 40 controls. Peripheral blood was drawn, and IgM and IgG anti-T. gondii antibodies were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). Depressive, positive and negative symptoms were assessed, respectively, by the Calgary Depression Scale (CDS) and the Positive and Negative Syndrome Scale (PANSS). Cognitive performance was assessed in patients by the Brazilian version of the Schizophrenia Cognition Rating Scale (SCoRS-BR). Quality of life was assessed by the Brazilian version of the Quality of Life in Schizophrenia scale (QLS-BR). Results: The prevalence and titers of T. gondii IgM and IgG antibodies did not differ between patients and controls. The positive serology for T. gondii IgG antibodies was not associated with illness symptoms, cognitive performance, depressive symptoms or quality of life. Discussion: Our findings suggest that toxoplasmosis infection is not associated with severity of symptoms, quality of life, cognitive or depressive symptoms in schizophrenia patients.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/acp/article/view/144874
10.1590/0101-60830000000140
url https://www.revistas.usp.br/acp/article/view/144874
identifier_str_mv 10.1590/0101-60830000000140
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/acp/article/view/144874/139101
dc.rights.driver.fl_str_mv Copyright (c) 2018 Archives of Clinical Psychiatry
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Archives of Clinical Psychiatry
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
dc.source.none.fl_str_mv Archives of Clinical Psychiatry; v. 44 n. 6 (2017); 145-148
Archives of Clinical Psychiatry; Vol. 44 No. 6 (2017); 145-148
Revista de Psiquiatria Clínica; Vol. 44 Núm. 6 (2017); 145-148
1806-938X
0101-6083
reponame:Archives of Clinical Psychiatry
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Archives of Clinical Psychiatry
collection Archives of Clinical Psychiatry
repository.name.fl_str_mv Archives of Clinical Psychiatry - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||archives@usp.br
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