Nifedipine decreases bone quality in female rats with osteopenia

Detalhes bibliográficos
Autor(a) principal: Bertoncello, Dernival
Data de Publicação: 2008
Outros Autores: Silva, Andrezza Ferreira da, Borges, Juliana Almeida de Souza
Tipo de documento: Artigo
Idioma: por
Título da fonte: Fisioterapia e Pesquisa
Texto Completo: https://www.revistas.usp.br/fpusp/article/view/12090
Resumo: The aim of this study was to assess, by biomechanical and physical parameters, the bone quality of femurs from ovariectomized female rats treated with nifedipine. Twenty eight Wistar female rats, 4 months old, were divided into four groups: intact (Int); intact treated with nifedipine (Int+Nfd); ovariectomized treated with saline (Ovx+Sal); ovariectomized treated with nifedipine (Ovx+Nfd). Treatment was carried out for eight weeks, six days per week, with administration of 10 mg of nifedipine or 0.1/100g BW of saline, by gavage. After removing the right femur of each animal, maximum load support, mineral density, and bone quality were assessed. Results were statistically analysed and significance level set at p
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spelling Nifedipine decreases bone quality in female rats with osteopenia Nifedipina promove diminuição da qualidade óssea em ratas com osteopenia Densidade ósseaDoenças ósseas metabólicasNifedipinaRatosBone densityBone diseasesmetabolicNifedipineRats The aim of this study was to assess, by biomechanical and physical parameters, the bone quality of femurs from ovariectomized female rats treated with nifedipine. Twenty eight Wistar female rats, 4 months old, were divided into four groups: intact (Int); intact treated with nifedipine (Int+Nfd); ovariectomized treated with saline (Ovx+Sal); ovariectomized treated with nifedipine (Ovx+Nfd). Treatment was carried out for eight weeks, six days per week, with administration of 10 mg of nifedipine or 0.1/100g BW of saline, by gavage. After removing the right femur of each animal, maximum load support, mineral density, and bone quality were assessed. Results were statistically analysed and significance level set at p O objetivo do trabalho foi avaliar, por parâmetros biomecânicos e físicos, a qualidade óssea dos fêmures de ratas ovariectomizadas tratadas com nifedipina. Foram utilizadas 28 ratas Wistar, de 4 meses de idade, divididas nos grupos: intactas (Int); ovariectomizadas tratadas com salina (Ovx+Sal); ovariectomizadas tratadas com nifedipina (Ovx+Nfd), intactas tratadas com nifedipina (Int+Nfd). O tratamento durou oito semanas, seis dias por semana, com administração de nifedipina ou salina, por gavage, na dose de 10 mg e 0,1g/100g PC respectivamente. Tendo-se retirado o fêmur direito de cada animal, verificou-se a carga máxima suportada, a densidade mineral e a qualidade óssea. Os resultados foram analisados estatisticamente, com nível de significância fixado em pUniversidade de São Paulo. Faculdade de Medicina2008-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/fpusp/article/view/1209010.1590/S1809-29502008000400007Fisioterapia e Pesquisa; Vol. 15 No. 4 (2008); 355-360 Fisioterapia e Pesquisa; Vol. 15 Núm. 4 (2008); 355-360 Fisioterapia e Pesquisa; v. 15 n. 4 (2008); 355-360 2316-91171809-2950reponame:Fisioterapia e Pesquisainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/fpusp/article/view/12090/13867Copyright (c) 2017 Fisioterapia e Pesquisainfo:eu-repo/semantics/openAccessBertoncello, DernivalSilva, Andrezza Ferreira daBorges, Juliana Almeida de Souza2012-05-13T15:56:02Zoai:revistas.usp.br:article/12090Revistahttp://www.revistas.usp.br/fpuspPUBhttps://www.revistas.usp.br/fpusp/oai||revfisio@usp.br2316-91171809-2950opendoar:2012-05-13T15:56:02Fisioterapia e Pesquisa - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Nifedipine decreases bone quality in female rats with osteopenia
Nifedipina promove diminuição da qualidade óssea em ratas com osteopenia
title Nifedipine decreases bone quality in female rats with osteopenia
spellingShingle Nifedipine decreases bone quality in female rats with osteopenia
Bertoncello, Dernival
Densidade óssea
Doenças ósseas metabólicas
Nifedipina
Ratos
Bone density
Bone diseases
metabolic
Nifedipine
Rats
title_short Nifedipine decreases bone quality in female rats with osteopenia
title_full Nifedipine decreases bone quality in female rats with osteopenia
title_fullStr Nifedipine decreases bone quality in female rats with osteopenia
title_full_unstemmed Nifedipine decreases bone quality in female rats with osteopenia
title_sort Nifedipine decreases bone quality in female rats with osteopenia
author Bertoncello, Dernival
author_facet Bertoncello, Dernival
Silva, Andrezza Ferreira da
Borges, Juliana Almeida de Souza
author_role author
author2 Silva, Andrezza Ferreira da
Borges, Juliana Almeida de Souza
author2_role author
author
dc.contributor.author.fl_str_mv Bertoncello, Dernival
Silva, Andrezza Ferreira da
Borges, Juliana Almeida de Souza
dc.subject.por.fl_str_mv Densidade óssea
Doenças ósseas metabólicas
Nifedipina
Ratos
Bone density
Bone diseases
metabolic
Nifedipine
Rats
topic Densidade óssea
Doenças ósseas metabólicas
Nifedipina
Ratos
Bone density
Bone diseases
metabolic
Nifedipine
Rats
description The aim of this study was to assess, by biomechanical and physical parameters, the bone quality of femurs from ovariectomized female rats treated with nifedipine. Twenty eight Wistar female rats, 4 months old, were divided into four groups: intact (Int); intact treated with nifedipine (Int+Nfd); ovariectomized treated with saline (Ovx+Sal); ovariectomized treated with nifedipine (Ovx+Nfd). Treatment was carried out for eight weeks, six days per week, with administration of 10 mg of nifedipine or 0.1/100g BW of saline, by gavage. After removing the right femur of each animal, maximum load support, mineral density, and bone quality were assessed. Results were statistically analysed and significance level set at p
publishDate 2008
dc.date.none.fl_str_mv 2008-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/fpusp/article/view/12090
10.1590/S1809-29502008000400007
url https://www.revistas.usp.br/fpusp/article/view/12090
identifier_str_mv 10.1590/S1809-29502008000400007
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/fpusp/article/view/12090/13867
dc.rights.driver.fl_str_mv Copyright (c) 2017 Fisioterapia e Pesquisa
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Fisioterapia e Pesquisa
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina
dc.source.none.fl_str_mv Fisioterapia e Pesquisa; Vol. 15 No. 4 (2008); 355-360
Fisioterapia e Pesquisa; Vol. 15 Núm. 4 (2008); 355-360
Fisioterapia e Pesquisa; v. 15 n. 4 (2008); 355-360
2316-9117
1809-2950
reponame:Fisioterapia e Pesquisa
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Fisioterapia e Pesquisa
collection Fisioterapia e Pesquisa
repository.name.fl_str_mv Fisioterapia e Pesquisa - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||revfisio@usp.br
_version_ 1787713733502435328

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