Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats

Detalhes bibliográficos
Autor(a) principal: Santos Júnior, Francisco Fleury Uchoa
Data de Publicação: 2017
Outros Autores: Souza, Karla Camila Lima de, Serra, Daniel Silveira, Ceccatto, Vânia Marilande, Cavalcante, Francisco Sales Ávila
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Fisioterapia e Pesquisa
Texto Completo: https://www.revistas.usp.br/fpusp/article/view/134654
Resumo: Immobilization is a condition that affects several segments and organic systems, including the respiratory system, leading to structural and functional alterations. The purpose of this study was to analyze pulmonary function and micromechanical structure after 14 days of movement restriction in rats. Fourteen female Wistar rats with body mass between 210±50 g were used, divided into two groups, composed of (n=7) each group: Control (C) and Immobilized (I). The immobilization procedure involved the abdomen (and last ribs), pelvis, hip and knee extension and the ankle in plantar flexion in the two week period. After the immobilization period, an analysis of the pulmonary function was performed using a mechanical ventilator for small animals, flexVent, and alveolar recruitment maneuvers. Subsequently, lung strips were removed from each animal for pulmonary micromechanics analysis. Statistical analysis was performed using the unpaired t test with p
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spelling Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female ratsAnálise da função pulmonar e estrutura micromecânica após 14 dias de restrição de movimento em ratasAnálisis de la función pulmonar y estructura micromecanica después de 14 días de restricción en el movimiento en ratasImobilizaçãoSistema RespiratórioPulmãoInmobilizaciónSistema RespiratorioPulmónImmobilizationRespiratory SystemLung Immobilization is a condition that affects several segments and organic systems, including the respiratory system, leading to structural and functional alterations. The purpose of this study was to analyze pulmonary function and micromechanical structure after 14 days of movement restriction in rats. Fourteen female Wistar rats with body mass between 210±50 g were used, divided into two groups, composed of (n=7) each group: Control (C) and Immobilized (I). The immobilization procedure involved the abdomen (and last ribs), pelvis, hip and knee extension and the ankle in plantar flexion in the two week period. After the immobilization period, an analysis of the pulmonary function was performed using a mechanical ventilator for small animals, flexVent, and alveolar recruitment maneuvers. Subsequently, lung strips were removed from each animal for pulmonary micromechanics analysis. Statistical analysis was performed using the unpaired t test with p La inmobilización es una condición que compromete diversos segmentos y sistemas orgánicos incluso el sistema respiratorio, llevando a alteraciones estructurales y funcionales. El objectivo de este estudio fue analizar la función pulmonar y estructura micromecánica después de 14 días de restricción en el movimiento de ratas. Fueron utilizados catorce ratas Wistar con masa corporal entre 210 g±50 g, distribuidas en dos grupos, compuestos por (n=7) cada grupo: Control (C) y Inmobilizado (I). El procedimiento de inmobilización envolvió el abdomen (y últimas costillas), la pelvis, la cadera y la rodilla en extensión y el tobillo en flexión plantar el periodo de dos semanas. Después del periodo de inmobilización fue realizado el análisis de la función pulmonar por medio del ventilador mecánico para pequeños animales flexVent y manobras de recrutamiento alveolar (MR). Posteriormente, fueron retirados pedazos del pulmón de cada animal para análisis de la micromecánica pulmonar. Para el análisis estadística se utilizó la prueba t no pareada con significación estadística (p A imobilização é uma condição que compromete diversos segmentos e sistemas orgânicos, inclusive o sistema respiratório, levando a alterações estruturais e funcionais. O objetivo deste estudo foi analisar a função pulmonar e estrutura micromecânica após 14 dias de restrição de movimento de ratas. Foram utilizados catorze ratas Wistar com massa corporal entre 210 g±50 g, distribuídas em dois grupos, compostos por (n=7) cada grupo: Controle (C) e Imobilizado (I). O procedimento de imobilização envolveu abdômen (e últimas costelas), pelve, quadril e joelho em extensão, além de tornozelo em flexão plantar, por duas semanas. Após esse período de imobilização, foi realizada a análise da função pulmonar por ventilador mecânico para pequenos animais (flexiVent) e manobras de recrutamento alveolar (MR). E, posteriormente, foram retiradas tiras do pulmão de cada animal para analisar a micromecânica pulmonar. Para a análise estatística, utilizou-se o teste t não pareado com significância estatística (pUniversidade de São Paulo. Faculdade de Medicina2017-07-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://www.revistas.usp.br/fpusp/article/view/13465410.1590/1809-2950/17484624022017Fisioterapia e Pesquisa; Vol. 24 No. 2 (2017); 205-210Fisioterapia e Pesquisa; Vol. 24 Núm. 2 (2017); 205-210Fisioterapia e Pesquisa; v. 24 n. 2 (2017); 205-2102316-91171809-2950reponame:Fisioterapia e Pesquisainstname:Universidade de São Paulo (USP)instacron:USPporenghttps://www.revistas.usp.br/fpusp/article/view/134654/130456https://www.revistas.usp.br/fpusp/article/view/134654/130457Copyright (c) 2017 Fisioterapia e Pesquisahttps://creativecommons.org/licenses/by-sa/4.0info:eu-repo/semantics/openAccessSantos Júnior, Francisco Fleury UchoaSouza, Karla Camila Lima deSerra, Daniel SilveiraCeccatto, Vânia MarilandeCavalcante, Francisco Sales Ávila2023-05-26T14:14:59Zoai:revistas.usp.br:article/134654Revistahttp://www.revistas.usp.br/fpuspPUBhttps://www.revistas.usp.br/fpusp/oai||revfisio@usp.br2316-91171809-2950opendoar:2023-05-26T14:14:59Fisioterapia e Pesquisa - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats
Análise da função pulmonar e estrutura micromecânica após 14 dias de restrição de movimento em ratas
Análisis de la función pulmonar y estructura micromecanica después de 14 días de restricción en el movimiento en ratas
title Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats
spellingShingle Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats
Santos Júnior, Francisco Fleury Uchoa
Imobilização
Sistema Respiratório
Pulmão
Inmobilización
Sistema Respiratorio
Pulmón
Immobilization
Respiratory System
Lung
title_short Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats
title_full Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats
title_fullStr Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats
title_full_unstemmed Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats
title_sort Analysis of pulmonary function and micromechanics structure after 14 days of movement restriction in female rats
author Santos Júnior, Francisco Fleury Uchoa
author_facet Santos Júnior, Francisco Fleury Uchoa
Souza, Karla Camila Lima de
Serra, Daniel Silveira
Ceccatto, Vânia Marilande
Cavalcante, Francisco Sales Ávila
author_role author
author2 Souza, Karla Camila Lima de
Serra, Daniel Silveira
Ceccatto, Vânia Marilande
Cavalcante, Francisco Sales Ávila
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos Júnior, Francisco Fleury Uchoa
Souza, Karla Camila Lima de
Serra, Daniel Silveira
Ceccatto, Vânia Marilande
Cavalcante, Francisco Sales Ávila
dc.subject.por.fl_str_mv Imobilização
Sistema Respiratório
Pulmão
Inmobilización
Sistema Respiratorio
Pulmón
Immobilization
Respiratory System
Lung
topic Imobilização
Sistema Respiratório
Pulmão
Inmobilización
Sistema Respiratorio
Pulmón
Immobilization
Respiratory System
Lung
description Immobilization is a condition that affects several segments and organic systems, including the respiratory system, leading to structural and functional alterations. The purpose of this study was to analyze pulmonary function and micromechanical structure after 14 days of movement restriction in rats. Fourteen female Wistar rats with body mass between 210±50 g were used, divided into two groups, composed of (n=7) each group: Control (C) and Immobilized (I). The immobilization procedure involved the abdomen (and last ribs), pelvis, hip and knee extension and the ankle in plantar flexion in the two week period. After the immobilization period, an analysis of the pulmonary function was performed using a mechanical ventilator for small animals, flexVent, and alveolar recruitment maneuvers. Subsequently, lung strips were removed from each animal for pulmonary micromechanics analysis. Statistical analysis was performed using the unpaired t test with p
publishDate 2017
dc.date.none.fl_str_mv 2017-07-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/fpusp/article/view/134654
10.1590/1809-2950/17484624022017
url https://www.revistas.usp.br/fpusp/article/view/134654
identifier_str_mv 10.1590/1809-2950/17484624022017
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/fpusp/article/view/134654/130456
https://www.revistas.usp.br/fpusp/article/view/134654/130457
dc.rights.driver.fl_str_mv Copyright (c) 2017 Fisioterapia e Pesquisa
https://creativecommons.org/licenses/by-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Fisioterapia e Pesquisa
https://creativecommons.org/licenses/by-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina
dc.source.none.fl_str_mv Fisioterapia e Pesquisa; Vol. 24 No. 2 (2017); 205-210
Fisioterapia e Pesquisa; Vol. 24 Núm. 2 (2017); 205-210
Fisioterapia e Pesquisa; v. 24 n. 2 (2017); 205-210
2316-9117
1809-2950
reponame:Fisioterapia e Pesquisa
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Fisioterapia e Pesquisa
collection Fisioterapia e Pesquisa
repository.name.fl_str_mv Fisioterapia e Pesquisa - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||revfisio@usp.br
_version_ 1787713739048353792

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