Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain

Detalhes bibliográficos
Autor(a) principal: Alaiti, Rafael Krasic
Data de Publicação: 2021
Tipo de documento: Tese
Idioma: eng
Título da fonte: Biblioteca Digital de Teses e Dissertações da USP
Texto Completo: https://www.teses.usp.br/teses/disponiveis/47/47135/tde-01102021-162436/
Resumo: Although our understanding about pain neurobiology have increased over the last decades, there is still a gap of knowledge regarding the understanding of the mechanisms associated with pain persistence and the mechanisms of action of interventions for subjects with chronic musculoskeletal pain. The main focus of this thesis was to discuss in depth the possible underlying mechanisms associated with pain persistence and recovery in an effort to contribute to the bridging of this gap of knowledge throught four researchs. The first three studies investigated assumptions of current hypothesis about pain persistence through the lens of learning theories, by verifyng if (1) pain can be conditioned to movements through associative learning; (2) investigating which factors were associated with pain distribution through movements and daily activities commonly reported as painful by subjects with chronic pain; and by (3) investigating if chronic musculoskeletal pain is associated with perceptual distortions in other perceptual continuums associated with movements that could foster avoidance behaviors. The last study of this thesis was (4) a systematic review that aimed to systematically identify and synthesise studies that conducted mediation analyses of randomized controlled trials that test or estimate indirect effects of cognitive-behavioral and exercise-based interventions for pain and disability in people with chronic musculoskeletal pain. The basis for the conduction of these studies, as well as its main findings were discussed throughout this thesis
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spelling Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal painA dor relacionada ao movimento como uma resposta aprendida: uma investigação dos possíveis mecanismos subjacentes à persistência e melhora da dor relacionada ao movimento em indivíduos com quadros de dor musculoesquelética crônicaAprendizagemBehaviorChronic painComportamentoDorDor crônicaLearningMecanismos de açãoMechanisms of actionPainAlthough our understanding about pain neurobiology have increased over the last decades, there is still a gap of knowledge regarding the understanding of the mechanisms associated with pain persistence and the mechanisms of action of interventions for subjects with chronic musculoskeletal pain. The main focus of this thesis was to discuss in depth the possible underlying mechanisms associated with pain persistence and recovery in an effort to contribute to the bridging of this gap of knowledge throught four researchs. The first three studies investigated assumptions of current hypothesis about pain persistence through the lens of learning theories, by verifyng if (1) pain can be conditioned to movements through associative learning; (2) investigating which factors were associated with pain distribution through movements and daily activities commonly reported as painful by subjects with chronic pain; and by (3) investigating if chronic musculoskeletal pain is associated with perceptual distortions in other perceptual continuums associated with movements that could foster avoidance behaviors. The last study of this thesis was (4) a systematic review that aimed to systematically identify and synthesise studies that conducted mediation analyses of randomized controlled trials that test or estimate indirect effects of cognitive-behavioral and exercise-based interventions for pain and disability in people with chronic musculoskeletal pain. The basis for the conduction of these studies, as well as its main findings were discussed throughout this thesisApesar do entendimento sobre a neurobiologia da dor ter aumentado exponencialmente ao longo das últimas décadas, ainda existem lacunas de conhecimento importantes relacionadas aos mecanismos associados à persistência da dor e aos mecanismos de ação de abordagens voltadas para o tratamento da dor musculoesquelética crônica. O objetivo desta tese foi contribuir para o preenchimento desta lacuna de conhecimento através da condução de quatro estudos. Os primeiros três estudos investigaram premissas de hipóteses atuais sobre a persistência da dor por uma perspectiva de teorias de aprendizagem, investigando (1) se a dor pode ser condicionada ao movimento através de aprendizado associativo; (2) os fatores associados com a sua manifestação clínica através de movimentos e atividades de vida diária comumente relatadas como dolorosas em pacientes com quadros de dor persistente; e (3) a associada da dor musculoesquelética crônica com distorç?es perceptuais em outros contínuos perceptuais relacionados ao movimento que podem estar associados com a manutenção de comportamentos de evitação. O último estudo desta tese foi (4) uma revisão sistemática da literatura científica sobre estudos de mediação, conduzidos a partir de ensaios clínicos randomizados, que avaliaram os mediadores de efeito de intervenç?es baseadas em exercício e cognitivocomportamentais para a dor e função em pacientes com quadros de dor musculoesquelética crônica. As bases para a condução destes estudos e os seus principais achados foram discutidos ao longo da dissertaçãoBiblioteca Digitais de Teses e Dissertações da USPCosta, Marcelo Fernandes daAlaiti, Rafael Krasic2021-07-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttps://www.teses.usp.br/teses/disponiveis/47/47135/tde-01102021-162436/reponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USPLiberar o conteúdo para acesso público.info:eu-repo/semantics/openAccesseng2021-10-04T18:05:02Zoai:teses.usp.br:tde-01102021-162436Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212021-10-04T18:05:02Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain
A dor relacionada ao movimento como uma resposta aprendida: uma investigação dos possíveis mecanismos subjacentes à persistência e melhora da dor relacionada ao movimento em indivíduos com quadros de dor musculoesquelética crônica
title Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain
spellingShingle Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain
Alaiti, Rafael Krasic
Aprendizagem
Behavior
Chronic pain
Comportamento
Dor
Dor crônica
Learning
Mecanismos de ação
Mechanisms of action
Pain
title_short Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain
title_full Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain
title_fullStr Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain
title_full_unstemmed Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain
title_sort Movement-related pain as a learned response: an investigation of the possible mechanisms underlyng movement-related pain persistence and recovery in subjects with chronic musculoskeletal pain
author Alaiti, Rafael Krasic
author_facet Alaiti, Rafael Krasic
author_role author
dc.contributor.none.fl_str_mv Costa, Marcelo Fernandes da
dc.contributor.author.fl_str_mv Alaiti, Rafael Krasic
dc.subject.por.fl_str_mv Aprendizagem
Behavior
Chronic pain
Comportamento
Dor
Dor crônica
Learning
Mecanismos de ação
Mechanisms of action
Pain
topic Aprendizagem
Behavior
Chronic pain
Comportamento
Dor
Dor crônica
Learning
Mecanismos de ação
Mechanisms of action
Pain
description Although our understanding about pain neurobiology have increased over the last decades, there is still a gap of knowledge regarding the understanding of the mechanisms associated with pain persistence and the mechanisms of action of interventions for subjects with chronic musculoskeletal pain. The main focus of this thesis was to discuss in depth the possible underlying mechanisms associated with pain persistence and recovery in an effort to contribute to the bridging of this gap of knowledge throught four researchs. The first three studies investigated assumptions of current hypothesis about pain persistence through the lens of learning theories, by verifyng if (1) pain can be conditioned to movements through associative learning; (2) investigating which factors were associated with pain distribution through movements and daily activities commonly reported as painful by subjects with chronic pain; and by (3) investigating if chronic musculoskeletal pain is associated with perceptual distortions in other perceptual continuums associated with movements that could foster avoidance behaviors. The last study of this thesis was (4) a systematic review that aimed to systematically identify and synthesise studies that conducted mediation analyses of randomized controlled trials that test or estimate indirect effects of cognitive-behavioral and exercise-based interventions for pain and disability in people with chronic musculoskeletal pain. The basis for the conduction of these studies, as well as its main findings were discussed throughout this thesis
publishDate 2021
dc.date.none.fl_str_mv 2021-07-26
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
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dc.identifier.uri.fl_str_mv https://www.teses.usp.br/teses/disponiveis/47/47135/tde-01102021-162436/
url https://www.teses.usp.br/teses/disponiveis/47/47135/tde-01102021-162436/
dc.language.iso.fl_str_mv eng
language eng
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dc.rights.driver.fl_str_mv Liberar o conteúdo para acesso público.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Liberar o conteúdo para acesso público.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
dc.source.none.fl_str_mv
reponame:Biblioteca Digital de Teses e Dissertações da USP
instname:Universidade de São Paulo (USP)
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instname_str Universidade de São Paulo (USP)
instacron_str USP
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reponame_str Biblioteca Digital de Teses e Dissertações da USP
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repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)
repository.mail.fl_str_mv virginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.br
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