Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles

Detalhes bibliográficos
Autor(a) principal: Silva, Lucas José de Azevedo
Data de Publicação: 2023
Tipo de documento: Tese
Idioma: eng
Título da fonte: Biblioteca Digital de Teses e Dissertações da USP
Texto Completo: https://www.teses.usp.br/teses/disponiveis/25/25146/tde-03052024-145229/
Resumo: The aim of this study was to investigate the role of nanostructures on the mechanical properties of ceramic dental materials and to summarize processing and synthesis methodologies for novel ceramics in Dentistry (article 1), and to produce and characterize bovine hydroxyapatite (HA) ceramic composite with addition of 3Y-TZP sintered by different firing curves (article 2). On the article 1, a systematic review was performed guided by PRISMA 2020 statement and registered on PROSPERO (CRD42020201110). The selection criteria included in vitro studies that address results on nanomaterials-modified experimental ceramics for dental application. Most articles studied zirconia, glass-ceramic, and hydroxyapatite matrixes reinforced mainly with metallic oxides having various particle shapes. The most commonly used nanostructures and those that were associated with better mechanical properties for the materials studied are ZrO2 and Al2O3. On article 2, for experimental ceramic production, HA was extracted from bovine bones and nanoparticulated. Discs of pure HA and with 1, 5 and 10wt% 3Y-TZP were subjected to uniaxial and isostatic pressing. Dilatometry analysis was performed by a 1300ºC sintering temperature. Three different firing curves were designed for groups sintering: conventional, 1300ºC; 2-step, 1292ºC; 2-step, 1420ºC. The samples were analyzed by X-ray diffraction (XRD), biaxial flexural strength (BFS), Vickers microhardness (VH) and Field emission scan electron microscopy (FE-SEM). Twenty-two articles were selected for analysis for the systematic review. Most articles studied zirconia, glass-ceramic, and hydroxyapatite matrixes reinforced mainly with metallic oxides having various particle shapes. The most commonly used nanostructures and those that were associated with better mechanical properties for the materials studied are ZrO2 and Al2O3. On the experimental phase, dilatometry signaled the need for sintering optimization in groups added with 3Y-TZP. XRD demonstrated the characteristic crystallographic peaks of HA in the pure groups and with 1% 3Y-TZP, and decomposition of HA into -TCP and formation of calcium zirconate in the groups with 5 and 10% 3Y-TZP. The groups of pure HA sintered by the conventional curve (131.3 ± 13.5 MPa; 401 ± 12.7 GPa) and HA+1%3Y-TZP (145 ± 8.6 MPa; 507 ± 47.9 GPa), HA+5%3Y-TZP (68.1 ± 14.2 MPa; 183 ± 9.8 GPa) and HA+10%3Y-TZP (55.6 ± 5.1 MPa; 96.1 ± 7.64 GPa) sintered by the 2-step curve at 1420ºC combined the best BFS and VH results. Each material reacts differently in composition and processing changes. The balance between the processing method, sintering process and addition of nanostructures results in microstructural characteristics that enhance the mechanical properties of the materials. The addition of 1 wt% 3YTZP and optimization in the sintering process improved the mechanical and microstructural properties of HA bioceramics and maintenance of its crystalline characteristics.
id USP_cacef7b13d261a0c5f1b570716687c08
oai_identifier_str oai:teses.usp.br:tde-03052024-145229
network_acronym_str USP
network_name_str Biblioteca Digital de Teses e Dissertações da USP
repository_id_str 2721
spelling Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticlesEfeito da incorporação de nanoestruturas nas propriedades mecânicas de cerâmicas odontológicas experimentais: uma revisão sistemática e síntese de biocerâmicas de hidroxiapatita bovina densa com nanopartículas 3Y-TZPbiomateriaisbiomaterialscalcium phosphatesceramic compositescompósitos cerâmicosfosfatos de cálciohidroxiapatitahydroxyapatitenanoparticlenanopartículaszirconiazircôniaThe aim of this study was to investigate the role of nanostructures on the mechanical properties of ceramic dental materials and to summarize processing and synthesis methodologies for novel ceramics in Dentistry (article 1), and to produce and characterize bovine hydroxyapatite (HA) ceramic composite with addition of 3Y-TZP sintered by different firing curves (article 2). On the article 1, a systematic review was performed guided by PRISMA 2020 statement and registered on PROSPERO (CRD42020201110). The selection criteria included in vitro studies that address results on nanomaterials-modified experimental ceramics for dental application. Most articles studied zirconia, glass-ceramic, and hydroxyapatite matrixes reinforced mainly with metallic oxides having various particle shapes. The most commonly used nanostructures and those that were associated with better mechanical properties for the materials studied are ZrO2 and Al2O3. On article 2, for experimental ceramic production, HA was extracted from bovine bones and nanoparticulated. Discs of pure HA and with 1, 5 and 10wt% 3Y-TZP were subjected to uniaxial and isostatic pressing. Dilatometry analysis was performed by a 1300ºC sintering temperature. Three different firing curves were designed for groups sintering: conventional, 1300ºC; 2-step, 1292ºC; 2-step, 1420ºC. The samples were analyzed by X-ray diffraction (XRD), biaxial flexural strength (BFS), Vickers microhardness (VH) and Field emission scan electron microscopy (FE-SEM). Twenty-two articles were selected for analysis for the systematic review. Most articles studied zirconia, glass-ceramic, and hydroxyapatite matrixes reinforced mainly with metallic oxides having various particle shapes. The most commonly used nanostructures and those that were associated with better mechanical properties for the materials studied are ZrO2 and Al2O3. On the experimental phase, dilatometry signaled the need for sintering optimization in groups added with 3Y-TZP. XRD demonstrated the characteristic crystallographic peaks of HA in the pure groups and with 1% 3Y-TZP, and decomposition of HA into -TCP and formation of calcium zirconate in the groups with 5 and 10% 3Y-TZP. The groups of pure HA sintered by the conventional curve (131.3 ± 13.5 MPa; 401 ± 12.7 GPa) and HA+1%3Y-TZP (145 ± 8.6 MPa; 507 ± 47.9 GPa), HA+5%3Y-TZP (68.1 ± 14.2 MPa; 183 ± 9.8 GPa) and HA+10%3Y-TZP (55.6 ± 5.1 MPa; 96.1 ± 7.64 GPa) sintered by the 2-step curve at 1420ºC combined the best BFS and VH results. Each material reacts differently in composition and processing changes. The balance between the processing method, sintering process and addition of nanostructures results in microstructural characteristics that enhance the mechanical properties of the materials. The addition of 1 wt% 3YTZP and optimization in the sintering process improved the mechanical and microstructural properties of HA bioceramics and maintenance of its crystalline characteristics.O objetivo deste estudo foi investigar o papel das nanoestruturas nas propriedades mecânicas de materiais dentários cerâmicos e sintetizar metodologias de processamento de novas cerâmicas na Odontologia (artigo 1), e ainda, produzir e caracterizar compósito cerâmico de hidroxiapatita bovina (HA) com adição de 3Y-TZP sinterizado por diferentes curvas de queima (artigo 2). No artigo 1, foi realizada revisão sistemática da literatura orientada pelo PRISMA 2020 e registrada no PROSPERO (CRD42020201110). Os critérios de seleção incluíram estudos in vitro publicados em periódicos revisados por pares, que abordassem resultados de cerâmicas experimentais modificadas por nanomateriais para aplicação odontológica. O critério de seleção dos artigos incluiu estudos in vitro que avaliassem a performance mecânica de cerâmicas experimentais modificadas por nanoestruturas para uso na odontologia. Vinte e dois artigos foram selecionados para análise da revisão sistemática. A maioria dos artigos estudou matrizes de zircônia, vitrocerâmica e hidroxiapatita reforçadas principalmente com óxidos metálicos com vários formatos de partículas. As nanoestruturas mais utilizadas e que foram associadas às melhores propriedades mecânicas para os materiais estudados foram ZrO2 e Al2O3. No artigo 2, foi realizada a produção experimental de cerâmica, sendo a HA extraída de ossos bovinos por processo termoquímico, seguida de nanoparticulação por moinhos. Discos de HA pura e com adição de 1, 5 e 10wt% de 3Y-TZP, foram submetidos à prensagem uniaxial e isostática. Análise dilatométrica preliminar foi realizada à temperatura máxima de 1300ºC. Três curvas de sinterização foram idealizadas para a sinterização dos grupos: convencional a 1300ºC; 2 etapas a 1292ºC; 2 etapas a 1420ºC. As amostras foram analisadas por difração de raios-X (DRX), resistência à flexão biaxial (RFB), microdureza Vickers (MV) e microscopia eletrônica de varredura (MEV). A dilatometria sinalizou que a curva convencional de sinterização não seria suficiente para sinterizar os grupos adicionados de 3Y-TZP. O DRX demonstrou os picos cristalográficos característicos da HA nos grupos puros e com 3Y-TZP a 1%, e decomposição da HA em -TCP e formação de zirconato de cálcio nos grupos com 5 e 10% de 3Y-TZP. As curvas de sinterização que otimizaram os valores de RFB e MV, respectivamente, de cada grupo foram: curva convencional para o grupo de HA pura (131,3 ± 13,5 MPa; 401 ± 12,7 GPa) e para o grupo HA+1%3Y-TZP (145 ± 8,6 MPa; 507 ± 47,9 GPa); curva de 2 passos a 1420ºC para HA+5%3Y-TZP (68,1 ± 14,2 MPa; 183 ± 9,8 GPa) e para HA+10%3Y-TZP (55,6 ± 5,1 MPa; 96,1 ± 7,64 GPa). O equilíbrio entre a metodologia de processamento, processo de sinterização e adição de nanoestruturas resulta em características microestruturais que potencializam as propriedades mecânicas aos materiais. A adição de 1% em peso de 3Y-TZP na curva de sinterização 2 passos a 1420ºC melhoraram as propriedades mecânicas e microestruturais da biocerâmica de HA, com a manutenção de suas características cristalinas.Biblioteca Digitais de Teses e Dissertações da USPBorges, Ana Flávia SanchesSilva, Lucas José de Azevedo2023-12-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttps://www.teses.usp.br/teses/disponiveis/25/25146/tde-03052024-145229/reponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USPReter o conteúdo por motivos de patente, publicação e/ou direitos autoriais.info:eu-repo/semantics/openAccesseng2024-05-06T13:04:02Zoai:teses.usp.br:tde-03052024-145229Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212024-05-06T13:04:02Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles
Efeito da incorporação de nanoestruturas nas propriedades mecânicas de cerâmicas odontológicas experimentais: uma revisão sistemática e síntese de biocerâmicas de hidroxiapatita bovina densa com nanopartículas 3Y-TZP
title Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles
spellingShingle Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles
Silva, Lucas José de Azevedo
biomateriais
biomaterials
calcium phosphates
ceramic composites
compósitos cerâmicos
fosfatos de cálcio
hidroxiapatita
hydroxyapatite
nanoparticle
nanopartículas
zirconia
zircônia
title_short Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles
title_full Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles
title_fullStr Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles
title_full_unstemmed Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles
title_sort Effect of nanostructure incorporation on the mechanical properties of experimental dental ceramics: a systematic review and synthesis of dense bovine hydroxyapatite bioceramics with 3Y-TZP nanoparticles
author Silva, Lucas José de Azevedo
author_facet Silva, Lucas José de Azevedo
author_role author
dc.contributor.none.fl_str_mv Borges, Ana Flávia Sanches
dc.contributor.author.fl_str_mv Silva, Lucas José de Azevedo
dc.subject.por.fl_str_mv biomateriais
biomaterials
calcium phosphates
ceramic composites
compósitos cerâmicos
fosfatos de cálcio
hidroxiapatita
hydroxyapatite
nanoparticle
nanopartículas
zirconia
zircônia
topic biomateriais
biomaterials
calcium phosphates
ceramic composites
compósitos cerâmicos
fosfatos de cálcio
hidroxiapatita
hydroxyapatite
nanoparticle
nanopartículas
zirconia
zircônia
description The aim of this study was to investigate the role of nanostructures on the mechanical properties of ceramic dental materials and to summarize processing and synthesis methodologies for novel ceramics in Dentistry (article 1), and to produce and characterize bovine hydroxyapatite (HA) ceramic composite with addition of 3Y-TZP sintered by different firing curves (article 2). On the article 1, a systematic review was performed guided by PRISMA 2020 statement and registered on PROSPERO (CRD42020201110). The selection criteria included in vitro studies that address results on nanomaterials-modified experimental ceramics for dental application. Most articles studied zirconia, glass-ceramic, and hydroxyapatite matrixes reinforced mainly with metallic oxides having various particle shapes. The most commonly used nanostructures and those that were associated with better mechanical properties for the materials studied are ZrO2 and Al2O3. On article 2, for experimental ceramic production, HA was extracted from bovine bones and nanoparticulated. Discs of pure HA and with 1, 5 and 10wt% 3Y-TZP were subjected to uniaxial and isostatic pressing. Dilatometry analysis was performed by a 1300ºC sintering temperature. Three different firing curves were designed for groups sintering: conventional, 1300ºC; 2-step, 1292ºC; 2-step, 1420ºC. The samples were analyzed by X-ray diffraction (XRD), biaxial flexural strength (BFS), Vickers microhardness (VH) and Field emission scan electron microscopy (FE-SEM). Twenty-two articles were selected for analysis for the systematic review. Most articles studied zirconia, glass-ceramic, and hydroxyapatite matrixes reinforced mainly with metallic oxides having various particle shapes. The most commonly used nanostructures and those that were associated with better mechanical properties for the materials studied are ZrO2 and Al2O3. On the experimental phase, dilatometry signaled the need for sintering optimization in groups added with 3Y-TZP. XRD demonstrated the characteristic crystallographic peaks of HA in the pure groups and with 1% 3Y-TZP, and decomposition of HA into -TCP and formation of calcium zirconate in the groups with 5 and 10% 3Y-TZP. The groups of pure HA sintered by the conventional curve (131.3 ± 13.5 MPa; 401 ± 12.7 GPa) and HA+1%3Y-TZP (145 ± 8.6 MPa; 507 ± 47.9 GPa), HA+5%3Y-TZP (68.1 ± 14.2 MPa; 183 ± 9.8 GPa) and HA+10%3Y-TZP (55.6 ± 5.1 MPa; 96.1 ± 7.64 GPa) sintered by the 2-step curve at 1420ºC combined the best BFS and VH results. Each material reacts differently in composition and processing changes. The balance between the processing method, sintering process and addition of nanostructures results in microstructural characteristics that enhance the mechanical properties of the materials. The addition of 1 wt% 3YTZP and optimization in the sintering process improved the mechanical and microstructural properties of HA bioceramics and maintenance of its crystalline characteristics.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-04
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.teses.usp.br/teses/disponiveis/25/25146/tde-03052024-145229/
url https://www.teses.usp.br/teses/disponiveis/25/25146/tde-03052024-145229/
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv
dc.rights.driver.fl_str_mv Reter o conteúdo por motivos de patente, publicação e/ou direitos autoriais.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reter o conteúdo por motivos de patente, publicação e/ou direitos autoriais.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv
dc.publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
dc.source.none.fl_str_mv
reponame:Biblioteca Digital de Teses e Dissertações da USP
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Biblioteca Digital de Teses e Dissertações da USP
collection Biblioteca Digital de Teses e Dissertações da USP
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)
repository.mail.fl_str_mv virginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.br
_version_ 1815256636456960000