Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective

Detalhes bibliográficos
Autor(a) principal: Tsukahara, Victor Hugo Batista
Data de Publicação: 2022
Tipo de documento: Tese
Idioma: eng
Título da fonte: Biblioteca Digital de Teses e Dissertações da USP
Texto Completo: https://www.teses.usp.br/teses/disponiveis/18/18153/tde-19122022-123219/
Resumo: Epilepsy is one of the most common neurological disorders worldwide. Recent findings on it suggest that the brain is a complex system based on a network of neurons whose interactions result in an epileptic seizure, which is currently considered an emergent property. Based on such a modern view, network physiology has emerged to address how brain areas coordinate, synchronize and integrate their dynamics during sound health and afflicted conditions.The objective of this thesis is to present an application of (Dynamic) Bayesian Networks (DBN) to model Local Field Potentials (LFP) based on recordings of rats induced to epileptic seizures and arcs evaluated using an analytical threshold approach. A dynamic network model was constructed from data using the Bayesian Network method, either by considering the delay of communication among brain areas recorded in this study or not. To such an end, the Multivariate Stochastic Volatility method was employed to identify the lag among Local Field Potentials and K2 Score so as to compare the models. Results also showed that the DBN analysis has captured the dynamic nature of brain connectivity across ictogenesis, and that there is a significant correlation to neurobiology derived from pioneering studies employing techniques of pharmacological manipulation, lesion, and modern optogenetics. The arcs evaluation under the proposed approach was consistent with previous literature. Moreover, it provided exciting novel insights, such as a discontinuity between forelimb clonus and generalized tonic-clonic seizure (GTCS) dynamics. Dynamic Bayesian Network depicted the evolution of rats\' brains from resting-state until the generalized tonic-clonic seizure. Multivariate Stochastic Volatility captured the lag among brain areas, and better results were yielded after its application on the DBN model.
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spelling Dynamic evaluation of induced epilepsy in rats: a bayesian network perspectiveAvaliação dinâmica da epilepsia induzida em ratos: uma perspectiva de rede bayesianaBayesian networksComplex systemElectroencephalographyEletroencefalografiaEpilepsiaEpilepsyRedes bayesianasSistema complexoStochastic volatilityVolatilidade estocásticaEpilepsy is one of the most common neurological disorders worldwide. Recent findings on it suggest that the brain is a complex system based on a network of neurons whose interactions result in an epileptic seizure, which is currently considered an emergent property. Based on such a modern view, network physiology has emerged to address how brain areas coordinate, synchronize and integrate their dynamics during sound health and afflicted conditions.The objective of this thesis is to present an application of (Dynamic) Bayesian Networks (DBN) to model Local Field Potentials (LFP) based on recordings of rats induced to epileptic seizures and arcs evaluated using an analytical threshold approach. A dynamic network model was constructed from data using the Bayesian Network method, either by considering the delay of communication among brain areas recorded in this study or not. To such an end, the Multivariate Stochastic Volatility method was employed to identify the lag among Local Field Potentials and K2 Score so as to compare the models. Results also showed that the DBN analysis has captured the dynamic nature of brain connectivity across ictogenesis, and that there is a significant correlation to neurobiology derived from pioneering studies employing techniques of pharmacological manipulation, lesion, and modern optogenetics. The arcs evaluation under the proposed approach was consistent with previous literature. Moreover, it provided exciting novel insights, such as a discontinuity between forelimb clonus and generalized tonic-clonic seizure (GTCS) dynamics. Dynamic Bayesian Network depicted the evolution of rats\' brains from resting-state until the generalized tonic-clonic seizure. Multivariate Stochastic Volatility captured the lag among brain areas, and better results were yielded after its application on the DBN model.A epilepsia é uma das doenças neurológicas mais comuns em todo o mundo. Considerando o cérebro um sistema complexo, estudos tem utilizado esta abordagem para realizar análise de conectividade funcional para indivíduos saudáveis, bem como acometidos pela patologia. A tese apresenta a aplicação das Redes Bayesianas (Dinâmicas) (DBN) para modelar os registros dos Potenciais de Campo Locais (LFP) de ratos induzidos a convulsões epilépticas, avaliando a influência da variável tempo para as análises. Os resultados mostraram que a análise DBN captou a natureza dinâmica da conectividade cerebral através da ictogênese com uma correlação significativa com a neurobiologia derivada de estudos pioneiros que empregavam técnicas de manipulação farmacológica, lesão e optogênese moderna. A avaliação dos arcos sob a abordagem proposta foi consistente com a literatura anterior, propôs novos entendimentos, como a descontinuidade entre o mioclonia de membros inferiores e a dinâmica generalizada da convulsão tônico-clônica (GTCS). Após a incorporação de atrasos entre os registros eletroencefalográficos, houve a indicação de melhor aderência do conjunto de sinais ao modelo DBN.Biblioteca Digitais de Teses e Dissertações da USPMaciel, Carlos DiasTsukahara, Victor Hugo Batista2022-10-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttps://www.teses.usp.br/teses/disponiveis/18/18153/tde-19122022-123219/reponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USPLiberar o conteúdo para acesso público.info:eu-repo/semantics/openAccesseng2022-12-22T19:56:44Zoai:teses.usp.br:tde-19122022-123219Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212022-12-22T19:56:44Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective
Avaliação dinâmica da epilepsia induzida em ratos: uma perspectiva de rede bayesiana
title Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective
spellingShingle Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective
Tsukahara, Victor Hugo Batista
Bayesian networks
Complex system
Electroencephalography
Eletroencefalografia
Epilepsia
Epilepsy
Redes bayesianas
Sistema complexo
Stochastic volatility
Volatilidade estocástica
title_short Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective
title_full Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective
title_fullStr Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective
title_full_unstemmed Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective
title_sort Dynamic evaluation of induced epilepsy in rats: a bayesian network perspective
author Tsukahara, Victor Hugo Batista
author_facet Tsukahara, Victor Hugo Batista
author_role author
dc.contributor.none.fl_str_mv Maciel, Carlos Dias
dc.contributor.author.fl_str_mv Tsukahara, Victor Hugo Batista
dc.subject.por.fl_str_mv Bayesian networks
Complex system
Electroencephalography
Eletroencefalografia
Epilepsia
Epilepsy
Redes bayesianas
Sistema complexo
Stochastic volatility
Volatilidade estocástica
topic Bayesian networks
Complex system
Electroencephalography
Eletroencefalografia
Epilepsia
Epilepsy
Redes bayesianas
Sistema complexo
Stochastic volatility
Volatilidade estocástica
description Epilepsy is one of the most common neurological disorders worldwide. Recent findings on it suggest that the brain is a complex system based on a network of neurons whose interactions result in an epileptic seizure, which is currently considered an emergent property. Based on such a modern view, network physiology has emerged to address how brain areas coordinate, synchronize and integrate their dynamics during sound health and afflicted conditions.The objective of this thesis is to present an application of (Dynamic) Bayesian Networks (DBN) to model Local Field Potentials (LFP) based on recordings of rats induced to epileptic seizures and arcs evaluated using an analytical threshold approach. A dynamic network model was constructed from data using the Bayesian Network method, either by considering the delay of communication among brain areas recorded in this study or not. To such an end, the Multivariate Stochastic Volatility method was employed to identify the lag among Local Field Potentials and K2 Score so as to compare the models. Results also showed that the DBN analysis has captured the dynamic nature of brain connectivity across ictogenesis, and that there is a significant correlation to neurobiology derived from pioneering studies employing techniques of pharmacological manipulation, lesion, and modern optogenetics. The arcs evaluation under the proposed approach was consistent with previous literature. Moreover, it provided exciting novel insights, such as a discontinuity between forelimb clonus and generalized tonic-clonic seizure (GTCS) dynamics. Dynamic Bayesian Network depicted the evolution of rats\' brains from resting-state until the generalized tonic-clonic seizure. Multivariate Stochastic Volatility captured the lag among brain areas, and better results were yielded after its application on the DBN model.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
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dc.rights.driver.fl_str_mv Liberar o conteúdo para acesso público.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Liberar o conteúdo para acesso público.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
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reponame:Biblioteca Digital de Teses e Dissertações da USP
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
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institution USP
reponame_str Biblioteca Digital de Teses e Dissertações da USP
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