Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry

Detalhes bibliográficos
Autor(a) principal: Bolzan, Juliana Aparecida
Data de Publicação: 2020
Outros Autores: Gomes, Sandra Inês Adams Angnes, Sandri, Marilei Casturina Mendes
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Ensino de Ciência e Tecnologia
Texto Completo: https://periodicos.utfpr.edu.br/rbect/article/view/9091
Resumo: This work presents the evaluation of the chemical vegetable for the extraction of the active ingredient of paracetamol 500 mg tablets, with optimization of the process through the holistic metrics of Green Chemistry. The previous analysis, indicated as a possibility the substitution of acetone, conventionally used in this type of extraction, by ethanol. Yield calculations, identification tests, UV-Vis assay and energetic metrics were performed to verify the effectiveness of the results a priori glimpsed. The extraction with ethanol was effective, according to principles 5, 6, 7 and 10 of Green Chemistry, resulting in: solvent reduction and waste reduction, energy gain, and use of renewable and biodegradable solvent. Finally, this study allowed to relate the principles of Green Chemistry with teaching, contributing to a more conscious practice and possible to be implemented in areas such as Pharmaceutical Chemistry, contributing to the training of these professionals from a new perspective.
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spelling Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistryExtração do paracetamol comprimidos: uma técnica verde para o ensino de química farmacêuticaEnsino de Química; Química OrgânicaQuímica Verde; Química Farmacêutica; ParacetamolGreen Chemistry; Chemistry Pharmaceutical; ParacetamolThis work presents the evaluation of the chemical vegetable for the extraction of the active ingredient of paracetamol 500 mg tablets, with optimization of the process through the holistic metrics of Green Chemistry. The previous analysis, indicated as a possibility the substitution of acetone, conventionally used in this type of extraction, by ethanol. Yield calculations, identification tests, UV-Vis assay and energetic metrics were performed to verify the effectiveness of the results a priori glimpsed. The extraction with ethanol was effective, according to principles 5, 6, 7 and 10 of Green Chemistry, resulting in: solvent reduction and waste reduction, energy gain, and use of renewable and biodegradable solvent. Finally, this study allowed to relate the principles of Green Chemistry with teaching, contributing to a more conscious practice and possible to be implemented in areas such as Pharmaceutical Chemistry, contributing to the training of these professionals from a new perspective.Este trabalho apresenta a avaliação da verdura química para a extração do princípio ativo do paracetamol de comprimidos 500 mg, com otimização do processo por meio das métricas holísticas da Química Verde. A análise prévia, apontou como possibilidade a substituição da acetona, convencionalmente utilizada neste tipo de extração, por etanol. Cálculos de rendimento, testes para identificação, doseamento por UV-vis e métricas energéticas foram realizados para verificar a efetividade dos resultados vislumbrados a priori. A extração com etanol foi eficaz, atendendo os princípios 5, 6, 7 e 10 da Química Verde, resultando em: redução de solvente e diminuição de resíduos, ganho energético, e uso de solvente renovável e biodegradável. Por fim, este estudo permitiu relacionar os princípios da Química Verde com o ensino, contribuindo para uma prática mais consciente e possível de ser implementada em áreas como a Química Farmacêutica, contribuindo com a formação destes profissionais sob uma nova perspectiva.Universidade Tecnológica Federal do Paraná (UTFPR)Bolzan, Juliana AparecidaGomes, Sandra Inês Adams AngnesSandri, Marilei Casturina Mendes2020-04-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.utfpr.edu.br/rbect/article/view/909110.3895/rbect.v13n1.9091Revista Brasileira de Ensino de Ciência e Tecnologia; v. 13, n. 1 (2020)1982-873X10.3895/rbect.v13n1reponame:Revista Brasileira de Ensino de Ciência e Tecnologiainstname:Universidade Tecnológica Federal do Paraná (UTFPR)instacron:UTFPRporhttps://periodicos.utfpr.edu.br/rbect/article/view/9091/pdfDireitos autorais 2020 CC-BYhttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess2022-09-29T18:40:52Zoai:periodicos.utfpr:article/9091Revistahttps://periodicos.utfpr.edu.br/rbectPUBhttps://periodicos.utfpr.edu.br/rbect/oai||rbect-pg@utfpr.edu.br1982-873X1982-873Xopendoar:2022-09-29T18:40:52Revista Brasileira de Ensino de Ciência e Tecnologia - Universidade Tecnológica Federal do Paraná (UTFPR)false
dc.title.none.fl_str_mv Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry
Extração do paracetamol comprimidos: uma técnica verde para o ensino de química farmacêutica
title Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry
spellingShingle Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry
Bolzan, Juliana Aparecida
Ensino de Química; Química Orgânica
Química Verde; Química Farmacêutica; Paracetamol
Green Chemistry; Chemistry Pharmaceutical; Paracetamol
title_short Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry
title_full Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry
title_fullStr Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry
title_full_unstemmed Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry
title_sort Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry
author Bolzan, Juliana Aparecida
author_facet Bolzan, Juliana Aparecida
Gomes, Sandra Inês Adams Angnes
Sandri, Marilei Casturina Mendes
author_role author
author2 Gomes, Sandra Inês Adams Angnes
Sandri, Marilei Casturina Mendes
author2_role author
author
dc.contributor.none.fl_str_mv

dc.contributor.author.fl_str_mv Bolzan, Juliana Aparecida
Gomes, Sandra Inês Adams Angnes
Sandri, Marilei Casturina Mendes
dc.subject.por.fl_str_mv Ensino de Química; Química Orgânica
Química Verde; Química Farmacêutica; Paracetamol
Green Chemistry; Chemistry Pharmaceutical; Paracetamol
topic Ensino de Química; Química Orgânica
Química Verde; Química Farmacêutica; Paracetamol
Green Chemistry; Chemistry Pharmaceutical; Paracetamol
description This work presents the evaluation of the chemical vegetable for the extraction of the active ingredient of paracetamol 500 mg tablets, with optimization of the process through the holistic metrics of Green Chemistry. The previous analysis, indicated as a possibility the substitution of acetone, conventionally used in this type of extraction, by ethanol. Yield calculations, identification tests, UV-Vis assay and energetic metrics were performed to verify the effectiveness of the results a priori glimpsed. The extraction with ethanol was effective, according to principles 5, 6, 7 and 10 of Green Chemistry, resulting in: solvent reduction and waste reduction, energy gain, and use of renewable and biodegradable solvent. Finally, this study allowed to relate the principles of Green Chemistry with teaching, contributing to a more conscious practice and possible to be implemented in areas such as Pharmaceutical Chemistry, contributing to the training of these professionals from a new perspective.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-15
dc.type.none.fl_str_mv

dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.utfpr.edu.br/rbect/article/view/9091
10.3895/rbect.v13n1.9091
url https://periodicos.utfpr.edu.br/rbect/article/view/9091
identifier_str_mv 10.3895/rbect.v13n1.9091
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.utfpr.edu.br/rbect/article/view/9091/pdf
dc.rights.driver.fl_str_mv Direitos autorais 2020 CC-BY
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos autorais 2020 CC-BY
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Tecnológica Federal do Paraná (UTFPR)
publisher.none.fl_str_mv Universidade Tecnológica Federal do Paraná (UTFPR)
dc.source.none.fl_str_mv Revista Brasileira de Ensino de Ciência e Tecnologia; v. 13, n. 1 (2020)
1982-873X
10.3895/rbect.v13n1
reponame:Revista Brasileira de Ensino de Ciência e Tecnologia
instname:Universidade Tecnológica Federal do Paraná (UTFPR)
instacron:UTFPR
instname_str Universidade Tecnológica Federal do Paraná (UTFPR)
instacron_str UTFPR
institution UTFPR
reponame_str Revista Brasileira de Ensino de Ciência e Tecnologia
collection Revista Brasileira de Ensino de Ciência e Tecnologia
repository.name.fl_str_mv Revista Brasileira de Ensino de Ciência e Tecnologia - Universidade Tecnológica Federal do Paraná (UTFPR)
repository.mail.fl_str_mv ||rbect-pg@utfpr.edu.br
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