Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Veras |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765 |
Resumo: | Introduction: Molecular hybridization is a synthesis strategy in which new molecules are obtained by linking two drugs or pharmacophoric groups. Skin conditions treatment, such as acne, generally requires the association of drugs, for instance, sulfacetamide and salicylic acid. The present study aimed to synthesize and characterize a new drug candidate by molecular hybridization using sulfacetamide and salicylic acid. We also intended to further explore and evaluate this synthesis as a practical educational strategy for undergraduate students. Methods: The synthesis was carried out through an azo coupling reaction between the aromatic amine from sulfacetamide and the ring from salicylic acid. The compound obtained was characterized by melting point and infrared spectroscopy (IR). A short course was developed and applied to evaluate the impact of this synthesis and its discussion in class. The evaluation was performed using an initial and a final questionnaire. Results: The compound was obtained as an orange solid (41%), with a melting point of 108 ºC, and showing as main IR bands: 3247-3041 cm-1, 1662 cm-1, 1608 cm-1, 1439 cm-1. The data from the questionnaires showed that the students improve their knowledge of drug development strategies (73%). Discussion: The experimental evidences suggest the formation of a new chemical entity, possibly the proposed hybrid. Besides, the questionnaire results suggest that new teaching methodologies mixing theoretical-practical moments, allowed students to better understand a specific issue. Conclusion: The proposal synthesis showed to be viable and an interesting possibility to approach several issues with pharmacy undergraduate students in a multidisciplinary way. |
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Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagemorganic synthesisdiazotizationshort coursepharmacy education.Introduction: Molecular hybridization is a synthesis strategy in which new molecules are obtained by linking two drugs or pharmacophoric groups. Skin conditions treatment, such as acne, generally requires the association of drugs, for instance, sulfacetamide and salicylic acid. The present study aimed to synthesize and characterize a new drug candidate by molecular hybridization using sulfacetamide and salicylic acid. We also intended to further explore and evaluate this synthesis as a practical educational strategy for undergraduate students. Methods: The synthesis was carried out through an azo coupling reaction between the aromatic amine from sulfacetamide and the ring from salicylic acid. The compound obtained was characterized by melting point and infrared spectroscopy (IR). A short course was developed and applied to evaluate the impact of this synthesis and its discussion in class. The evaluation was performed using an initial and a final questionnaire. Results: The compound was obtained as an orange solid (41%), with a melting point of 108 ºC, and showing as main IR bands: 3247-3041 cm-1, 1662 cm-1, 1608 cm-1, 1439 cm-1. The data from the questionnaires showed that the students improve their knowledge of drug development strategies (73%). Discussion: The experimental evidences suggest the formation of a new chemical entity, possibly the proposed hybrid. Besides, the questionnaire results suggest that new teaching methodologies mixing theoretical-practical moments, allowed students to better understand a specific issue. Conclusion: The proposal synthesis showed to be viable and an interesting possibility to approach several issues with pharmacy undergraduate students in a multidisciplinary way.Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-03-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/2576510.34117/bjdv7n3-096Brazilian Journal of Development; Vol. 7 No. 3 (2021); 22223-22233Brazilian Journal of Development; Vol. 7 Núm. 3 (2021); 22223-22233Brazilian Journal of Development; v. 7 n. 3 (2021); 22223-222332525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZporhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765/20476Copyright (c) 2021 Brazilian Journal of Developmentinfo:eu-repo/semantics/openAccessdos Santos, Leyliane Teixeira DiasTeixeira, Mariana LopesCarneiro, Jaqueline2022-03-29T12:14:55Zoai:ojs2.ojs.brazilianjournals.com.br:article/25765Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:14:01.006376Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false |
dc.title.none.fl_str_mv |
Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem |
title |
Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem |
spellingShingle |
Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem dos Santos, Leyliane Teixeira Dias organic synthesis diazotization short course pharmacy education. |
title_short |
Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem |
title_full |
Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem |
title_fullStr |
Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem |
title_full_unstemmed |
Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem |
title_sort |
Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem |
author |
dos Santos, Leyliane Teixeira Dias |
author_facet |
dos Santos, Leyliane Teixeira Dias Teixeira, Mariana Lopes Carneiro, Jaqueline |
author_role |
author |
author2 |
Teixeira, Mariana Lopes Carneiro, Jaqueline |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
dos Santos, Leyliane Teixeira Dias Teixeira, Mariana Lopes Carneiro, Jaqueline |
dc.subject.por.fl_str_mv |
organic synthesis diazotization short course pharmacy education. |
topic |
organic synthesis diazotization short course pharmacy education. |
description |
Introduction: Molecular hybridization is a synthesis strategy in which new molecules are obtained by linking two drugs or pharmacophoric groups. Skin conditions treatment, such as acne, generally requires the association of drugs, for instance, sulfacetamide and salicylic acid. The present study aimed to synthesize and characterize a new drug candidate by molecular hybridization using sulfacetamide and salicylic acid. We also intended to further explore and evaluate this synthesis as a practical educational strategy for undergraduate students. Methods: The synthesis was carried out through an azo coupling reaction between the aromatic amine from sulfacetamide and the ring from salicylic acid. The compound obtained was characterized by melting point and infrared spectroscopy (IR). A short course was developed and applied to evaluate the impact of this synthesis and its discussion in class. The evaluation was performed using an initial and a final questionnaire. Results: The compound was obtained as an orange solid (41%), with a melting point of 108 ºC, and showing as main IR bands: 3247-3041 cm-1, 1662 cm-1, 1608 cm-1, 1439 cm-1. The data from the questionnaires showed that the students improve their knowledge of drug development strategies (73%). Discussion: The experimental evidences suggest the formation of a new chemical entity, possibly the proposed hybrid. Besides, the questionnaire results suggest that new teaching methodologies mixing theoretical-practical moments, allowed students to better understand a specific issue. Conclusion: The proposal synthesis showed to be viable and an interesting possibility to approach several issues with pharmacy undergraduate students in a multidisciplinary way. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765 10.34117/bjdv7n3-096 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765 |
identifier_str_mv |
10.34117/bjdv7n3-096 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765/20476 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Brazilian Journal of Development info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Brazilian Journal of Development |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Development; Vol. 7 No. 3 (2021); 22223-22233 Brazilian Journal of Development; Vol. 7 Núm. 3 (2021); 22223-22233 Brazilian Journal of Development; v. 7 n. 3 (2021); 22223-22233 2525-8761 reponame:Revista Veras instname:Instituto Superior de Educação Vera Cruz (VeraCruz) instacron:VERACRUZ |
instname_str |
Instituto Superior de Educação Vera Cruz (VeraCruz) |
instacron_str |
VERACRUZ |
institution |
VERACRUZ |
reponame_str |
Revista Veras |
collection |
Revista Veras |
repository.name.fl_str_mv |
Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz) |
repository.mail.fl_str_mv |
||revistaveras@veracruz.edu.br |
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1813645515509727232 |