Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem

Detalhes bibliográficos
Autor(a) principal: dos Santos, Leyliane Teixeira Dias
Data de Publicação: 2021
Outros Autores: Teixeira, Mariana Lopes, Carneiro, Jaqueline
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Veras
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765
Resumo: Introduction: Molecular hybridization is a synthesis strategy in which new molecules are obtained by linking two drugs or pharmacophoric groups. Skin conditions treatment, such as acne, generally  requires the association of drugs, for instance, sulfacetamide and salicylic acid. The present study aimed to synthesize and characterize a new drug candidate by molecular hybridization using sulfacetamide and salicylic acid. We also intended to further explore and evaluate this synthesis as a practical educational strategy for undergraduate students. Methods: The synthesis was carried out through an azo coupling reaction between the aromatic amine from sulfacetamide and the ring from salicylic acid. The compound obtained was characterized by melting point and infrared spectroscopy (IR). A short course was developed and applied to evaluate the impact of this synthesis and its discussion in class. The evaluation was performed using an initial and a final questionnaire. Results: The compound was obtained as an orange solid (41%), with a melting point of 108 ºC, and showing as main IR bands: 3247-3041 cm-1, 1662 cm-1, 1608 cm-1, 1439 cm-1. The data from the questionnaires showed that the students improve their knowledge of drug development strategies (73%). Discussion: The experimental evidences suggest the formation of a new chemical entity, possibly the proposed hybrid. Besides, the questionnaire results suggest that new teaching methodologies mixing theoretical-practical moments, allowed students to better understand a specific issue. Conclusion: The proposal synthesis showed to be viable and an interesting possibility to approach several issues with pharmacy undergraduate students in a multidisciplinary way.
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spelling Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagemorganic synthesisdiazotizationshort coursepharmacy education.Introduction: Molecular hybridization is a synthesis strategy in which new molecules are obtained by linking two drugs or pharmacophoric groups. Skin conditions treatment, such as acne, generally  requires the association of drugs, for instance, sulfacetamide and salicylic acid. The present study aimed to synthesize and characterize a new drug candidate by molecular hybridization using sulfacetamide and salicylic acid. We also intended to further explore and evaluate this synthesis as a practical educational strategy for undergraduate students. Methods: The synthesis was carried out through an azo coupling reaction between the aromatic amine from sulfacetamide and the ring from salicylic acid. The compound obtained was characterized by melting point and infrared spectroscopy (IR). A short course was developed and applied to evaluate the impact of this synthesis and its discussion in class. The evaluation was performed using an initial and a final questionnaire. Results: The compound was obtained as an orange solid (41%), with a melting point of 108 ºC, and showing as main IR bands: 3247-3041 cm-1, 1662 cm-1, 1608 cm-1, 1439 cm-1. The data from the questionnaires showed that the students improve their knowledge of drug development strategies (73%). Discussion: The experimental evidences suggest the formation of a new chemical entity, possibly the proposed hybrid. Besides, the questionnaire results suggest that new teaching methodologies mixing theoretical-practical moments, allowed students to better understand a specific issue. Conclusion: The proposal synthesis showed to be viable and an interesting possibility to approach several issues with pharmacy undergraduate students in a multidisciplinary way.Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-03-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/2576510.34117/bjdv7n3-096Brazilian Journal of Development; Vol. 7 No. 3 (2021); 22223-22233Brazilian Journal of Development; Vol. 7 Núm. 3 (2021); 22223-22233Brazilian Journal of Development; v. 7 n. 3 (2021); 22223-222332525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZporhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765/20476Copyright (c) 2021 Brazilian Journal of Developmentinfo:eu-repo/semantics/openAccessdos Santos, Leyliane Teixeira DiasTeixeira, Mariana LopesCarneiro, Jaqueline2022-03-29T12:14:55Zoai:ojs2.ojs.brazilianjournals.com.br:article/25765Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:14:01.006376Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false
dc.title.none.fl_str_mv Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
title Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
spellingShingle Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
dos Santos, Leyliane Teixeira Dias
organic synthesis
diazotization
short course
pharmacy education.
title_short Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
title_full Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
title_fullStr Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
title_full_unstemmed Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
title_sort Synthesis of a new drug candidate trough molecular hybridization and application as a learning strategy / Síntese de um novo candidato à fármaco através de hibridação molecular e aplicação como estratégia de aprendizagem
author dos Santos, Leyliane Teixeira Dias
author_facet dos Santos, Leyliane Teixeira Dias
Teixeira, Mariana Lopes
Carneiro, Jaqueline
author_role author
author2 Teixeira, Mariana Lopes
Carneiro, Jaqueline
author2_role author
author
dc.contributor.author.fl_str_mv dos Santos, Leyliane Teixeira Dias
Teixeira, Mariana Lopes
Carneiro, Jaqueline
dc.subject.por.fl_str_mv organic synthesis
diazotization
short course
pharmacy education.
topic organic synthesis
diazotization
short course
pharmacy education.
description Introduction: Molecular hybridization is a synthesis strategy in which new molecules are obtained by linking two drugs or pharmacophoric groups. Skin conditions treatment, such as acne, generally  requires the association of drugs, for instance, sulfacetamide and salicylic acid. The present study aimed to synthesize and characterize a new drug candidate by molecular hybridization using sulfacetamide and salicylic acid. We also intended to further explore and evaluate this synthesis as a practical educational strategy for undergraduate students. Methods: The synthesis was carried out through an azo coupling reaction between the aromatic amine from sulfacetamide and the ring from salicylic acid. The compound obtained was characterized by melting point and infrared spectroscopy (IR). A short course was developed and applied to evaluate the impact of this synthesis and its discussion in class. The evaluation was performed using an initial and a final questionnaire. Results: The compound was obtained as an orange solid (41%), with a melting point of 108 ºC, and showing as main IR bands: 3247-3041 cm-1, 1662 cm-1, 1608 cm-1, 1439 cm-1. The data from the questionnaires showed that the students improve their knowledge of drug development strategies (73%). Discussion: The experimental evidences suggest the formation of a new chemical entity, possibly the proposed hybrid. Besides, the questionnaire results suggest that new teaching methodologies mixing theoretical-practical moments, allowed students to better understand a specific issue. Conclusion: The proposal synthesis showed to be viable and an interesting possibility to approach several issues with pharmacy undergraduate students in a multidisciplinary way.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-05
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765
10.34117/bjdv7n3-096
url https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765
identifier_str_mv 10.34117/bjdv7n3-096
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/25765/20476
dc.rights.driver.fl_str_mv Copyright (c) 2021 Brazilian Journal of Development
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Brazilian Journal of Development
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Development; Vol. 7 No. 3 (2021); 22223-22233
Brazilian Journal of Development; Vol. 7 Núm. 3 (2021); 22223-22233
Brazilian Journal of Development; v. 7 n. 3 (2021); 22223-22233
2525-8761
reponame:Revista Veras
instname:Instituto Superior de Educação Vera Cruz (VeraCruz)
instacron:VERACRUZ
instname_str Instituto Superior de Educação Vera Cruz (VeraCruz)
instacron_str VERACRUZ
institution VERACRUZ
reponame_str Revista Veras
collection Revista Veras
repository.name.fl_str_mv Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)
repository.mail.fl_str_mv ||revistaveras@veracruz.edu.br
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