Combination of an analgesic and anti-inflammatory to avoid bleaching-induced tooth sensitivity: a randomized, triple-blind clinical trial / Combinação de um analgésico e antiinflamatório para evitar a sensibilidade dental induzida pelo clareamento: um ensaio clínico randomizado triplo-cego

• Autor(a) principal: Alpini, Camila Basso
• Data de Publicação: 2020
• Outros Autores: Naufel, Fabiana Scarparo, Reis, Alessandra, Schmitt, Vera Lucia, Almeida, Leonardo de, Anauate-Netto, Camillo, Maran, Bianca Medeiros, Paula, Eloisa Andrade de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Veras
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/14825
• topic: Dentin Sensitivity; Hydrogen Peroxide; Tooth Bleaching; Clinical Trial.

induced tooth sensitivity (TS). This trial assed if the combination of an analgesic and an anti-inflammatory could reduce bleaching-induced TS. A parallel, placebo-controlled, triple-blind, randomized trial was conducted on 115 healthy adults. The patients received the association of acetaminophen 750 mg/ ketorolac tromethamine 10 mg or placebo, 1 h before the in-office bleaching (35% hydrogen peroxide), and extra doses every 8 h for 48 h. The TS was recorded on VAS 0-10 and NRS 0-4 scales, during bleaching and 1 to 48 h post-bleaching. The color was measured before and one month after dental bleaching using two visual shade guides and spectrophotometer. An intent-to-treat analysis was used to analyze data from all patients who were randomly assigned. No significant difference (p=0.41) in the absolute risk of TS between the acetaminophen/ketorolac group (72%; 95% CI 60 to 82) and placebo (79%; 95% CI 68 to 89) with a relative risk of 0.92; 95% CI 0.7 to 1.1. The mean difference in intensity of TS for VAS was lower in the acetaminophen/ketorolac group in the periods 12 to 24 h (-0.7) and 24 to 48 h (-0.4). A whitening effect was observed in both groups with no statistically significant difference (p>0.05). The administration of the association ketorolac/acetaminophen prior to in-office bleaching did not reduce the risk of TS but reduced the intensity of TS after 12 h in a very small magnitude. clinicaltrial.gov NCT03343392.