Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma

Detalhes bibliográficos
Autor(a) principal: Araújo, Patrícia Dias de
Data de Publicação: 2020
Outros Autores: Souza, Ana Paula Duarte de, Bonorino, Cristina Beatriz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Veras
DOI: 10.34117/bjdv6n4-238
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883
Resumo: Objective: The aim of this study was to review the key information about the recent subtype of Th9 cells and interleukin-9 in the pathology of asthma.Data source: It was surveyed in the databases Medline/Pubmed and OVID, original papers published between 1997 and 2012, in English and Spanish, using the selected descriptors.Data synthesis: Asthma is a problem of public health, and its pathophysiology includes subtype of cells of the T helper family and their respective cytokines. The cytokine IL9 is produced by CD4 T cells by activation of transcription factors IRF4 and PU.1. Th9 mainly produce IL9, but Th2 can also secrete this cytokine. IL9 is involved of pathology of asthma by increasing of airway hyperresponsiveness and eotaxin release by lung epithelial cells. Moreover, inhibition of IL9 in asthma has been studied and reported as a preventive and inhibitory airway remodeling in mice.Conclusion: Nowadays, the discovery of new treatments for allergic asthma is essential. Studying this new subtype of helper T cells and understanding its involvement in the development of asthma may provide a possibility of new treatments, such as inhibiting the production of IL9.
id VERACRUZ-0_2ecc2fbcf223314d9c4877f2894c17d9
oai_identifier_str oai:ojs2.ojs.brazilianjournals.com.br:article/8883
network_acronym_str VERACRUZ-0
network_name_str Revista Veras
spelling Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asmaInterleukin-9T helper cellsand TGF-?Objective: The aim of this study was to review the key information about the recent subtype of Th9 cells and interleukin-9 in the pathology of asthma.Data source: It was surveyed in the databases Medline/Pubmed and OVID, original papers published between 1997 and 2012, in English and Spanish, using the selected descriptors.Data synthesis: Asthma is a problem of public health, and its pathophysiology includes subtype of cells of the T helper family and their respective cytokines. The cytokine IL9 is produced by CD4 T cells by activation of transcription factors IRF4 and PU.1. Th9 mainly produce IL9, but Th2 can also secrete this cytokine. IL9 is involved of pathology of asthma by increasing of airway hyperresponsiveness and eotaxin release by lung epithelial cells. Moreover, inhibition of IL9 in asthma has been studied and reported as a preventive and inhibitory airway remodeling in mice.Conclusion: Nowadays, the discovery of new treatments for allergic asthma is essential. Studying this new subtype of helper T cells and understanding its involvement in the development of asthma may provide a possibility of new treatments, such as inhibiting the production of IL9.Brazilian Journals Publicações de Periódicos e Editora Ltda.2020-04-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/888310.34117/bjdv6n4-238Brazilian Journal of Development; Vol. 6 No. 4 (2020); 19888-19900Brazilian Journal of Development; Vol. 6 Núm. 4 (2020); 19888-19900Brazilian Journal of Development; v. 6 n. 4 (2020); 19888-199002525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883/7603Copyright (c) 2020 Brazilian Journal of Developmentinfo:eu-repo/semantics/openAccessAraújo, Patrícia Dias deSouza, Ana Paula Duarte deBonorino, Cristina Beatriz2020-05-27T16:17:37Zoai:ojs2.ojs.brazilianjournals.com.br:article/8883Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:06:03.773713Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false
dc.title.none.fl_str_mv Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
title Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
spellingShingle Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
Araújo, Patrícia Dias de
Interleukin-9
T helper cells
and TGF-?
Araújo, Patrícia Dias de
Interleukin-9
T helper cells
and TGF-?
title_short Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
title_full Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
title_fullStr Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
title_full_unstemmed Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
title_sort Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
author Araújo, Patrícia Dias de
author_facet Araújo, Patrícia Dias de
Araújo, Patrícia Dias de
Souza, Ana Paula Duarte de
Bonorino, Cristina Beatriz
Souza, Ana Paula Duarte de
Bonorino, Cristina Beatriz
author_role author
author2 Souza, Ana Paula Duarte de
Bonorino, Cristina Beatriz
author2_role author
author
dc.contributor.author.fl_str_mv Araújo, Patrícia Dias de
Souza, Ana Paula Duarte de
Bonorino, Cristina Beatriz
dc.subject.por.fl_str_mv Interleukin-9
T helper cells
and TGF-?
topic Interleukin-9
T helper cells
and TGF-?
description Objective: The aim of this study was to review the key information about the recent subtype of Th9 cells and interleukin-9 in the pathology of asthma.Data source: It was surveyed in the databases Medline/Pubmed and OVID, original papers published between 1997 and 2012, in English and Spanish, using the selected descriptors.Data synthesis: Asthma is a problem of public health, and its pathophysiology includes subtype of cells of the T helper family and their respective cytokines. The cytokine IL9 is produced by CD4 T cells by activation of transcription factors IRF4 and PU.1. Th9 mainly produce IL9, but Th2 can also secrete this cytokine. IL9 is involved of pathology of asthma by increasing of airway hyperresponsiveness and eotaxin release by lung epithelial cells. Moreover, inhibition of IL9 in asthma has been studied and reported as a preventive and inhibitory airway remodeling in mice.Conclusion: Nowadays, the discovery of new treatments for allergic asthma is essential. Studying this new subtype of helper T cells and understanding its involvement in the development of asthma may provide a possibility of new treatments, such as inhibiting the production of IL9.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883
10.34117/bjdv6n4-238
url https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883
identifier_str_mv 10.34117/bjdv6n4-238
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883/7603
dc.rights.driver.fl_str_mv Copyright (c) 2020 Brazilian Journal of Development
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Brazilian Journal of Development
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Development; Vol. 6 No. 4 (2020); 19888-19900
Brazilian Journal of Development; Vol. 6 Núm. 4 (2020); 19888-19900
Brazilian Journal of Development; v. 6 n. 4 (2020); 19888-19900
2525-8761
reponame:Revista Veras
instname:Instituto Superior de Educação Vera Cruz (VeraCruz)
instacron:VERACRUZ
instname_str Instituto Superior de Educação Vera Cruz (VeraCruz)
instacron_str VERACRUZ
institution VERACRUZ
reponame_str Revista Veras
collection Revista Veras
repository.name.fl_str_mv Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)
repository.mail.fl_str_mv ||revistaveras@veracruz.edu.br
_version_ 1822183719893467136
dc.identifier.doi.none.fl_str_mv 10.34117/bjdv6n4-238