Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Veras |
DOI: | 10.34117/bjdv6n4-238 |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883 |
Resumo: | Objective: The aim of this study was to review the key information about the recent subtype of Th9 cells and interleukin-9 in the pathology of asthma.Data source: It was surveyed in the databases Medline/Pubmed and OVID, original papers published between 1997 and 2012, in English and Spanish, using the selected descriptors.Data synthesis: Asthma is a problem of public health, and its pathophysiology includes subtype of cells of the T helper family and their respective cytokines. The cytokine IL9 is produced by CD4 T cells by activation of transcription factors IRF4 and PU.1. Th9 mainly produce IL9, but Th2 can also secrete this cytokine. IL9 is involved of pathology of asthma by increasing of airway hyperresponsiveness and eotaxin release by lung epithelial cells. Moreover, inhibition of IL9 in asthma has been studied and reported as a preventive and inhibitory airway remodeling in mice.Conclusion: Nowadays, the discovery of new treatments for allergic asthma is essential. Studying this new subtype of helper T cells and understanding its involvement in the development of asthma may provide a possibility of new treatments, such as inhibiting the production of IL9. |
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Revista Veras |
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Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asmaInterleukin-9T helper cellsand TGF-?Objective: The aim of this study was to review the key information about the recent subtype of Th9 cells and interleukin-9 in the pathology of asthma.Data source: It was surveyed in the databases Medline/Pubmed and OVID, original papers published between 1997 and 2012, in English and Spanish, using the selected descriptors.Data synthesis: Asthma is a problem of public health, and its pathophysiology includes subtype of cells of the T helper family and their respective cytokines. The cytokine IL9 is produced by CD4 T cells by activation of transcription factors IRF4 and PU.1. Th9 mainly produce IL9, but Th2 can also secrete this cytokine. IL9 is involved of pathology of asthma by increasing of airway hyperresponsiveness and eotaxin release by lung epithelial cells. Moreover, inhibition of IL9 in asthma has been studied and reported as a preventive and inhibitory airway remodeling in mice.Conclusion: Nowadays, the discovery of new treatments for allergic asthma is essential. Studying this new subtype of helper T cells and understanding its involvement in the development of asthma may provide a possibility of new treatments, such as inhibiting the production of IL9.Brazilian Journals Publicações de Periódicos e Editora Ltda.2020-04-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/888310.34117/bjdv6n4-238Brazilian Journal of Development; Vol. 6 No. 4 (2020); 19888-19900Brazilian Journal of Development; Vol. 6 Núm. 4 (2020); 19888-19900Brazilian Journal of Development; v. 6 n. 4 (2020); 19888-199002525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883/7603Copyright (c) 2020 Brazilian Journal of Developmentinfo:eu-repo/semantics/openAccessAraújo, Patrícia Dias deSouza, Ana Paula Duarte deBonorino, Cristina Beatriz2020-05-27T16:17:37Zoai:ojs2.ojs.brazilianjournals.com.br:article/8883Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:06:03.773713Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false |
dc.title.none.fl_str_mv |
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma |
title |
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma |
spellingShingle |
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma Araújo, Patrícia Dias de Interleukin-9 T helper cells and TGF-? Araújo, Patrícia Dias de Interleukin-9 T helper cells and TGF-? |
title_short |
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma |
title_full |
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma |
title_fullStr |
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma |
title_full_unstemmed |
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma |
title_sort |
Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma |
author |
Araújo, Patrícia Dias de |
author_facet |
Araújo, Patrícia Dias de Araújo, Patrícia Dias de Souza, Ana Paula Duarte de Bonorino, Cristina Beatriz Souza, Ana Paula Duarte de Bonorino, Cristina Beatriz |
author_role |
author |
author2 |
Souza, Ana Paula Duarte de Bonorino, Cristina Beatriz |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Araújo, Patrícia Dias de Souza, Ana Paula Duarte de Bonorino, Cristina Beatriz |
dc.subject.por.fl_str_mv |
Interleukin-9 T helper cells and TGF-? |
topic |
Interleukin-9 T helper cells and TGF-? |
description |
Objective: The aim of this study was to review the key information about the recent subtype of Th9 cells and interleukin-9 in the pathology of asthma.Data source: It was surveyed in the databases Medline/Pubmed and OVID, original papers published between 1997 and 2012, in English and Spanish, using the selected descriptors.Data synthesis: Asthma is a problem of public health, and its pathophysiology includes subtype of cells of the T helper family and their respective cytokines. The cytokine IL9 is produced by CD4 T cells by activation of transcription factors IRF4 and PU.1. Th9 mainly produce IL9, but Th2 can also secrete this cytokine. IL9 is involved of pathology of asthma by increasing of airway hyperresponsiveness and eotaxin release by lung epithelial cells. Moreover, inhibition of IL9 in asthma has been studied and reported as a preventive and inhibitory airway remodeling in mice.Conclusion: Nowadays, the discovery of new treatments for allergic asthma is essential. Studying this new subtype of helper T cells and understanding its involvement in the development of asthma may provide a possibility of new treatments, such as inhibiting the production of IL9. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883 10.34117/bjdv6n4-238 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883 |
identifier_str_mv |
10.34117/bjdv6n4-238 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/8883/7603 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Brazilian Journal of Development info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Brazilian Journal of Development |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Development; Vol. 6 No. 4 (2020); 19888-19900 Brazilian Journal of Development; Vol. 6 Núm. 4 (2020); 19888-19900 Brazilian Journal of Development; v. 6 n. 4 (2020); 19888-19900 2525-8761 reponame:Revista Veras instname:Instituto Superior de Educação Vera Cruz (VeraCruz) instacron:VERACRUZ |
instname_str |
Instituto Superior de Educação Vera Cruz (VeraCruz) |
instacron_str |
VERACRUZ |
institution |
VERACRUZ |
reponame_str |
Revista Veras |
collection |
Revista Veras |
repository.name.fl_str_mv |
Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz) |
repository.mail.fl_str_mv |
||revistaveras@veracruz.edu.br |
_version_ |
1822183719893467136 |
dc.identifier.doi.none.fl_str_mv |
10.34117/bjdv6n4-238 |