Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Veras |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163 |
Resumo: | The objective was to report the injuries on liver and kidney promoted by experimental colorectal carcinogenesis induction in rats and evaluate the effect of supplementation with Euterpe edulis M. pulp products on resolution of this injuries. Colorectal carcinogenesis with 1,2-dimethylhydrazine was induced in young male rats, allocated into: C - induced to carcinogenesis; CJ - induced to carcinogenesis and supplemented with juçara fruit pulp; and CE - induced to carcinogenesis and supplemented with juçara fruit lyophilized extract. Nine animals were a negative control. Supplementation occurred three times a week, totaling 54 days of administration with 1 mg of cyanidin-3-glycoside per kilogram live weight. The hepatic and renal histopathological injuries were assessed at 10 and 23 weeks. In liver, at 10-week biliary hyperplasia was more evident in colorectal cancer induced groups compared to N group (p = 0.0230), as well as megalocytosis (p = 0.0269), and juçara fruit-based product do not promote cytoprotection. At 23-week biliary hyperplasia continued present, and liver necrosis was evident in C group and CJ group. Hepatic degeneration was greater in C group, and megalocytosis was evident in the cancer-induced groups, without cytoprotection by juçara fruit-based product. In kidney, at 23-week, renal congestion was more evident in CJ group, and tubular degeneration in C and CE groups. Important hepatic and renal injuries were observed in rats induced to colorectal cancer and the supplementation with juçara fruit-based product, in the dose used, did not interfere in the prevention and resolution of these injuries, mainly with the chronic use. |
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Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológicacarcinogenesisexperimental modelliver injuriesrenal injuriesbiocompoundsThe objective was to report the injuries on liver and kidney promoted by experimental colorectal carcinogenesis induction in rats and evaluate the effect of supplementation with Euterpe edulis M. pulp products on resolution of this injuries. Colorectal carcinogenesis with 1,2-dimethylhydrazine was induced in young male rats, allocated into: C - induced to carcinogenesis; CJ - induced to carcinogenesis and supplemented with juçara fruit pulp; and CE - induced to carcinogenesis and supplemented with juçara fruit lyophilized extract. Nine animals were a negative control. Supplementation occurred three times a week, totaling 54 days of administration with 1 mg of cyanidin-3-glycoside per kilogram live weight. The hepatic and renal histopathological injuries were assessed at 10 and 23 weeks. In liver, at 10-week biliary hyperplasia was more evident in colorectal cancer induced groups compared to N group (p = 0.0230), as well as megalocytosis (p = 0.0269), and juçara fruit-based product do not promote cytoprotection. At 23-week biliary hyperplasia continued present, and liver necrosis was evident in C group and CJ group. Hepatic degeneration was greater in C group, and megalocytosis was evident in the cancer-induced groups, without cytoprotection by juçara fruit-based product. In kidney, at 23-week, renal congestion was more evident in CJ group, and tubular degeneration in C and CE groups. Important hepatic and renal injuries were observed in rats induced to colorectal cancer and the supplementation with juçara fruit-based product, in the dose used, did not interfere in the prevention and resolution of these injuries, mainly with the chronic use.Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-10-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/3816310.34117/bjdv7n10-319Brazilian Journal of Development; Vol. 7 No. 10 (2021); 99446-99464Brazilian Journal of Development; Vol. 7 Núm. 10 (2021); 99446-99464Brazilian Journal of Development; v. 7 n. 10 (2021); 99446-994642525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163/pdfCopyright (c) 2021 Brazilian Journal of Developmentinfo:eu-repo/semantics/openAccessPinto, Flávia BarbosaCouto, Cinthia Vidal Monteiro da SilvaArchanjo, Anderson BarrosOliveira, Mayara Motados Santos, Joaquim GaspariniOliveira, Otávio PereiraSilva, Pollyanna IbrahimBoeloni, Jankerle NevesNunes, Louisiane de Carvalhoda Silva, Adriana Madeira ÁlvaresTrivilin, Leonardo Oliveira2022-02-03T19:59:27Zoai:ojs2.ojs.brazilianjournals.com.br:article/38163Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:19:20.081391Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false |
dc.title.none.fl_str_mv |
Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica |
title |
Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica |
spellingShingle |
Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica Pinto, Flávia Barbosa carcinogenesis experimental model liver injuries renal injuries biocompounds |
title_short |
Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica |
title_full |
Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica |
title_fullStr |
Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica |
title_full_unstemmed |
Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica |
title_sort |
Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica |
author |
Pinto, Flávia Barbosa |
author_facet |
Pinto, Flávia Barbosa Couto, Cinthia Vidal Monteiro da Silva Archanjo, Anderson Barros Oliveira, Mayara Mota dos Santos, Joaquim Gasparini Oliveira, Otávio Pereira Silva, Pollyanna Ibrahim Boeloni, Jankerle Neves Nunes, Louisiane de Carvalho da Silva, Adriana Madeira Álvares Trivilin, Leonardo Oliveira |
author_role |
author |
author2 |
Couto, Cinthia Vidal Monteiro da Silva Archanjo, Anderson Barros Oliveira, Mayara Mota dos Santos, Joaquim Gasparini Oliveira, Otávio Pereira Silva, Pollyanna Ibrahim Boeloni, Jankerle Neves Nunes, Louisiane de Carvalho da Silva, Adriana Madeira Álvares Trivilin, Leonardo Oliveira |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pinto, Flávia Barbosa Couto, Cinthia Vidal Monteiro da Silva Archanjo, Anderson Barros Oliveira, Mayara Mota dos Santos, Joaquim Gasparini Oliveira, Otávio Pereira Silva, Pollyanna Ibrahim Boeloni, Jankerle Neves Nunes, Louisiane de Carvalho da Silva, Adriana Madeira Álvares Trivilin, Leonardo Oliveira |
dc.subject.por.fl_str_mv |
carcinogenesis experimental model liver injuries renal injuries biocompounds |
topic |
carcinogenesis experimental model liver injuries renal injuries biocompounds |
description |
The objective was to report the injuries on liver and kidney promoted by experimental colorectal carcinogenesis induction in rats and evaluate the effect of supplementation with Euterpe edulis M. pulp products on resolution of this injuries. Colorectal carcinogenesis with 1,2-dimethylhydrazine was induced in young male rats, allocated into: C - induced to carcinogenesis; CJ - induced to carcinogenesis and supplemented with juçara fruit pulp; and CE - induced to carcinogenesis and supplemented with juçara fruit lyophilized extract. Nine animals were a negative control. Supplementation occurred three times a week, totaling 54 days of administration with 1 mg of cyanidin-3-glycoside per kilogram live weight. The hepatic and renal histopathological injuries were assessed at 10 and 23 weeks. In liver, at 10-week biliary hyperplasia was more evident in colorectal cancer induced groups compared to N group (p = 0.0230), as well as megalocytosis (p = 0.0269), and juçara fruit-based product do not promote cytoprotection. At 23-week biliary hyperplasia continued present, and liver necrosis was evident in C group and CJ group. Hepatic degeneration was greater in C group, and megalocytosis was evident in the cancer-induced groups, without cytoprotection by juçara fruit-based product. In kidney, at 23-week, renal congestion was more evident in CJ group, and tubular degeneration in C and CE groups. Important hepatic and renal injuries were observed in rats induced to colorectal cancer and the supplementation with juçara fruit-based product, in the dose used, did not interfere in the prevention and resolution of these injuries, mainly with the chronic use. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163 10.34117/bjdv7n10-319 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163 |
identifier_str_mv |
10.34117/bjdv7n10-319 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Brazilian Journal of Development info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Brazilian Journal of Development |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Development; Vol. 7 No. 10 (2021); 99446-99464 Brazilian Journal of Development; Vol. 7 Núm. 10 (2021); 99446-99464 Brazilian Journal of Development; v. 7 n. 10 (2021); 99446-99464 2525-8761 reponame:Revista Veras instname:Instituto Superior de Educação Vera Cruz (VeraCruz) instacron:VERACRUZ |
instname_str |
Instituto Superior de Educação Vera Cruz (VeraCruz) |
instacron_str |
VERACRUZ |
institution |
VERACRUZ |
reponame_str |
Revista Veras |
collection |
Revista Veras |
repository.name.fl_str_mv |
Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz) |
repository.mail.fl_str_mv |
||revistaveras@veracruz.edu.br |
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1813645563054260224 |