Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica

Detalhes bibliográficos
Autor(a) principal: Pinto, Flávia Barbosa
Data de Publicação: 2021
Outros Autores: Couto, Cinthia Vidal Monteiro da Silva, Archanjo, Anderson Barros, Oliveira, Mayara Mota, dos Santos, Joaquim Gasparini, Oliveira, Otávio Pereira, Silva, Pollyanna Ibrahim, Boeloni, Jankerle Neves, Nunes, Louisiane de Carvalho, da Silva, Adriana Madeira Álvares, Trivilin, Leonardo Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Veras
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163
Resumo: The objective was to report the injuries on liver and kidney promoted by experimental colorectal carcinogenesis induction in rats and evaluate the effect of supplementation with Euterpe edulis M. pulp products on resolution of this injuries. Colorectal carcinogenesis with 1,2-dimethylhydrazine was induced in young male rats, allocated into: C - induced to carcinogenesis; CJ - induced to carcinogenesis and supplemented with juçara fruit pulp; and CE - induced to carcinogenesis and supplemented with juçara fruit lyophilized extract. Nine animals were a negative control. Supplementation occurred three times a week, totaling 54 days of administration with 1 mg of cyanidin-3-glycoside per kilogram live weight. The hepatic and renal histopathological injuries were assessed at 10 and 23 weeks. In liver, at 10-week biliary hyperplasia was more evident in colorectal cancer induced groups compared to N group (p = 0.0230), as well as megalocytosis (p = 0.0269), and juçara fruit-based product do not promote cytoprotection. At 23-week biliary hyperplasia continued present, and liver necrosis was evident in C group and CJ group. Hepatic degeneration was greater in C group, and megalocytosis was evident in the cancer-induced groups, without cytoprotection by juçara fruit-based product. In kidney, at 23-week, renal congestion was more evident in CJ group, and tubular degeneration in C and CE groups. Important hepatic and renal injuries were observed in rats induced to colorectal cancer and the supplementation with juçara fruit-based product, in the dose used, did not interfere in the prevention and resolution of these injuries, mainly with the chronic use.
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spelling Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológicacarcinogenesisexperimental modelliver injuriesrenal injuriesbiocompoundsThe objective was to report the injuries on liver and kidney promoted by experimental colorectal carcinogenesis induction in rats and evaluate the effect of supplementation with Euterpe edulis M. pulp products on resolution of this injuries. Colorectal carcinogenesis with 1,2-dimethylhydrazine was induced in young male rats, allocated into: C - induced to carcinogenesis; CJ - induced to carcinogenesis and supplemented with juçara fruit pulp; and CE - induced to carcinogenesis and supplemented with juçara fruit lyophilized extract. Nine animals were a negative control. Supplementation occurred three times a week, totaling 54 days of administration with 1 mg of cyanidin-3-glycoside per kilogram live weight. The hepatic and renal histopathological injuries were assessed at 10 and 23 weeks. In liver, at 10-week biliary hyperplasia was more evident in colorectal cancer induced groups compared to N group (p = 0.0230), as well as megalocytosis (p = 0.0269), and juçara fruit-based product do not promote cytoprotection. At 23-week biliary hyperplasia continued present, and liver necrosis was evident in C group and CJ group. Hepatic degeneration was greater in C group, and megalocytosis was evident in the cancer-induced groups, without cytoprotection by juçara fruit-based product. In kidney, at 23-week, renal congestion was more evident in CJ group, and tubular degeneration in C and CE groups. Important hepatic and renal injuries were observed in rats induced to colorectal cancer and the supplementation with juçara fruit-based product, in the dose used, did not interfere in the prevention and resolution of these injuries, mainly with the chronic use.Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-10-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/3816310.34117/bjdv7n10-319Brazilian Journal of Development; Vol. 7 No. 10 (2021); 99446-99464Brazilian Journal of Development; Vol. 7 Núm. 10 (2021); 99446-99464Brazilian Journal of Development; v. 7 n. 10 (2021); 99446-994642525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163/pdfCopyright (c) 2021 Brazilian Journal of Developmentinfo:eu-repo/semantics/openAccessPinto, Flávia BarbosaCouto, Cinthia Vidal Monteiro da SilvaArchanjo, Anderson BarrosOliveira, Mayara Motados Santos, Joaquim GaspariniOliveira, Otávio PereiraSilva, Pollyanna IbrahimBoeloni, Jankerle NevesNunes, Louisiane de Carvalhoda Silva, Adriana Madeira ÁlvaresTrivilin, Leonardo Oliveira2022-02-03T19:59:27Zoai:ojs2.ojs.brazilianjournals.com.br:article/38163Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:19:20.081391Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false
dc.title.none.fl_str_mv Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
title Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
spellingShingle Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
Pinto, Flávia Barbosa
carcinogenesis
experimental model
liver injuries
renal injuries
biocompounds
title_short Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
title_full Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
title_fullStr Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
title_full_unstemmed Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
title_sort Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica
author Pinto, Flávia Barbosa
author_facet Pinto, Flávia Barbosa
Couto, Cinthia Vidal Monteiro da Silva
Archanjo, Anderson Barros
Oliveira, Mayara Mota
dos Santos, Joaquim Gasparini
Oliveira, Otávio Pereira
Silva, Pollyanna Ibrahim
Boeloni, Jankerle Neves
Nunes, Louisiane de Carvalho
da Silva, Adriana Madeira Álvares
Trivilin, Leonardo Oliveira
author_role author
author2 Couto, Cinthia Vidal Monteiro da Silva
Archanjo, Anderson Barros
Oliveira, Mayara Mota
dos Santos, Joaquim Gasparini
Oliveira, Otávio Pereira
Silva, Pollyanna Ibrahim
Boeloni, Jankerle Neves
Nunes, Louisiane de Carvalho
da Silva, Adriana Madeira Álvares
Trivilin, Leonardo Oliveira
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto, Flávia Barbosa
Couto, Cinthia Vidal Monteiro da Silva
Archanjo, Anderson Barros
Oliveira, Mayara Mota
dos Santos, Joaquim Gasparini
Oliveira, Otávio Pereira
Silva, Pollyanna Ibrahim
Boeloni, Jankerle Neves
Nunes, Louisiane de Carvalho
da Silva, Adriana Madeira Álvares
Trivilin, Leonardo Oliveira
dc.subject.por.fl_str_mv carcinogenesis
experimental model
liver injuries
renal injuries
biocompounds
topic carcinogenesis
experimental model
liver injuries
renal injuries
biocompounds
description The objective was to report the injuries on liver and kidney promoted by experimental colorectal carcinogenesis induction in rats and evaluate the effect of supplementation with Euterpe edulis M. pulp products on resolution of this injuries. Colorectal carcinogenesis with 1,2-dimethylhydrazine was induced in young male rats, allocated into: C - induced to carcinogenesis; CJ - induced to carcinogenesis and supplemented with juçara fruit pulp; and CE - induced to carcinogenesis and supplemented with juçara fruit lyophilized extract. Nine animals were a negative control. Supplementation occurred three times a week, totaling 54 days of administration with 1 mg of cyanidin-3-glycoside per kilogram live weight. The hepatic and renal histopathological injuries were assessed at 10 and 23 weeks. In liver, at 10-week biliary hyperplasia was more evident in colorectal cancer induced groups compared to N group (p = 0.0230), as well as megalocytosis (p = 0.0269), and juçara fruit-based product do not promote cytoprotection. At 23-week biliary hyperplasia continued present, and liver necrosis was evident in C group and CJ group. Hepatic degeneration was greater in C group, and megalocytosis was evident in the cancer-induced groups, without cytoprotection by juçara fruit-based product. In kidney, at 23-week, renal congestion was more evident in CJ group, and tubular degeneration in C and CE groups. Important hepatic and renal injuries were observed in rats induced to colorectal cancer and the supplementation with juçara fruit-based product, in the dose used, did not interfere in the prevention and resolution of these injuries, mainly with the chronic use.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163
10.34117/bjdv7n10-319
url https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163
identifier_str_mv 10.34117/bjdv7n10-319
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/38163/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2021 Brazilian Journal of Development
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Brazilian Journal of Development
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Development; Vol. 7 No. 10 (2021); 99446-99464
Brazilian Journal of Development; Vol. 7 Núm. 10 (2021); 99446-99464
Brazilian Journal of Development; v. 7 n. 10 (2021); 99446-99464
2525-8761
reponame:Revista Veras
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reponame_str Revista Veras
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repository.name.fl_str_mv Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)
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