Collagen gene polymorphisms relative to stress urinary incontinence / Associação entre polimorfismos do gene do colágeno e Incontinência urinária de esforço

• Autor(a) principal: Pinheiro, Ana Maria Pearce de Arêa Leão
• Data de Publicação: 2022
• Outros Autores: do Monte, Semiramis Jamil Hadad, da Silva, Adalberto Socorro, Neto, José Machado Moita
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Veras
• DOI: 10.34117/bjdv8n4-251
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/46490
• topic: colia1 gene; sp1 polymorphism; stress urinary incontinence.

Objective: To investigate the possible association between the single-nucleotide polymorphism G→T at the Sp1-binding site at the first intron of the COLIA1 gene and Stress Urinary Incontinence. Study design: We compared the allelic and genotypic frequencies of the COLIA1 gene in patients with SUI (n=29) to those with healthy individuals (n=22). Our strategy was the amplification and the restriction fragment length polymorphism of a DNA fragment with Sp1-binding at the first intron of COLIA1 gene. The results were statistically assessed by Fisher and Mann Whitney’s tests. Results: There were no significant differences between the allelic and genotypic frequencies of COLIA1 gene when comparing individuals with SUI to healthy ones (p=1). Conclusion: The results showed no association between the G→T single-nucleotide polymorphism at the Sp1 binding site at the first intron of the COLIA1 gene and Stress Urinary Incontinence.