Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil

Detalhes bibliográficos
Autor(a) principal: Melo, Ana Paula de
Data de Publicação: 2021
Outros Autores: Delfrate, Gabrielle, Mroczek, Tayline, Jaymes, Arielen Machado, Koga, Adriana Yuriko, Franco, Gilson Cesar Nobre, Claudino, Marcela, Lipinski, Leandro Cavalcante
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Veras
DOI: 10.34117/bjdv7n3-339
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335
Resumo: Diabetes mellitus is a pathology related to changes in glucose metabolism. The hormone insulin acts stimulating intracellular glucose metabolic pathways. The increase in cGMP signaling has the potential to increase insulin sensitivity in the muscle and can stimulate the secretion of this hormone by pancreatic beta cells. Sildenafil (SIL) is a potent peripheral vasodilator that acts attenuating the catabolism of cGMP thus increasing the signaling of the pathways involving the protein kinase G. The present study aimed to evaluate the effect of the sildenafil on hematological and biochemical paramethers in hyperglycemic rats. 55 male Wistar rats were separated into 4 groups: G1 (control), G2 (streptozotocin), G3 (streptozotocin + 10 mg/kg sildenafil) and G4 (streptozotocin + 15 mg/kg sildenafil). The animals received sildenafil during seven days before the application of streptozotocin, maintaining the treatment for another 3 weeks. After euthanasia, hematological and biochemical analyzes were performed. The group that received the highest dose of SIL, showed a decrease in leukocytes compared to the G2 group (p <0.05). In addition, G2 presented thrombocytopenia. Therefore, sildenafil appears to decrease the number of inflammatory cells in hyperglycemic rats in a dose dependent manner.
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spelling Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com SildenafilDiabetes MellitusStreptozotocinInflammationCyclic Guanosine MonophosphateErythrogramLeukogram.Diabetes mellitus is a pathology related to changes in glucose metabolism. The hormone insulin acts stimulating intracellular glucose metabolic pathways. The increase in cGMP signaling has the potential to increase insulin sensitivity in the muscle and can stimulate the secretion of this hormone by pancreatic beta cells. Sildenafil (SIL) is a potent peripheral vasodilator that acts attenuating the catabolism of cGMP thus increasing the signaling of the pathways involving the protein kinase G. The present study aimed to evaluate the effect of the sildenafil on hematological and biochemical paramethers in hyperglycemic rats. 55 male Wistar rats were separated into 4 groups: G1 (control), G2 (streptozotocin), G3 (streptozotocin + 10 mg/kg sildenafil) and G4 (streptozotocin + 15 mg/kg sildenafil). The animals received sildenafil during seven days before the application of streptozotocin, maintaining the treatment for another 3 weeks. After euthanasia, hematological and biochemical analyzes were performed. The group that received the highest dose of SIL, showed a decrease in leukocytes compared to the G2 group (p <0.05). In addition, G2 presented thrombocytopenia. Therefore, sildenafil appears to decrease the number of inflammatory cells in hyperglycemic rats in a dose dependent manner.Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-03-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/2633510.34117/bjdv7n3-339Brazilian Journal of Development; Vol. 7 No. 3 (2021); 25872-25886Brazilian Journal of Development; Vol. 7 Núm. 3 (2021); 25872-25886Brazilian Journal of Development; v. 7 n. 3 (2021); 25872-258862525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335/20883Copyright (c) 2021 Brazilian Journal of Developmentinfo:eu-repo/semantics/openAccessMelo, Ana Paula deDelfrate, GabrielleMroczek, TaylineJaymes, Arielen MachadoKoga, Adriana YurikoFranco, Gilson Cesar NobreClaudino, MarcelaLipinski, Leandro Cavalcante2022-03-29T12:15:33Zoai:ojs2.ojs.brazilianjournals.com.br:article/26335Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:14:15.607739Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false
dc.title.none.fl_str_mv Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
title Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
spellingShingle Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
Melo, Ana Paula de
Diabetes Mellitus
Streptozotocin
Inflammation
Cyclic Guanosine Monophosphate
Erythrogram
Leukogram.
Melo, Ana Paula de
Diabetes Mellitus
Streptozotocin
Inflammation
Cyclic Guanosine Monophosphate
Erythrogram
Leukogram.
title_short Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
title_full Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
title_fullStr Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
title_full_unstemmed Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
title_sort Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
author Melo, Ana Paula de
author_facet Melo, Ana Paula de
Melo, Ana Paula de
Delfrate, Gabrielle
Mroczek, Tayline
Jaymes, Arielen Machado
Koga, Adriana Yuriko
Franco, Gilson Cesar Nobre
Claudino, Marcela
Lipinski, Leandro Cavalcante
Delfrate, Gabrielle
Mroczek, Tayline
Jaymes, Arielen Machado
Koga, Adriana Yuriko
Franco, Gilson Cesar Nobre
Claudino, Marcela
Lipinski, Leandro Cavalcante
author_role author
author2 Delfrate, Gabrielle
Mroczek, Tayline
Jaymes, Arielen Machado
Koga, Adriana Yuriko
Franco, Gilson Cesar Nobre
Claudino, Marcela
Lipinski, Leandro Cavalcante
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Melo, Ana Paula de
Delfrate, Gabrielle
Mroczek, Tayline
Jaymes, Arielen Machado
Koga, Adriana Yuriko
Franco, Gilson Cesar Nobre
Claudino, Marcela
Lipinski, Leandro Cavalcante
dc.subject.por.fl_str_mv Diabetes Mellitus
Streptozotocin
Inflammation
Cyclic Guanosine Monophosphate
Erythrogram
Leukogram.
topic Diabetes Mellitus
Streptozotocin
Inflammation
Cyclic Guanosine Monophosphate
Erythrogram
Leukogram.
description Diabetes mellitus is a pathology related to changes in glucose metabolism. The hormone insulin acts stimulating intracellular glucose metabolic pathways. The increase in cGMP signaling has the potential to increase insulin sensitivity in the muscle and can stimulate the secretion of this hormone by pancreatic beta cells. Sildenafil (SIL) is a potent peripheral vasodilator that acts attenuating the catabolism of cGMP thus increasing the signaling of the pathways involving the protein kinase G. The present study aimed to evaluate the effect of the sildenafil on hematological and biochemical paramethers in hyperglycemic rats. 55 male Wistar rats were separated into 4 groups: G1 (control), G2 (streptozotocin), G3 (streptozotocin + 10 mg/kg sildenafil) and G4 (streptozotocin + 15 mg/kg sildenafil). The animals received sildenafil during seven days before the application of streptozotocin, maintaining the treatment for another 3 weeks. After euthanasia, hematological and biochemical analyzes were performed. The group that received the highest dose of SIL, showed a decrease in leukocytes compared to the G2 group (p <0.05). In addition, G2 presented thrombocytopenia. Therefore, sildenafil appears to decrease the number of inflammatory cells in hyperglycemic rats in a dose dependent manner.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335
10.34117/bjdv7n3-339
url https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335
identifier_str_mv 10.34117/bjdv7n3-339
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335/20883
dc.rights.driver.fl_str_mv Copyright (c) 2021 Brazilian Journal of Development
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Brazilian Journal of Development
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Development; Vol. 7 No. 3 (2021); 25872-25886
Brazilian Journal of Development; Vol. 7 Núm. 3 (2021); 25872-25886
Brazilian Journal of Development; v. 7 n. 3 (2021); 25872-25886
2525-8761
reponame:Revista Veras
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instname_str Instituto Superior de Educação Vera Cruz (VeraCruz)
instacron_str VERACRUZ
institution VERACRUZ
reponame_str Revista Veras
collection Revista Veras
repository.name.fl_str_mv Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)
repository.mail.fl_str_mv ||revistaveras@veracruz.edu.br
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dc.identifier.doi.none.fl_str_mv 10.34117/bjdv7n3-339