Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Veras |
DOI: | 10.34117/bjdv7n3-339 |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335 |
Resumo: | Diabetes mellitus is a pathology related to changes in glucose metabolism. The hormone insulin acts stimulating intracellular glucose metabolic pathways. The increase in cGMP signaling has the potential to increase insulin sensitivity in the muscle and can stimulate the secretion of this hormone by pancreatic beta cells. Sildenafil (SIL) is a potent peripheral vasodilator that acts attenuating the catabolism of cGMP thus increasing the signaling of the pathways involving the protein kinase G. The present study aimed to evaluate the effect of the sildenafil on hematological and biochemical paramethers in hyperglycemic rats. 55 male Wistar rats were separated into 4 groups: G1 (control), G2 (streptozotocin), G3 (streptozotocin + 10 mg/kg sildenafil) and G4 (streptozotocin + 15 mg/kg sildenafil). The animals received sildenafil during seven days before the application of streptozotocin, maintaining the treatment for another 3 weeks. After euthanasia, hematological and biochemical analyzes were performed. The group that received the highest dose of SIL, showed a decrease in leukocytes compared to the G2 group (p <0.05). In addition, G2 presented thrombocytopenia. Therefore, sildenafil appears to decrease the number of inflammatory cells in hyperglycemic rats in a dose dependent manner. |
id |
VERACRUZ-0_89927616c69fe362c6328ab5f74c816f |
---|---|
oai_identifier_str |
oai:ojs2.ojs.brazilianjournals.com.br:article/26335 |
network_acronym_str |
VERACRUZ-0 |
network_name_str |
Revista Veras |
spelling |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com SildenafilDiabetes MellitusStreptozotocinInflammationCyclic Guanosine MonophosphateErythrogramLeukogram.Diabetes mellitus is a pathology related to changes in glucose metabolism. The hormone insulin acts stimulating intracellular glucose metabolic pathways. The increase in cGMP signaling has the potential to increase insulin sensitivity in the muscle and can stimulate the secretion of this hormone by pancreatic beta cells. Sildenafil (SIL) is a potent peripheral vasodilator that acts attenuating the catabolism of cGMP thus increasing the signaling of the pathways involving the protein kinase G. The present study aimed to evaluate the effect of the sildenafil on hematological and biochemical paramethers in hyperglycemic rats. 55 male Wistar rats were separated into 4 groups: G1 (control), G2 (streptozotocin), G3 (streptozotocin + 10 mg/kg sildenafil) and G4 (streptozotocin + 15 mg/kg sildenafil). The animals received sildenafil during seven days before the application of streptozotocin, maintaining the treatment for another 3 weeks. After euthanasia, hematological and biochemical analyzes were performed. The group that received the highest dose of SIL, showed a decrease in leukocytes compared to the G2 group (p <0.05). In addition, G2 presented thrombocytopenia. Therefore, sildenafil appears to decrease the number of inflammatory cells in hyperglycemic rats in a dose dependent manner.Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-03-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/2633510.34117/bjdv7n3-339Brazilian Journal of Development; Vol. 7 No. 3 (2021); 25872-25886Brazilian Journal of Development; Vol. 7 Núm. 3 (2021); 25872-25886Brazilian Journal of Development; v. 7 n. 3 (2021); 25872-258862525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335/20883Copyright (c) 2021 Brazilian Journal of Developmentinfo:eu-repo/semantics/openAccessMelo, Ana Paula deDelfrate, GabrielleMroczek, TaylineJaymes, Arielen MachadoKoga, Adriana YurikoFranco, Gilson Cesar NobreClaudino, MarcelaLipinski, Leandro Cavalcante2022-03-29T12:15:33Zoai:ojs2.ojs.brazilianjournals.com.br:article/26335Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:14:15.607739Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false |
dc.title.none.fl_str_mv |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil |
title |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil |
spellingShingle |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil Melo, Ana Paula de Diabetes Mellitus Streptozotocin Inflammation Cyclic Guanosine Monophosphate Erythrogram Leukogram. Melo, Ana Paula de Diabetes Mellitus Streptozotocin Inflammation Cyclic Guanosine Monophosphate Erythrogram Leukogram. |
title_short |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil |
title_full |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil |
title_fullStr |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil |
title_full_unstemmed |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil |
title_sort |
Evaluation of Hematological and Biochemical effects of sildenafil in hyperglicemic Rats/ Avaliação Hematológica e Bioquímica de Ratos Hiperglicêmicos tratados com Sildenafil |
author |
Melo, Ana Paula de |
author_facet |
Melo, Ana Paula de Melo, Ana Paula de Delfrate, Gabrielle Mroczek, Tayline Jaymes, Arielen Machado Koga, Adriana Yuriko Franco, Gilson Cesar Nobre Claudino, Marcela Lipinski, Leandro Cavalcante Delfrate, Gabrielle Mroczek, Tayline Jaymes, Arielen Machado Koga, Adriana Yuriko Franco, Gilson Cesar Nobre Claudino, Marcela Lipinski, Leandro Cavalcante |
author_role |
author |
author2 |
Delfrate, Gabrielle Mroczek, Tayline Jaymes, Arielen Machado Koga, Adriana Yuriko Franco, Gilson Cesar Nobre Claudino, Marcela Lipinski, Leandro Cavalcante |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Melo, Ana Paula de Delfrate, Gabrielle Mroczek, Tayline Jaymes, Arielen Machado Koga, Adriana Yuriko Franco, Gilson Cesar Nobre Claudino, Marcela Lipinski, Leandro Cavalcante |
dc.subject.por.fl_str_mv |
Diabetes Mellitus Streptozotocin Inflammation Cyclic Guanosine Monophosphate Erythrogram Leukogram. |
topic |
Diabetes Mellitus Streptozotocin Inflammation Cyclic Guanosine Monophosphate Erythrogram Leukogram. |
description |
Diabetes mellitus is a pathology related to changes in glucose metabolism. The hormone insulin acts stimulating intracellular glucose metabolic pathways. The increase in cGMP signaling has the potential to increase insulin sensitivity in the muscle and can stimulate the secretion of this hormone by pancreatic beta cells. Sildenafil (SIL) is a potent peripheral vasodilator that acts attenuating the catabolism of cGMP thus increasing the signaling of the pathways involving the protein kinase G. The present study aimed to evaluate the effect of the sildenafil on hematological and biochemical paramethers in hyperglycemic rats. 55 male Wistar rats were separated into 4 groups: G1 (control), G2 (streptozotocin), G3 (streptozotocin + 10 mg/kg sildenafil) and G4 (streptozotocin + 15 mg/kg sildenafil). The animals received sildenafil during seven days before the application of streptozotocin, maintaining the treatment for another 3 weeks. After euthanasia, hematological and biochemical analyzes were performed. The group that received the highest dose of SIL, showed a decrease in leukocytes compared to the G2 group (p <0.05). In addition, G2 presented thrombocytopenia. Therefore, sildenafil appears to decrease the number of inflammatory cells in hyperglycemic rats in a dose dependent manner. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335 10.34117/bjdv7n3-339 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335 |
identifier_str_mv |
10.34117/bjdv7n3-339 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26335/20883 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Brazilian Journal of Development info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Brazilian Journal of Development |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Development; Vol. 7 No. 3 (2021); 25872-25886 Brazilian Journal of Development; Vol. 7 Núm. 3 (2021); 25872-25886 Brazilian Journal of Development; v. 7 n. 3 (2021); 25872-25886 2525-8761 reponame:Revista Veras instname:Instituto Superior de Educação Vera Cruz (VeraCruz) instacron:VERACRUZ |
instname_str |
Instituto Superior de Educação Vera Cruz (VeraCruz) |
instacron_str |
VERACRUZ |
institution |
VERACRUZ |
reponame_str |
Revista Veras |
collection |
Revista Veras |
repository.name.fl_str_mv |
Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz) |
repository.mail.fl_str_mv |
||revistaveras@veracruz.edu.br |
_version_ |
1822183743299780608 |
dc.identifier.doi.none.fl_str_mv |
10.34117/bjdv7n3-339 |