Acute aerobic session increased anti-inflammatory cytokine (IL-10) in CKD patients / A sessão aeróbica aguda aumentou a citocina anti-inflamatória (IL-10) em pacientes com CKD

• Autor(a) principal: Pinto, Walter Pereira
• Data de Publicação: 2021
• Outros Autores: Rezende, Rafael Andrade, Júnior, Armando Morales, Aquila, Luiz Phellipe Dell, Grabulosa, Caren Cristina, Elias, Rosilene Motta, Tinucci, Taís, Dalboni, Maria Aparecida
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Veras
• DOI: 10.34117/bjdv7n3-247
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/26118
• topic: Acute Aerobic exercise; Inflammation; Chronic Kidney Disease

In patients with chronic kidney disease (CKD), the presence of inflammation is a predictor of mortality. The aerobic exercise has been described to modulate the inflammatory response in general population. However, CKD patients have some limitations to performed aerobic exercise frequently. Thus, the present study evaluated the effect of an acute aerobic exercise session on markers of inflammation in non-dialytic CKD patients. MATERIALS AND METHODS: 10 stage 3 CKD patients and 10 subjects with normal kidney function performed experimental sessions of aerobic exercise on a cycle ergometer for 45 min, 50% at VO2peak. Before and after the session, blood samples were collected for the analysis of IL-6, TNF-?, IL-10, CRP, NGAL and Cystatin C.  The general linear model (GLM) test were used to evaluated the differences and interaction between group and time and Pearson's correlations were used to evaluate the association between the variables. RESULTS: Interestingly, after an aerobic exercise session, IL-10 levels increased in both group and more prominent in CKD group (p <0.0001). As expected, CKD patients were more inflamed compared to the control group and IL-6 and TNF-? had a positive correlation with Cystatin-C and NGAL, markers of renal failure (p < 0.001). CONCLUSION: In this study, an acute aerobic exercise session was able to increase IL-10 levels in CKD patients, suggesting that acute aerobic exercise may contribute to an anti-inflammatory response. However, it is necessary future studies to evaluate the impact of increased IL-10 and acute aerobic exercise on outcomes in patients with CKD.