Obtaining a Dermocosmetics from the aerial parts of Eclipta alba (L.) for the treatment of alopecia / Obtenção de um Dermocosmético das partes aéreas de Eclipta alba (L.) para o tratamento da alopecia

• Autor(a) principal: Nascimento, Flávia Sales Lopes do
• Data de Publicação: 2021
• Outros Autores: Ferreira, Magda Rhayanny Assunção, Rego Barros, Maria Luiza Carneiro Moura Gonçalves, Araújo, Evani de Lemos, Soares, Luiz Alberto Lira, Silva, Rosali Maria Ferreira, Rolim, Larissa Araújo, –Neto, Pedro José Rolim
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Veras
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/29757
• topic: Eclipta alba; Hair; Alopecia; Thin Layer Chromatography.

Eclipta alba (L.) has been studied for years to treat various diseases amongst them, the alopecia. The objective of this work was to perform the physico-chemical and phytochemical characterization of E. alba to develop a capillary product for alopecia. The physico-chemical characterization of the aerial parts of the herbal drug was performed according to the Brazilian Pharmacopoeia 6th edition, and the phytochemical analysis was based on the literature. Then the methanolic extract obtained was subjected to spray drying for subsequent incorporation into the dermocosmetic batches. Finally, the product was subjected to quality control analyzes for 15 days and the quantification of wedelolactone was also performed. The percentage of total ashes of the E. alba powder was considered high value, when compared to a published study, where the value of the non-volatile inorganic impurities of the vegetable drug was 10.54%. According to the Brazilian Pharmacopoeia, the humidity of E. alba powder is within the specified limit, which is 8 to 14%. With the granulometric distribution, it was possible to classify it as moderately thick. The pH of the methanolic extract was within the considered ideal for the cosmetic formulations, which is between 4.5 and 6.0. The Thin Layer Chromatography of the extractive solution revealed the presence of several constituents that have pharmacological activities, amongst them it was possible to evidence the presence of wedelolactone, a coumarin that provides capillary growth. Additionally, the coumarin assay was performed by spectrophotometry at 340 nm, demonstrating the linearity of the method. Therefore, E. alba has been used in a formulation that satisfy the specific care that alopecia needs and meets the expectations of the population that has been affected by hair loss.