Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils

Detalhes bibliográficos
Autor(a) principal: PINTO,MARIA E.A.
Data de Publicação: 2017
Outros Autores: ARAÚJO,STHÉFANE G., MORAIS,MARCELA I., SÁ,NÍVEA P., LIMA,CAROLINE M., ROSA,CARLOS A., SIQUEIRA,EZEQUIAS P., JOHANN,SUSANA, LIMA,LUCIANA A.R.S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401671
Resumo: ABSTRACT Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.
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spelling Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oilsantifungalantioxidantfatty acid methyl estersvegetable oilsABSTRACT Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.Academia Brasileira de Ciências2017-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401671Anais da Academia Brasileira de Ciências v.89 n.3 2017reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201720160908info:eu-repo/semantics/openAccessPINTO,MARIA E.A.ARAÚJO,STHÉFANE G.MORAIS,MARCELA I.SÁ,NÍVEA P.LIMA,CAROLINE M.ROSA,CARLOS A.SIQUEIRA,EZEQUIAS P.JOHANN,SUSANALIMA,LUCIANA A.R.S.eng2019-11-29T00:00:00Zoai:scielo:S0001-37652017000401671Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2019-11-29T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
title Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
spellingShingle Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
PINTO,MARIA E.A.
antifungal
antioxidant
fatty acid methyl esters
vegetable oils
title_short Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
title_full Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
title_fullStr Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
title_full_unstemmed Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
title_sort Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
author PINTO,MARIA E.A.
author_facet PINTO,MARIA E.A.
ARAÚJO,STHÉFANE G.
MORAIS,MARCELA I.
SÁ,NÍVEA P.
LIMA,CAROLINE M.
ROSA,CARLOS A.
SIQUEIRA,EZEQUIAS P.
JOHANN,SUSANA
LIMA,LUCIANA A.R.S.
author_role author
author2 ARAÚJO,STHÉFANE G.
MORAIS,MARCELA I.
SÁ,NÍVEA P.
LIMA,CAROLINE M.
ROSA,CARLOS A.
SIQUEIRA,EZEQUIAS P.
JOHANN,SUSANA
LIMA,LUCIANA A.R.S.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv PINTO,MARIA E.A.
ARAÚJO,STHÉFANE G.
MORAIS,MARCELA I.
SÁ,NÍVEA P.
LIMA,CAROLINE M.
ROSA,CARLOS A.
SIQUEIRA,EZEQUIAS P.
JOHANN,SUSANA
LIMA,LUCIANA A.R.S.
dc.subject.por.fl_str_mv antifungal
antioxidant
fatty acid methyl esters
vegetable oils
topic antifungal
antioxidant
fatty acid methyl esters
vegetable oils
description ABSTRACT Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401671
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401671
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201720160908
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.89 n.3 2017
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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