Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report
Main Author: | |
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Publication Date: | 2009 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Arquivos brasileiros de oftalmologia (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000200020 |
Summary: | The authors present a rare case of plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma in a 42-year-old woman. The lesion was surgically removed and analyzed. Histopathological examination with immunostaining revealed it to be positive for immunoglobulin G and Kappa chains, demonstrating monoclonality. However, no abnormality was observed on serum electrophoresis, skeletal survey and bone marrow aspiration. Therefore, the tumor was diagnosed solitary plasmacytoma of bone. The patient was treated with external beam radiotherapy and has remained disease free for 5 years and 6 months until 2007, when she presented a pathological fracture due to multiple myeloma. Extensive medical work-up to rule out multiple myeloma or other malignant lymphoproliferative conditions involving orbit or ocular adnexa is needed when the diagnosis of solitary plasmacytoma of bone is suspected because treatment and prognosis are very different. |
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Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case reportPlasmacytomaOrbital neoplasms/radiotherapyLacrimal apparatusImmunoglobulin kappa-chainsNeoplasm invasivenessMultiple myelomaTomography, x-ray computedHumanFemaleAdultCase reportsThe authors present a rare case of plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma in a 42-year-old woman. The lesion was surgically removed and analyzed. Histopathological examination with immunostaining revealed it to be positive for immunoglobulin G and Kappa chains, demonstrating monoclonality. However, no abnormality was observed on serum electrophoresis, skeletal survey and bone marrow aspiration. Therefore, the tumor was diagnosed solitary plasmacytoma of bone. The patient was treated with external beam radiotherapy and has remained disease free for 5 years and 6 months until 2007, when she presented a pathological fracture due to multiple myeloma. Extensive medical work-up to rule out multiple myeloma or other malignant lymphoproliferative conditions involving orbit or ocular adnexa is needed when the diagnosis of solitary plasmacytoma of bone is suspected because treatment and prognosis are very different.Conselho Brasileiro de Oftalmologia2009-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000200020Arquivos Brasileiros de Oftalmologia v.72 n.2 2009reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492009000200020info:eu-repo/semantics/openAccessRomero,Ivana LopesCampos,Felipe Augusto Garcez deDamasceno,Renato Wendell FerreiraVital Filho,JoséBison,Simone Haber Duellberg Von Fabereng2009-05-21T00:00:00Zoai:scielo:S0004-27492009000200020Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2009-05-21T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report |
title |
Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report |
spellingShingle |
Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report Romero,Ivana Lopes Plasmacytoma Orbital neoplasms/radiotherapy Lacrimal apparatus Immunoglobulin kappa-chains Neoplasm invasiveness Multiple myeloma Tomography, x-ray computed Human Female Adult Case reports |
title_short |
Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report |
title_full |
Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report |
title_fullStr |
Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report |
title_full_unstemmed |
Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report |
title_sort |
Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report |
author |
Romero,Ivana Lopes |
author_facet |
Romero,Ivana Lopes Campos,Felipe Augusto Garcez de Damasceno,Renato Wendell Ferreira Vital Filho,José Bison,Simone Haber Duellberg Von Faber |
author_role |
author |
author2 |
Campos,Felipe Augusto Garcez de Damasceno,Renato Wendell Ferreira Vital Filho,José Bison,Simone Haber Duellberg Von Faber |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Romero,Ivana Lopes Campos,Felipe Augusto Garcez de Damasceno,Renato Wendell Ferreira Vital Filho,José Bison,Simone Haber Duellberg Von Faber |
dc.subject.por.fl_str_mv |
Plasmacytoma Orbital neoplasms/radiotherapy Lacrimal apparatus Immunoglobulin kappa-chains Neoplasm invasiveness Multiple myeloma Tomography, x-ray computed Human Female Adult Case reports |
topic |
Plasmacytoma Orbital neoplasms/radiotherapy Lacrimal apparatus Immunoglobulin kappa-chains Neoplasm invasiveness Multiple myeloma Tomography, x-ray computed Human Female Adult Case reports |
description |
The authors present a rare case of plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma in a 42-year-old woman. The lesion was surgically removed and analyzed. Histopathological examination with immunostaining revealed it to be positive for immunoglobulin G and Kappa chains, demonstrating monoclonality. However, no abnormality was observed on serum electrophoresis, skeletal survey and bone marrow aspiration. Therefore, the tumor was diagnosed solitary plasmacytoma of bone. The patient was treated with external beam radiotherapy and has remained disease free for 5 years and 6 months until 2007, when she presented a pathological fracture due to multiple myeloma. Extensive medical work-up to rule out multiple myeloma or other malignant lymphoproliferative conditions involving orbit or ocular adnexa is needed when the diagnosis of solitary plasmacytoma of bone is suspected because treatment and prognosis are very different. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000200020 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000200020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492009000200020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.72 n.2 2009 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
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1754209025607598080 |