Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.

Detalhes bibliográficos
Autor(a) principal: Nonato, Fabiana Regina
Data de Publicação: 2009
Outros Autores: Barros, Taís Adelita de Almeida, Lucchese, Angélica Maria, Oliveira, Carlos Eduardo Cordeiro, Ribeiro-dos-Santos, Ricardo, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9015
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Nonato, Fabiana ReginaBarros, Taís Adelita de AlmeidaLucchese, Angélica MariaOliveira, Carlos Eduardo CordeiroRibeiro-dos-Santos, RicardoSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2014-12-01T16:58:24Z2014-12-01T16:58:24Z2009NONATO, F. R. et al. Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract. Journal of Ethnopharmacology, v. 125, n. 1, p. 102-107, 2009.1872-7573https://www.arca.fiocruz.br/handle/icict/9015engElsevierAntiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Estadual de Feira de Santana. Laboratório de Química de Produtos Naturais e Bioativos. Departamento de Ciências Exatas. Feira de Santana, BA, BrasilUniversidade Estadual de Feira de Santana. Laboratório de Química de Produtos Naturais e Bioativos. Departamento de Ciências Exatas. Feira de Santana, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilAim of study: Blechnum occidentale L. is a terrestrial fern that ranges from the United States to South America, and is employed in Brazilian folk medicine. In the present study we investigated the antinociceptive and antiinflammatory activities of the methanolic extract of Blechnum occidentale L. (MEB) in animal models of pain and inflammation to support its medicinal use in treatment of inflammatory and pulmonary diseases, urinary infections and liver diseases. Materials and methods: The antinociceptive activity of MEB was evaluated using the writhing, formalin, and tail flick tests. The antiinflammatory activity of MEB was evaluated in carrageenan-induced paw oedema and neutrophil migration. In order to discard possible non-specific muscle relaxant or sedative effects of MEB, mice motor performance was evaluated in the rota rod test and its toxicity evaluated over 14 days. Results: Intraperitoneal (IP) administration of MEB (0.01–100 mg/kg) produced a dose-related antinociception on acetic acid-induced writhing in mice. Oral administration of MEB, at a different range of doses (100–400 mg/kg), also produced significant antinociceptive effect on the writhing test. Furthermore, treatment with MEB (100 and 200 mg/kg IP) inhibited significantly both the early and late phases of formalin-induced hypernociception in rats. In contrast, treatment with MEB (100 and 200 mg/kg IP) did not prevent the thermal nociception in the tail flick test. The IP administration of MEB (100 and 300 mg/kg) significantly reduced the paw oedema induced by carrageenan. Moreover, systemic treatment with MEB (11–300 mg/kg) reduced the neutrophil migration in the carrageenan-induced migration to the peritoneal cavity. In the rota rod test, MEB-treated mice did not show any significant motor performance alterations with the dose of 300 mg/kg. In addition, over the study duration of 14 days, there were no deaths or toxic signs recorded in the mice given 100 or 1000 mg/kg of MEB. Conclusion: The results described here are the first report of pharmacological studies of Blechnum occidentale L. and indicate that this plant has antinociceptive and antiinflammatory activities which support its folk medicine use.BlechnumPteridophyteAntinociceptionAntiinflammatoryBiological activityBlechnumPteridophyteAntinociceptionAntiinflammatoryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALNonato F R Antinflammatory and....pdfNonato F R Antinflammatory and....pdfapplication/pdf353227https://www.arca.fiocruz.br/bitstream/icict/9015/2/Nonato%20F%20R%20Antinflammatory%20and....pdf0bac3212f8f9df561e8643035d74e8cbMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9015/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTNonato F R Antinflammatory and....pdf.txtNonato F R Antinflammatory and....pdf.txtExtracted texttext/plain35770https://www.arca.fiocruz.br/bitstream/icict/9015/4/Nonato%20F%20R%20Antinflammatory%20and....pdf.txt508809f6371562308d948d062f202adaMD54icict/90152023-03-15 14:32:56.385oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.
title Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.
spellingShingle Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.
Nonato, Fabiana Regina
Blechnum
Pteridophyte
Antinociception
Antiinflammatory
Biological activity
Blechnum
Pteridophyte
Antinociception
Antiinflammatory
title_short Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.
title_full Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.
title_fullStr Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.
title_full_unstemmed Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.
title_sort Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract.
author Nonato, Fabiana Regina
author_facet Nonato, Fabiana Regina
Barros, Taís Adelita de Almeida
Lucchese, Angélica Maria
Oliveira, Carlos Eduardo Cordeiro
Ribeiro-dos-Santos, Ricardo
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author_role author
author2 Barros, Taís Adelita de Almeida
Lucchese, Angélica Maria
Oliveira, Carlos Eduardo Cordeiro
Ribeiro-dos-Santos, Ricardo
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nonato, Fabiana Regina
Barros, Taís Adelita de Almeida
Lucchese, Angélica Maria
Oliveira, Carlos Eduardo Cordeiro
Ribeiro-dos-Santos, Ricardo
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
dc.subject.en.pt_BR.fl_str_mv Blechnum
Pteridophyte
Antinociception
Antiinflammatory
Biological activity
topic Blechnum
Pteridophyte
Antinociception
Antiinflammatory
Biological activity
Blechnum
Pteridophyte
Antinociception
Antiinflammatory
dc.subject.keyword.none.fl_str_mv Blechnum
Pteridophyte
Antinociception
Antiinflammatory
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2014-12-01T16:58:24Z
dc.date.available.fl_str_mv 2014-12-01T16:58:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv NONATO, F. R. et al. Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract. Journal of Ethnopharmacology, v. 125, n. 1, p. 102-107, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9015
dc.identifier.issn.none.fl_str_mv 1872-7573
identifier_str_mv NONATO, F. R. et al. Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract. Journal of Ethnopharmacology, v. 125, n. 1, p. 102-107, 2009.
1872-7573
url https://www.arca.fiocruz.br/handle/icict/9015
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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