Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract

Detalhes bibliográficos
Autor(a) principal: Nonato, Fabiana Regina
Data de Publicação: 2009
Outros Autores: Barros, Taís Adelita de Almeida, Lucchese, Angélica Maria, Oliveira, Carlos Eduardo Cordeiro, Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6370
Resumo: Trabalho completo: acesso restrito, p.102–107
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spelling Nonato, Fabiana ReginaBarros, Taís Adelita de AlmeidaLucchese, Angélica MariaOliveira, Carlos Eduardo CordeiroSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraVillarreal, Cristiane FloraNonato, Fabiana ReginaBarros, Taís Adelita de AlmeidaLucchese, Angélica MariaOliveira, Carlos Eduardo CordeiroSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2012-07-06T19:39:44Z20090378-8741http://www.repositorio.ufba.br/ri/handle/ri/6370v. 125, n. 1Trabalho completo: acesso restrito, p.102–107Blechnum occidentale L. is a terrestrial fern that ranges from the United States to South America, and is employed in Brazilian folk medicine. In the present study we investigated the antinociceptive and antiinflammatory activities of the methanolic extract of Blechnum occidentale L. (MEB) in animal models of pain and inflammation to support its medicinal use in treatment of inflammatory and pulmonary diseases, urinary infections and liver diseases. The antinociceptive activity of MEB was evaluated using the writhing, formalin, and tail flick tests. The antiinflammatory activity of MEB was evaluated in carrageenan-induced paw oedema and neutrophil migration. In order to discard possible non-specific muscle relaxant or sedative effects of MEB, mice motor performance was evaluated in the rota rod test and its toxicity evaluated over 14 days. Intraperitoneal (IP) administration of MEB (0.01–100 mg/kg) produced a dose-related antinociception on acetic acid-induced writhing in mice. Oral administration of MEB, at a different range of doses (100–400 mg/kg), also produced significant antinociceptive effect on the writhing test. Furthermore, treatment with MEB (100 and 200 mg/kg IP) inhibited significantly both the early and late phases of formalin-induced hypernociception in rats. In contrast, treatment with MEB (100 and 200 mg/kg IP) did not prevent the thermal nociception in the tail flick test. The IP administration of MEB (100 and 300 mg/kg) significantly reduced the paw oedema induced by carrageenan. Moreover, systemic treatment with MEB (11–300 mg/kg) reduced the neutrophil migration in the carrageenan-induced migration to the peritoneal cavity. In the rota rod test, MEB-treated mice did not show any significant motor performance alterations with the dose of 300 mg/kg. In addition, over the study duration of 14 days, there were no deaths or toxic signs recorded in the mice given 100 or 1000 mg/kg of MEB. The results described here are the first report of pharmacological studies of Blechnum occidentale L. and indicate that this plant has antinociceptive and antiinflammatory activities which support its folk medicine use.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-07-06T19:39:44Z No. of bitstreams: 1 (109)1-s2.0-S0378874109003511-main.pdf: 353227 bytes, checksum: 0bac3212f8f9df561e8643035d74e8cb (MD5)Made available in DSpace on 2012-07-06T19:39:44Z (GMT). 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dc.title.pt_BR.fl_str_mv Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
dc.title.alternative.pt_BR.fl_str_mv Journal of Ethnopharmacology
title Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
spellingShingle Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
Nonato, Fabiana Regina
Blechnum
Pteridophyte
Antinociception
Antiinflammatory
Biological activity
title_short Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
title_full Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
title_fullStr Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
title_full_unstemmed Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
title_sort Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
author Nonato, Fabiana Regina
author_facet Nonato, Fabiana Regina
Barros, Taís Adelita de Almeida
Lucchese, Angélica Maria
Oliveira, Carlos Eduardo Cordeiro
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author_role author
author2 Barros, Taís Adelita de Almeida
Lucchese, Angélica Maria
Oliveira, Carlos Eduardo Cordeiro
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nonato, Fabiana Regina
Barros, Taís Adelita de Almeida
Lucchese, Angélica Maria
Oliveira, Carlos Eduardo Cordeiro
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Nonato, Fabiana Regina
Barros, Taís Adelita de Almeida
Lucchese, Angélica Maria
Oliveira, Carlos Eduardo Cordeiro
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
dc.subject.por.fl_str_mv Blechnum
Pteridophyte
Antinociception
Antiinflammatory
Biological activity
topic Blechnum
Pteridophyte
Antinociception
Antiinflammatory
Biological activity
description Trabalho completo: acesso restrito, p.102–107
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-07-06T19:39:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6370
dc.identifier.issn.none.fl_str_mv 0378-8741
dc.identifier.number.pt_BR.fl_str_mv v. 125, n. 1
identifier_str_mv 0378-8741
v. 125, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/6370
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.jep.2009.06.005
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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