Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14734 |
Resumo: | Texto completo: acesso restrito. p. 518–524 |
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Villarreal, Cristiane FloraNonato, Fabiana ReginaNogueira, Tâmara Magalhães OliveiraBarros, Taís Adelita de AlmeidaLucchese, Angélica MariaOliveira, Carlos Eduardo CordeiroSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraVillarreal, Cristiane FloraNonato, Fabiana ReginaNogueira, Tâmara Magalhães OliveiraBarros, Taís Adelita de AlmeidaLucchese, Angélica MariaOliveira, Carlos Eduardo CordeiroSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2014-03-12T17:55:42Z20110378-8741http://repositorio.ufba.br/ri/handle/ri/14734v. 136 n. 3Texto completo: acesso restrito. p. 518–524Aim of study: Adiantum, one of the most widely distributed genera of the family Pteridaceae, is employed in folk medicine worldwide. Adiantum latifolium Lam. has been used in Latin American traditional medicine as anxiolytic, analgesic and antiinflammatory. The present study investigates the antinociceptive and antiinflammatory properties of the methanolic extract of Adiantum latifolium (MEA) in animal models of pain and inflammation to confirm its medicinal use. Material and methods: The antinociceptive and antiinflammatory activities of MEA were evaluated using the writhing, formalin, and tail-flick tests, carrageenan-induced paw edema and arachidonic acid-induced ear edema. Mice motor performance was evaluated in the rota rod test and the acute toxicity evaluated over 14 days. Results: Intraperitoneal (1–100 mg/kg) or oral (100–400 mg/kg) administration of MEA produced a dose-related inhibition of acetic acid-induced writhing in mouse. Furthermore, treatment with MEA (100 mg/kg) inhibited both the early and late phases of formalin-induced hypernociception. In contrast, MEA (100 mg/kg/IP) did not prevent the thermal nociception in the tail-flick test. In addition, MEA (100 and 200 mg/kg/IP) inhibited important events related to the inflammatory response induced by carrageenan or arachidonic acid, namely local edema and increase in tissue interleukin-1β levels. MEA (300 mg/kg/IP)-treated mice did not show any motor performance alterations. Over the study period of 14 days, there were no deaths or toxic signs recorded in the group of mice given 1000 mg/kg of MEA. Conclusion: The results demonstrate that Adiantum latifolium has antinociceptive and antiinflammatory activities, acting through the inhibition of IL-1β production.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-03-12T14:27:03Z No. of bitstreams: 1 Cristiane Flora Villarreal.pdf: 594276 bytes, checksum: b0d66da8523776a2790724667c0f6d07 (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-03-12T17:55:42Z (GMT) No. of bitstreams: 1 Cristiane Flora Villarreal.pdf: 594276 bytes, checksum: b0d66da8523776a2790724667c0f6d07 (MD5)Made available in DSpace on 2014-03-12T17:55:42Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Ethnopharmacology |
| title |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition |
| spellingShingle |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition Villarreal, Cristiane Flora Adiantum latifolium Ferns Antinociception Antiinflammatory Interleukin-1β |
| title_short |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition |
| title_full |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition |
| title_fullStr |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition |
| title_full_unstemmed |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition |
| title_sort |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition |
| author |
Villarreal, Cristiane Flora |
| author_facet |
Villarreal, Cristiane Flora Nonato, Fabiana Regina Nogueira, Tâmara Magalhães Oliveira Barros, Taís Adelita de Almeida Lucchese, Angélica Maria Oliveira, Carlos Eduardo Cordeiro Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Nonato, Fabiana Regina Nogueira, Tâmara Magalhães Oliveira Barros, Taís Adelita de Almeida Lucchese, Angélica Maria Oliveira, Carlos Eduardo Cordeiro Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Villarreal, Cristiane Flora Nonato, Fabiana Regina Nogueira, Tâmara Magalhães Oliveira Barros, Taís Adelita de Almeida Lucchese, Angélica Maria Oliveira, Carlos Eduardo Cordeiro Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora Nonato, Fabiana Regina Nogueira, Tâmara Magalhães Oliveira Barros, Taís Adelita de Almeida Lucchese, Angélica Maria Oliveira, Carlos Eduardo Cordeiro Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| dc.subject.por.fl_str_mv |
Adiantum latifolium Ferns Antinociception Antiinflammatory Interleukin-1β |
| topic |
Adiantum latifolium Ferns Antinociception Antiinflammatory Interleukin-1β |
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Texto completo: acesso restrito. p. 518–524 |
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2011 |
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2011 |
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2014-03-12T17:55:42Z |
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v. 136 n. 3 |
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