Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Claudiney Melquíades
Data de Publicação: 2010
Outros Autores: Valadares, Helder Magno Silva, Francisco, Amanda Fortes, Arantes, Jerusa Marilda, Campos, Camila França, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis, Araújo, Márcio Sobreira Silva, Arantes, Rosa Maria Esteves, Chiari, Égler, Franco, Glória Regina, Machado, Carlos Renato, Pena, Sérgio Danilo Junho, Faria, Ana Maria Caetano de, Macedo, Andrea Mara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5792
Resumo: PRONEX; FAPEMIG (WWW.fapemig.br); CNPq (www.cnpq.br) and CAPEs (www.capes.gov.br).
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spelling Rodrigues, Claudiney MelquíadesValadares, Helder Magno SilvaFrancisco, Amanda FortesArantes, Jerusa MarildaCampos, Camila FrançaCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisAraújo, Márcio Sobreira SilvaArantes, Rosa Maria EstevesChiari, ÉglerFranco, Glória ReginaMachado, Carlos RenatoPena, Sérgio Danilo JunhoFaria, Ana Maria Caetano deMacedo, Andrea Mara2012-11-12T18:12:21Z2012-11-12T18:12:21Z2010RODRIGUES, Claudiney Melquıades et al. (2010) Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection. PLoS Negl Trop Dis 4(10): e84619352727https://www.arca.fiocruz.br/handle/icict/579210.1371/journal.pntd.0000846PRONEX; FAPEMIG (WWW.fapemig.br); CNPq (www.cnpq.br) and CAPEs (www.capes.gov.br).Universidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia, Ouro Preto, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilA century after the discovery of Trypanosoma cruzi in a child living in Lassance, Minas Gerais, Brazil in 1909, many uncertainties remain with respect to factors determining the pathogenesis of Chagas disease (CD). Herein, we simultaneously investigate the contribution of both host and parasite factors during acute phase of infection in BALB/c mice infected with the JG and/or CL Brener T. cruzi strains. JG single infected mice presented reduced parasitemia and heart parasitism, no mortality, levels of pro-inflammatory mediators (TNF-a, CCL2, IL-6 and IFN-c) similar to those found among naı¨ve animals and no clinical manifestations of disease. On the other hand, CL Brener single infected mice presented higher parasitemia and heart parasitism, as well as an increased systemic release of pro-inflammatory mediators and higher mortality probably due to a toxic shock-like systemic inflammatory response. Interestingly, coinfection with JG and CL Brener strains resulted in intermediate parasitemia, heart parasitism and mortality. This was accompanied by an increase in the systemic release of IL-10 with a parallel increase in the number of MAC-3+ and CD4+ T spleen cells expressing IL-10.Therefore, the endogenous production of IL-10 elicited by coinfection seems to be crucial to counterregulate the potentially lethal effects triggered by systemic release of pro-inflammatory mediators induced by CL Brener single infection. In conclusion, our results suggest that the composition of the infecting parasite population plays a role in the host response to T. cruzi in determining the severity of the disease in experimentally infected BALB/c mice. The combination of JG and CL Brener was able to trigger both protective inflammatory immunity and regulatory immune mechanisms that attenuate damage caused by inflammation and disease severity in BALB/c mice.engCoinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL99.2010.pdf99.2010.pdfapplication/pdf2612703https://www.arca.fiocruz.br/bitstream/icict/5792/1/99.2010.pdf33c5bc5d80c9ccc9bbc88181147fa183MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5792/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXT99.2010.pdf.txt99.2010.pdf.txtExtracted texttext/plain73336https://www.arca.fiocruz.br/bitstream/icict/5792/5/99.2010.pdf.txt747d9a1a03ba4b168428ef6c7ea4e561MD55THUMBNAIL99.2010.pdf.jpg99.2010.pdf.jpgGenerated Thumbnailimage/jpeg2225https://www.arca.fiocruz.br/bitstream/icict/5792/4/99.2010.pdf.jpg63a9c429b69cd2fa4766182d76a6d81cMD54icict/57922018-04-25 13:07:21.606oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-25T16:07:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
title Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
spellingShingle Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
Rodrigues, Claudiney Melquíades
Trypanosoma cruzi
title_short Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
title_full Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
title_fullStr Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
title_full_unstemmed Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
title_sort Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
author Rodrigues, Claudiney Melquíades
author_facet Rodrigues, Claudiney Melquíades
Valadares, Helder Magno Silva
Francisco, Amanda Fortes
Arantes, Jerusa Marilda
Campos, Camila França
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Araújo, Márcio Sobreira Silva
Arantes, Rosa Maria Esteves
Chiari, Égler
Franco, Glória Regina
Machado, Carlos Renato
Pena, Sérgio Danilo Junho
Faria, Ana Maria Caetano de
Macedo, Andrea Mara
author_role author
author2 Valadares, Helder Magno Silva
Francisco, Amanda Fortes
Arantes, Jerusa Marilda
Campos, Camila França
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Araújo, Márcio Sobreira Silva
Arantes, Rosa Maria Esteves
Chiari, Égler
Franco, Glória Regina
Machado, Carlos Renato
Pena, Sérgio Danilo Junho
Faria, Ana Maria Caetano de
Macedo, Andrea Mara
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Claudiney Melquíades
Valadares, Helder Magno Silva
Francisco, Amanda Fortes
Arantes, Jerusa Marilda
Campos, Camila França
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Araújo, Márcio Sobreira Silva
Arantes, Rosa Maria Esteves
Chiari, Égler
Franco, Glória Regina
Machado, Carlos Renato
Pena, Sérgio Danilo Junho
Faria, Ana Maria Caetano de
Macedo, Andrea Mara
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
topic Trypanosoma cruzi
description PRONEX; FAPEMIG (WWW.fapemig.br); CNPq (www.cnpq.br) and CAPEs (www.capes.gov.br).
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-11-12T18:12:21Z
dc.date.available.fl_str_mv 2012-11-12T18:12:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Claudiney Melquıades et al. (2010) Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection. PLoS Negl Trop Dis 4(10): e846
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5792
dc.identifier.issn.none.fl_str_mv 19352727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0000846
identifier_str_mv RODRIGUES, Claudiney Melquıades et al. (2010) Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection. PLoS Negl Trop Dis 4(10): e846
19352727
10.1371/journal.pntd.0000846
url https://www.arca.fiocruz.br/handle/icict/5792
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
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