Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection

Paula, Hury Hellen Souza de; Ferreira, Ana Cristina Garcia; Caetano, Diogo Gama; Delatorre, Edson; Teixeira, Sylvia Lopes Maia; Coelho, Lara Esteves; João, Eduarda Grinsztejn; Andrade, Michelle Morata de; Cardoso, Sandra Wagner; Grinsztejn, Beatriz; Veloso, Valdiléa G.; Morgado, Mariza Gonçalves; Guimarães, Monick Lindenmeyer; Côrtes, Fernanda Heloise

Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection

Detalhes bibliográficos
Autor(a) principal:	Paula, Hury Hellen Souza de
Data de Publicação:	2018
Outros Autores:	Ferreira, Ana Cristina Garcia, Caetano, Diogo Gama, Delatorre, Edson, Teixeira, Sylvia Lopes Maia, Coelho, Lara Esteves, João, Eduarda Grinsztejn, Andrade, Michelle Morata de, Cardoso, Sandra Wagner, Grinsztejn, Beatriz, Veloso, Valdiléa G., Morgado, Mariza Gonçalves, Guimarães, Monick Lindenmeyer, Côrtes, Fernanda Heloise
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/30894
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.

Metadados do item

id	CRUZ_218733c6dc03e0854203630bf618286b
oai_identifier_str	oai:www.arca.fiocruz.br:icict/30894
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Paula, Hury Hellen Souza deFerreira, Ana Cristina GarciaCaetano, Diogo GamaDelatorre, EdsonTeixeira, Sylvia Lopes MaiaCoelho, Lara EstevesJoão, Eduarda GrinsztejnAndrade, Michelle Morata deCardoso, Sandra WagnerGrinsztejn, BeatrizVeloso, Valdiléa G.Morgado, Mariza GonçalvesGuimarães, Monick LindenmeyerCôrtes, Fernanda Heloise2019-01-07T15:09:00Z2019-01-07T15:09:00Z2018PAULA, Hury Hellen Souza de et al. Reduction of infammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection. Retrovirology, p. 1-11, Dec. 2018.1742-4690https://www.arca.fiocruz.br/handle/icict/3089410.1186/s12977-018-0458-61742-4690engBMCReduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Objectives: To investigate the impact of early combined antiretroviral therapy (cART) on infammation biomarkers and immune activation during acute and early chronic HIV-1 infection. Methods: We included 12 acute (AHI), 11 early chronic (EcHI), and 18 late chronic HIV-1-infected (LcHI) individuals who were treated with cART and 18 HIV-1-uninfected (HIV-neg) individuals. Plasmatic levels of infammation biomarkers, CD8+CD38+HLA-DR+ T cell frequencies, CD4 T cell counts, CD4/CD8 ratio, total HIV-1 DNA and plasmatic viral load were evaluated. Mann–Whitney test, Pearson and Spearman correlation, and linear regression models were used for statistical analyses. Results: IP-10, IL-18, and sCD163 were signifcantly elevated at pre-ART in the AHI and EcHI groups, showing a signifcant reduction after 6 months of cART in the AHI group, achieving similar levels to the HIV-neg group. For the EcHI group, the IP-10 and sCD163 levels were also signifcantly reduced on M6-ART; however, IP-10 levels remained higher than in the HIV-neg group, and no signifcant reduction of IL-18 levels was observed. The CD8+ T cell activation levels were elevated in the AHI and EcHI groups at pre-ART and showed a signifcant reduction on M6-ART, but they were similar to levels seen for HIV-neg only after 12 months of cART. At pre-ART, IP-10 levels but not IL-18 levels were positively correlated with HIV-1 viral load in the AHI group. Conclusions: Early initiation of cART in HIV infection can reduce systemic infammation, but the earlier normalization of the infammation markers was only observed when cART was initiated in the acute phase of infection. A slower dynamic of reduction was observed for CD8+ T cell activation.HIV-1 acute infectionInflammationcARTImmune activationIP-10IL-18info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/30894/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Hury_Paula_etal_INI_IOC_2018.pdfve_Hury_Paula_etal_INI_IOC_2018.pdfapplication/pdf1269439https://www.arca.fiocruz.br/bitstream/icict/30894/2/ve_Hury_Paula_etal_INI_IOC_2018.pdf97ffc949290f126bfa437eed77516146MD52TEXTve_Hury_Paula_etal_INI_IOC_2018.pdf.txtve_Hury_Paula_etal_INI_IOC_2018.pdf.txtExtracted texttext/plain53652https://www.arca.fiocruz.br/bitstream/icict/30894/3/ve_Hury_Paula_etal_INI_IOC_2018.pdf.txt1ba4c1b87c58c543c231417762095979MD53icict/308942023-03-30 22:12:31.178oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-31T01:12:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection
title	Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection
spellingShingle	Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection Paula, Hury Hellen Souza de HIV-1 acute infection Inflammation cART Immune activation IP-10 IL-18
title_short	Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection
title_full	Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection
title_fullStr	Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection
title_full_unstemmed	Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection
title_sort	Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection
author	Paula, Hury Hellen Souza de
author_facet	Paula, Hury Hellen Souza de Ferreira, Ana Cristina Garcia Caetano, Diogo Gama Delatorre, Edson Teixeira, Sylvia Lopes Maia Coelho, Lara Esteves João, Eduarda Grinsztejn Andrade, Michelle Morata de Cardoso, Sandra Wagner Grinsztejn, Beatriz Veloso, Valdiléa G. Morgado, Mariza Gonçalves Guimarães, Monick Lindenmeyer Côrtes, Fernanda Heloise
author_role	author
author2	Ferreira, Ana Cristina Garcia Caetano, Diogo Gama Delatorre, Edson Teixeira, Sylvia Lopes Maia Coelho, Lara Esteves João, Eduarda Grinsztejn Andrade, Michelle Morata de Cardoso, Sandra Wagner Grinsztejn, Beatriz Veloso, Valdiléa G. Morgado, Mariza Gonçalves Guimarães, Monick Lindenmeyer Côrtes, Fernanda Heloise
author2_role	author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Paula, Hury Hellen Souza de Ferreira, Ana Cristina Garcia Caetano, Diogo Gama Delatorre, Edson Teixeira, Sylvia Lopes Maia Coelho, Lara Esteves João, Eduarda Grinsztejn Andrade, Michelle Morata de Cardoso, Sandra Wagner Grinsztejn, Beatriz Veloso, Valdiléa G. Morgado, Mariza Gonçalves Guimarães, Monick Lindenmeyer Côrtes, Fernanda Heloise
dc.subject.en.pt_BR.fl_str_mv	HIV-1 acute infection Inflammation cART Immune activation IP-10 IL-18
topic	HIV-1 acute infection Inflammation cART Immune activation IP-10 IL-18
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
publishDate	2018
dc.date.issued.fl_str_mv	2018
dc.date.accessioned.fl_str_mv	2019-01-07T15:09:00Z
dc.date.available.fl_str_mv	2019-01-07T15:09:00Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	PAULA, Hury Hellen Souza de et al. Reduction of infammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection. Retrovirology, p. 1-11, Dec. 2018.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/30894
dc.identifier.issn.none.fl_str_mv	1742-4690
dc.identifier.doi.pt_BR.fl_str_mv	10.1186/s12977-018-0458-6
dc.identifier.eissn.none.fl_str_mv	1742-4690
identifier_str_mv	PAULA, Hury Hellen Souza de et al. Reduction of infammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection. Retrovirology, p. 1-11, Dec. 2018. 1742-4690 10.1186/s12977-018-0458-6
url	https://www.arca.fiocruz.br/handle/icict/30894
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BMC
publisher.none.fl_str_mv	BMC
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/30894/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/30894/2/ve_Hury_Paula_etal_INI_IOC_2018.pdf https://www.arca.fiocruz.br/bitstream/icict/30894/3/ve_Hury_Paula_etal_INI_IOC_2018.pdf.txt
bitstream.checksum.fl_str_mv	79178e5f2a0eb066867a274556814938 97ffc949290f126bfa437eed77516146 1ba4c1b87c58c543c231417762095979
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1798324633739460608

Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV‑1 infection

Registros relacionados