Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain

Detalhes bibliográficos
Autor(a) principal: Souza, Mariana C.
Data de Publicação: 2015
Outros Autores: Pádua, Tatiana A., Henriques, Maria G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59629
Resumo: Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil.
id CRUZ_cc3ff3ed575e848e1af4b8cd4e076bbf
oai_identifier_str oai:www.arca.fiocruz.br:icict/59629
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Souza, Mariana C.Pádua, Tatiana A.Henriques, Maria G.2023-07-18T03:30:07Z2023-07-18T03:30:07Z2015SOUZA, Mariana C.; PÁDUA, Tatiana A.; HENRIQUES, Maria G. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation, v. 2015, p. 1-11, 2015.0962-9351https://www.arca.fiocruz.br/handle/icict/5962910.1155/2015/1689371466-1861engHindawi PublishingAnimalsBlood-Brain BarrierBrainEndotheliumHumansLeukocytesMalariaSevere MalariaEndothelial-LeukocyteBrainPlasmodium-falciparumEndothelial-Leukocyte Interaction in Severe Malaria: Beyond the Braininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil.Malaria is the most important parasitic disease worldwide, accounting for 1 million deaths each year. Severe malaria is a systemic illness characterized by dysfunction of brain tissue and of one or more peripheral organs as lungs and kidney. The most severe and most studied form of malaria is associated with cerebral complications due to capillary congestion and the adhesion of infected erythrocytes, platelets, and leukocytes to brain vasculature. Thus, leukocyte rolling and adhesion in the brain vascular bed during severe malaria is singular and distinct from other models of inflammation. The leukocyte/endothelium interaction and neutrophil accumulation are also observed in the lungs. However, lung interactions differ from brain interactions, likely due to differences in the blood-brain barrier and blood-air barrier tight junction composition of the brain and lung endothelium. Here, we review the importance of endothelial dysfunction and the mechanism of leukocyte/endothelium interaction during severe malaria. Furthermore, we hypothesize a possible use of adjunctive therapies to antimalarial drugs that target the interaction between the leukocytes and the endothelium.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59629/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINAL10.1155_2015_168937.pdfapplication/pdf5718155https://www.arca.fiocruz.br/bitstream/icict/59629/2/10.1155_2015_168937.pdfb9b1b6243a0c64bf1d139cbf3695ab71MD52icict/596292023-07-18 22:04:46.276oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-19T01:04:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
spellingShingle Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
Souza, Mariana C.
Animals
Blood-Brain Barrier
Brain
Endothelium
Humans
Leukocytes
Malaria
Severe Malaria
Endothelial-Leukocyte
Brain
Plasmodium-falciparum
title_short Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_full Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_fullStr Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_full_unstemmed Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_sort Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
author Souza, Mariana C.
author_facet Souza, Mariana C.
Pádua, Tatiana A.
Henriques, Maria G.
author_role author
author2 Pádua, Tatiana A.
Henriques, Maria G.
author2_role author
author
dc.contributor.author.fl_str_mv Souza, Mariana C.
Pádua, Tatiana A.
Henriques, Maria G.
dc.subject.mesh.en_US.fl_str_mv Animals
Blood-Brain Barrier
Brain
Endothelium
Humans
Leukocytes
Malaria
topic Animals
Blood-Brain Barrier
Brain
Endothelium
Humans
Leukocytes
Malaria
Severe Malaria
Endothelial-Leukocyte
Brain
Plasmodium-falciparum
dc.subject.en.en_US.fl_str_mv Severe Malaria
Endothelial-Leukocyte
Brain
Plasmodium-falciparum
description Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2023-07-18T03:30:07Z
dc.date.available.fl_str_mv 2023-07-18T03:30:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Mariana C.; PÁDUA, Tatiana A.; HENRIQUES, Maria G. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation, v. 2015, p. 1-11, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59629
dc.identifier.issn.en_US.fl_str_mv 0962-9351
dc.identifier.doi.none.fl_str_mv 10.1155/2015/168937
dc.identifier.eissn.none.fl_str_mv 1466-1861
identifier_str_mv SOUZA, Mariana C.; PÁDUA, Tatiana A.; HENRIQUES, Maria G. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation, v. 2015, p. 1-11, 2015.
0962-9351
10.1155/2015/168937
1466-1861
url https://www.arca.fiocruz.br/handle/icict/59629
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing
publisher.none.fl_str_mv Hindawi Publishing
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59629/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59629/2/10.1155_2015_168937.pdf
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
b9b1b6243a0c64bf1d139cbf3695ab71
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324682770874368

Registros relacionados